Involvement of dopamine D2 receptors in apomorphine-induced facilitation of forebrain serotonin output

European Journal of Pharmacology

Volumn 351, Issue 3, 1998, Pages 291-298

  Mendlin, Anna ^a   Martín, Francisco J ^a   Jacobs, Barry L ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT(1A) autoreceptor; Dopamine; Dopamine D2 receptor; Microdialysis; Stereotypy

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; APOMORPHINE; AUTORECEPTOR; DOPAMINE; DOPAMINE 2 RECEPTOR; FLUOXETINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RACLOPRIDE; SEROTONIN; SEROTONIN 1A RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; FOREBRAIN; HIPPOCAMPUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; STEREOTYPY; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; AROUSAL; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOMORPHINE; AROUSAL; CORPUS STRIATUM; DOPAMINE AGONISTS; HIPPOCAMPUS; MALE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN; STEREOTYPED BEHAVIOR;

EID: 0031595102     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00321-5     Document Type: Article

References (40)

1. Abi-Dargham, A., Laruelle, M., Aghajanian, G.K., Charney, D., Krystal, J., 1997. The role of serotonin in the pathophysiology and treatment of schizophrenia. J. Neuropsychol. Clin. Neurosci. 9, 1-17.
2. Adell, A., Artigas, F., 1997. In vivo characterization of serotonin release in the median raphe nucleus. Soc. Neurosci. Abstr. 23, 1228.
3. 1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY-100635, has partial agonist properties. Eur. J. Pharmacol. 304, 15-21.
4. Balfour, D.J.K., Iyaniwura, T.T., 1985. An investigation of amphetamine-induced release of 5-HT from rat hippocampal slices. Eur. J. Pharmacol. 109, 395-399.
5. Baumann, P., Waldmeier, P., 1981. Further evidence for negative feedback control of serotonin release in the central nervous system. Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 36-43.
6. Benloucif, S., Galloway, M.P., 1991. Facilitation of dopamine release in vivo by serotonin agonists: studies with microdialysis. Eur. J. Pharmacol. 200, 1-8.
7. 125I]-iodosulpride. Neuroscience 20, 117-155.
8. 2 dopamine receptor classification and its functional implications. Synapse 1, 347-388.
9. Costall, B., Naylor, R., Olley, J., 1972. The substantia nigra and stereotyped behavior. Eur. J. Pharmacol. 18, 95-106.
10. 2 receptor-mediated regulation of serotonin extracellular concentration in the dorsal raphe nucleus of freely moving rats. J. Neurochem. 61, 772-775.
11. Ferré, S., Cortés, R., Artigas, F., 1994. Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats. J. Neurosci. 14, 4839-4846.
12. 3H] 5-hydroxytryptamine. Br. J. Pharmacol. 88, 677-684.
13. Fornal, C.A., Metzler, C.W., Martín, F.J., Jacobs, B.L., 1996. Effects of apomorphine on the single-unit activity of serotonergic dorsal raphe neurons in behaving cats. Soc. Neurosci. Abstr. 22, 841.
14. Geffard, M., Tuffet, S., Mons, N., Chagnaud, J., 1987. Simultaneous detection of indoleamines and dopamine in rat dorsal nuclei using specific antibodies. Histochemistry 88, 61-64.
15. Grabowska, M., Antkiewicz, L., Maj, J., Michaluk, J., 1973. Apomorphine and central serotonin neurons. Pol. J. Pharmacol. 25, 29-39.
16. Hernandez, L., Lee, F., Hoebel, B.G., 1987. Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: increase in extracellular dopamine and serotonin. Brain Res. Bull. 19, 623-628.
17. Jackson, D., Westlind-Danielsson, A., 1994. Dopamine receptors: molecular biology, biochemistry, and behavioral aspects. Pharmacol. Ther. 64, 291-369.
18. Jacobs, B.L., Azmitia, E.C., 1992. Structure and function of the brain serotonin system. Physiol. Rev. 72, 165-229.
19. Jacobs, B.L, Fornal, C.A., 1997. Physiology and pharmacology of brain serotonergic neurons. In: Baumgarten, H.G., Gothert, M. (Eds.), Serotonergic Neurons and 5-HT Receptors in the CNS. Springer, Berlin, pp. 91-116.
20. Kalen, P., Skagerberg, G., Lindvall, O., 1988. Projections from the ventral tegmental area and mesencephalic raphe to the dorsal raphe nucleus in the rat. Exp. Brain Res. 73, 69-77.
21. Kalen, P., Rosegren, E., Lindvall, O., Bjorklund, A., 1989. Hippocampal noradrenaline and serotonin release over 24 h as measured by dialysis technique in freely moving rats: correlation to behavioral activity state, effect of handling and tail-pinch. Eur. J. Neurosci. 1, 181-187.
22. 3H] dopamine is taken up and released from nondopaminergic nerve terminals in the rat substantia nigra in vitro. J. Neurochem. 45, 137-144.
23. Lee, G.H.Y., 1987. Additive effects of apomorphine and clonidine on serotonin neurons in the dorsal raphe. Life Sci. 40, 635-642.
24. Lee, E.H.Y., Geyer, M.A., 1984. Dopamine autoreceptor mediation of the effects of apomorphine on serotonin neurons. Pharmacol. Biochem. Behav. 21, 301-311.
25. Le Moal, M., Simon, H., 1991. Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol. Rev. 7, 155-234.
26. Li, M.Y., Yan, Q.S., Coffey, L.L., Reith, M.E.A., 1996a. Extracellular dopamine, norepinephrine, and serotonin in the nucleus accumbens of freely moving rats during intracerebral dialysis with cocaine and other monoamine uptake blockers. J. Neurochem. 66, 559-568.
27. Li, X., Perry, K., Fuller, R., 1996b. On the in vivo modulation of neostriatal dopamine release by fluoxetine and 5-hydroxy-L-tryptophan in conscious rats. J. Pharm. Pharmacol. 48, 825-828.
28. Mann, J.J., Kapur, S., 1995. A dopaminergic hypothesis of major depression. Clin. Neuropharmacol. 18, S57-S65, Suppl. 1.
29. 2 receptor binding in the rat brain and pituitary: an in situ hybridization-receptor autoradiographic analysis. J. Neurosci. 10, 2587-2600.
30. 2 receptors in the dorsal raphe nucleus increases firing rate and 5-HT release in the rat brain. Soc. Neurosci. Abstr. 232, 1228.
31. Matsumoto, M., Yoshioka, M., Togashi, H., Ikeda, T., Saito, H., 1996. Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: in vivo microdialysis study. Naunyn-Schmiedeberg's Arch. Pharmacol. 353, 621-629.
32. Meltzer, H.Y., Nash, J.F., 1991. Effects of antipsychotic drugs on serotonin receptors. Pharmacol. Rev. 43, 587-604.
33. Mendlin, A., Martín, F.J., Rueter, L.E., Jacobs, B.L., 1996. Neuronal release of serotonin in the cerebellum of behaving rats: an in vivo microdialysis study. J. Neurochem. 67, 617-622.
34. Paxinos, G., Watson, G., 1986. The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
35. Petty, F., Kramer, G., Moeller, M., 1994. Does learned helplessness induction by haloperidol involve serotonin mediation. Pharmacol. Biochem. Behav. 48, 671-676.
36. Peyron, C., Luppi, P.H., Fort, P., Rampon, C., Jouvet, M., 1996. Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus. J. Comp. Neurol. 364, 402-413.
37. Portas, C.M., Bjorvatn, B., Fagerland, S., Gronli, J., Mundal, V., Sorensen, E., Ursin, R., 1998. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleepwake cycle in the freely moving rat. Neuroscience, in press.
38. Rueter, L.E., Jacobs, B.L., 1996. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Res. 482, 261-270.
39. Sivam, S.P., 1995. Dopaminergic modulation of serotonin metabolism in rat striatum: a study with dopamine uptake inhibitor GBR-12909. Life Sci. 26, 467-472.
40. Willner, P., 1995. Dopaminergic mechanisms in depression and mania. In: Bloom, F.E., Kupfer, D.J. (Eds.), Psychopharmacology: The Fourth Generation of Progress. Raven Press, New York, pp. 921-931.