Cocaine metabolite kinetics in the newborn

Journal of Analytical Toxicology

Volumn 23, Issue 1, 1999, Pages 24-28

  Dempsey, Delia ^b   Jacob III, Peyton ^c   Partridge, J Colin ^c   Jones, Reese T ^c   Panganiban, Kristina ^c   Rowbotham, Michael C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO GENERAL HOSPITAL   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; COCAINE DERIVATIVE;

ARTICLE; CLINICAL ARTICLE; DRUG ABUSE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NEWBORN; PRENATAL DRUG EXPOSURE; URINALYSIS;

EID: 0032768716     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/23.1.24     Document Type: Article

References (17)

1. W.A. Vega, B. Kolody, J. Hwang, and A. Noble. Prevalence and magnitude of perinatal substance exposures in California. N. Engl. J. Med. 329: 850-854 (1993).
2. E.V. Pindel, N.Y. Kedishvili, T.L. Abraham, M.R. Brzezinski, J. Zhang, R.A. Dean, and W.F. Bosron. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. J. Biol. Chem. 272: 14769-14775 (1997).
3. D.S. Isenschmid, B.S. Levine, and Y.H. Caplan. A comprehensive study of the stability of cocaine and its metabolites. J. Anal. Toxicol. 13: 250-256 (1989).
4. T. Satoh. In Reviews in Biochemical Toxicology, E. Hodgson, J.R. Bend, and R.M. Philpot, Eds. Elsevier Publishing, New York, NY, 1987, pp 155-181.
5. M. Hosokawa, T. Endo, M. Fujisawa, S. Hara, N. Iwata, Y. Sato, and T. Satoh. Interindividual variation in carboxylesterase levels in human liver microsomes. Drug Metab. Dispos. 23: 1022-1027 (1995).
6. J.D. Osterloh and B.L. Lee. Urine drug screening in mothers and infants. Am. J. Dis. Child. 143: 791-793 (1989).
7. T. Inaba. Cocaine: pharmacokinetics and biotransformation in man. Can. J. Physiol. Pharmacol. 67: 1154-1157 (1989).
8. J. Ambre. The urinary excretion of cocaine and metabolites in humans: a kinetic analysis of published data. J. Anal. Toxicol. 9: 241-245 (1985).
9. N.L. Benowitz. Clinical pharmacology and toxicology of cocaine. Pharmacol. Toxicol. 72: 3-12 (1993).
10. R.E. Kauffman and G.L. Kearns. Pharmacokinetic studies in paediatric patients. Clinical and ethical considerations. Clin. Pharmacokinet. 23: 10-29 (1992).
11. P. Jacob, III, B.A. Elias-Baker, R.T. Jones, and N.L. Benowitz. Determination of benzoylecgonine and cocaine in biologic fluids by automated gas chromatography. J. Chromatogr. 417: 277-286 (1987).
12. BMPD Statistical Software. UC Press, Berkeley, CA, 1992.
13. NONMEM Users Guide. NONMEM Project Group, University of California at San Francisco, San Francisco, CA, 1992.
14. D.A. Dempsey, J.C. Partridge, R.T. Jones, and M.C. Rowbotham. Cocaine, nicotine, caffeine, and metabolite plasma concentrations in neonates. J. Anal. Toxicol. 22: 220-224 (1998).
15. M. Van de Bor, F.J. Walther, and M.E. Sims. Increased cerebral blood flow velocity in infants of mothers who abuse cocaine. Pediatrics 85: 733-736 (1990).
16. M. Van de Bor, F.J. Walther, and M. Ebrahimi. Decreased cardiac output in infants of mothers who abused cocaine. Pediatrics 85: 30-32 (1990).
17. I.C. Radde. In Pediatric Pharmacology and Therapeutics, I.C. Radde and S.M. MacLeod, Eds. Mosby Press, Boston, MA, 1993, pp 87-110.