Inhibition of protein phosphatase 1 decreases PTH secretion from isolated dispersed parathyroid cells

Molecular and Cellular Endocrinology

Volumn 154, Issue 1-2, 1999, Pages 171-177

  Matovcik, Lisa M ^a,b   Rhee, Steven S ^a   Schaefer, Jean F ^a   Da Cruz E Silva, Edgar F ^c   Kinder, Barbara K ^a  

^a Surgical Service   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Calcium; Exocytosis; Parathyroid; Protein phosphatase; Secretion; Streptolysin O

Indexed keywords

OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; STREPTOLYSIN O;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; EXOCYTOSIS; NONHUMAN; PARATHYROID CELL; PARATHYROID FUNCTION; PARATHYROID HORMONE RELEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SECRETORY GRANULE;

ANIMALS; CALCIUM; CATTLE; CELL MEMBRANE PERMEABILITY; HUMANS; OKADAIC ACID; PARATHYROID GLANDS; PARATHYROID HORMONE; PHOSPHOPROTEIN PHOSPHATASE; STREPTOLYSINS; SUBCELLULAR FRACTIONS;

EID: 0032768906     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(98)00224-X     Document Type: Article

References (34)

1. Abdul-Ghani M., Kravitz E.A., Meiri H., Rahaminoff R. Protein phosphatase inhibitor okadaic acid enhances transmitter release at neuromuscular junctions. Proc. Natl. Acad. Sci USA. 88:1991;1803-1807.
2. Ahnert-Hilger G., Mach W., Föhr K.J., Gratzl M. Poration by α-toxin and streptolysin-O: an approach to analyze intracellular processes. Rev. Physiol. Biochem. Pharmacol. 107:1989;147-223.
3. Ämmälä C., Eliasson L., Bokvist K. et al. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β-cells. Proc. Natl. Acad. Sci. USA. 91:1994;4343-4347.
4. Bialojan C., Takai A. Inhibitory effect of a marine sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. Biochem. J. 256:1988;283-290.
5. Brown E.M. Four parameter model of the sigmoidal relationship between PTH release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J. Clin. Endocrinol. Metab. 56:1983;572-581.
6. 2+ and other ions as extracellular (first) messengers. Physiol. Rev. 71:1991;371-411.
7. Bugnon O., Ofori S., Schorderet M. Okadaic acid modulates exocytotic and transporter-dependent release of dopamine in bovine retina in vitro. Naunyn Schmiedebergs Arch. Pharmacol. 351:1995;53-59.
8. Chattopadhay N., Mithal A., Brown E.M. The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocr. Rev. 17:1996;289-307.
9. Cohen P., Holmes C.F.B., Tsukitani Y. Okadaic acid: a new probe for the study of cellular regulation. Trends Biochem. Sci. 15:1990;98-102.
10. da Cruz e Silva E.F., da Cruz e Silva O.A., Zaia C.T., Greengard P. Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein. Mol. Med. 1:1995;535-541.
11. da Cruz e Silva E.F., Fox C.A., Ouimet C.C., Gustafson E., Watson S.J., Greengard P. Differential expression of protein phosphatase 1 isoforms in mammalian brain. J. Neurosci. 15:1995;3375-3389.
12. Gershoni J.M., Palade G.E. Protein blotting: principles and applications. Anal. Biochem. 131:1983;1-15.
13. Gutierrez L.M., Quintaner J.L., Rueda J., Viniegra S., Reig J.A. The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells. Eur. J. Cell Biol. 68:1995;88-95.
14. Hamm-Alvarez S.F., Wei X., Berndt N., Runnegar M. Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am. J. Physiol. 271:1996;C929-C943.
15. Ishihara H., Martin B.L., Brautigan D.L. et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Comm. 159:1989;871-877.
16. Kobayashi M., Ozawa T. Phosphoprotein phosphatase associated with rat liver plasma membrane. Properties of phosphorylase phosphatase and phosphohistone phosphatase. J. Biochem. 89:1981;731-740.
17. Kowluru A., Seavey S.E., Rabaglia M.E., Nesher R., Metz S.A. Carboxymethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion. Endocrinology. 137:1996;2315-2323.
18. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:1970;680-685.
19. +-ATPase. Am. J. Physiol. 269:1995;673-680.
20. Magnusson A., Haldorsson H., Thorgeirsson G., Kjeld M. Endothelin secretion is regulated by cyclic AMP and phosphatase 2A in endothelial cells. J. Cell. Physiol. 161:1994;429-434.
21. r 32,000) is a membrane protein in the bovine parathyroid. FEBS Lett. 364:1995;67-74.
22. Matovcik L.M., Rhee S.S., Schaefer J.F., Kinder B.K. Reconstitution of calcium regulated parathyroid hormone secretion from streptolysin-O permeabilized parathyroid cells by GTPγS. Endocrinology. 138:1997;1170-1179.
23. McFerran B.W., Guild S.B. The effects of calyculin A upon calcium-, guanine nucleotides and phorbol 12-myristate 13-acetate-stimulated ACTH secretion from AtT-20 cells. Br. J. Pharmacol. 114:1995;1571-1576.
24. Myer-Alber A., Hocker M., Fetz I. et al. Differential inhibitory effects of serine/threonine phosphatase inhibitors and a calmodulin antagonist on phosphoinositol/calcium- and cyclic adenosine monophosphate-mediated pancreatic amylase secretion. Scand. J. Gastroenterol. 30:1995;384-391.
25. Ogawa S., Katsuragi T., Matsuo K., Furukawa T. Inhibitory effect of okadaic acid in noradrenaline exocytosis from guinea-pig vas deferens. Neurosci. Lett. 178:1994;144-146.
26. Peterson G.L. Determination of total protein. Methods Enzymol. 91:1983;95-119.
27. Ratcliff H., Jones P.M. Effects of okadaic acid on insulin secretion from rat islet of Langerhans. Biochim. Biophys. Acta. 1175:1993;188-193.
28. Shenolikar S. Protein serine/threonine phosphatases - new avenues for cell regulation. Annu. Rev. Cell Biol. 10:1994;55-86.
29. Shenolikar S., Nairn A.C. Protein phosphatases: recent progress. Adv. Second Messenger Phosphoprot. Res. 23:1991;1-121.
30. Shoback D., Chen T.-H., Pratt S., Lattyak B. Thapsigargin stimulates intracellular calcium mobilization and inhibits parathyroid hormone release. J. Bone Miner. Res. 10:1995;743-750.
31. Shyjan A.W., Levenson R. Antisera for the αa1, α2, α3, and β subunits of the Na,K-ATPase: differential expression of α and β subunits in rat tissue membranes. Biochemistry. 28:1989;4531-4535.
32. Sjöholm Å., Honkanen R.E., Berggren P.-O. Inhibition of serine/threonine protein phosphatases by secretagogues in insulin-secreting cells. Endocrinol. 136:1995;3391-3397.
33. Sun F., Ritchie K., Hassager C., Maercklein P., Fitzpatrick L.A. Heterogeneous reponse to calcium by individual parathyroid cells. J. Clin. Invest. 91:1993;595-601.
34. Wagner A.C.C., Wishart M.J., Yule D.I., Williams J.A. Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling. Am. J. Physiol. 263:1992;C1172-C1180.