Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir

Journal of Clinical Virology

Volumn 13, Issue 3, 1999, Pages 141-148

  Abraham, Bruno ^a   Lastere, Stephane ^a   Reynes, Jacques ^a   Bibollet Ruche, Frederic ^b   Vidal, Nicole ^b   Segondy, Michel ^a  

^a MONTPELLIER UNIVERSITY HOSPITAL   (France)

^b INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

Cytomegalovirus; Phenotypic resistance; UL97 phosphotransferase gene

Indexed keywords

EARLY ANTIGEN; GANCICLOVIR; PHOSPHOTRANSFERASE; RESTRICTION ENDONUCLEASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CYTOMEGALOVIRUS INFECTION; GENE MUTATION; HUMAN; HUMAN CYTOMEGALOVIRUS; PRIORITY JOURNAL; RETINITIS;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG RESISTANCE, MICROBIAL; GANCICLOVIR; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR);

EID: 0032768351     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(99)00031-1     Document Type: Article

References (27)

1. Baldanti F., Silini E., Sarasini A. et al. A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate. J Virol. 69:1995;796-800.
2. Baldanti F., Underwood M.R., Talarico C.L. et al. The Cys607 → Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients. Antimicrob Agents Chemother. 42:1998;444-446.
3. Bowen E.F., Emery V.C., Wilson P. et al. Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis. AIDS. 12:1998;605-611.
4. Chou S., Erice A., Colin Jordan M. et al. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance. J Infect Dis. 171:1995;576-583.
5. Chou S., Guentzel S., Michels K.R., Miner R.C., Drew W.L. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates. J Infect Dis. 172:1995;239-242.
6. Drew W.L. Cytomegalovirus infection in patients with AIDS. Clin Infect Dis. 14:1992;608-615.
7. Drew W.L., Miner R.C., Busch D.F. et al. Prevalence of resistance in patients receiving ganciclovir for serious cytomegalovirus infection. J Infect Dis. 163:1990;716-719.
8. Drew W.L., Ives D., Lalezari J.P. et al. Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. New Engl J Med. 333:1995;615-620.
9. Erice A., Gil-Roda C., Perez J.L. et al. Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients. J Infect Dis. 175:1997;1087-1092.
10. Erice A., Borrel N., Li W., Miller W.J., Balfour H.H. Jr. Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus (CMV) isolates from bone marrow recipients with CMV disease after antiviral prophylaxis. J Infect Dis. 178:1998;531-534.
11. Gallant J.E., Moore R.D., Richman D.D., Keruly J., Chaisson R.E. Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. J Infect Dis. 66:1992;1223-1227.
12. Gerna G., Baldanti F., Zavattoni M., Sarasini A., Percivalle E., Revello M.G. Monitoring of ganciclovir sensitivity of multiple human cytomegalovirus strains coinfecting blood of an AIDS patient by an immediate-early antigen plaque assay. Antiviral Res. 19:1992;333-345.
13. Gilbert C., Handfield J., Toma E., Lalonde R., Bergeron M.G., Boivin G. Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients. AIDS. 12:1998;125-129.
14. Hanson M.N., Preheim L.C., Chou S., Talarico C.L., Biron K.K.and, Erice A. Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir. Antimicrob Agents Chemother. 39:1995;1204-1205.
15. Hodge W.G., Lalonde R.G., Sampalis J., Deschênes J. Once-weekly intraocular injections of ganciclovir for maintenance therapy of cytomegalovirus retinitis: clinical and ocular outcome. J Infect Dis. 174:1996;393-396.
16. Jabs D.A., Enger C., Dunn J.P., Forman M. Cytomegalovirus retinitis and viral resistance: ganciclovir resistance. J Infect Dis. 177:1998;770-773.
17. Liu W., Kupperman B.D., Martin D.F., Wolitz R.A., Margolis T.P. Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis. J Infect Dis. 177:1998;1176-1181.
18. Lurain N.S., Spafford L.E., Thompson K.D. Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir. J Virol. 68:1994;4427-4431.
19. Martin D.F., Parks D.J., Mellow S.D. et al. Treatment of cytomegalovirus retinitis with an intraocular sustained release ganciclovir implant. Arch Ophtalmol. 112:1994;1531-1539.
20. Matthews T., Boehme R. Antiviral activity and mechanism of action of ganciclovir. Rev Infect Dis. 10(Suppl 3):1988;S490-S494.
21. Mazeron M.C., Jahn G., Plachter B. Monoclonal antibody E-13 (McAb810) to human cytomegalovirus recognizes an antigen encoded by exon 2 of the major immediate-early gene. J Gen Virol. 73:1992;2699-2703.
22. Reynes J., Montès B., Atoui N., Segondy M. Significance of cytomegalovirus (CMV)-pp65 antigenemia in the diagnosis of CMV disease in human immunodeficiency virus-infected patients. J Med Virol. 49:1996;195-198.
23. Smith I.L., Cherrington J.M., Jiles R.E., Fuller M.D., Freeman W.R., Spector S.A. High-level resistance of cytomegalovirus to ganciclovir is associated with alterations in both the UL97 and DNA polymerase genes. J Infect Dis. 176:1997;69-77.
24. Spector S.A., Weingeist T., Pollard R.B. et al. A randomized, controlled study of intravenous ganciclovir therapy for cytomegalovirus peripheral retinitis in patients with AIDS. J Infect Dis. 168:1993;557-563.
25. Sullivan V., Talarico C.L., Stanat S.C., Davis M., Coen D.M., Biron K.K. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells. Nature. 358:1992;162-164.
26. Wolf D.G., Lee D.J., Spector S.A. Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease. Antimicrob Agents Chemother. 39:1995;2552-2554.
27. Wolf D.G., Yaniv I., Honigman A., Kassis I., Schonfeld T., Ashkenazi S. Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency. J Infect Dis. 178:1998;535-538.