Semiquantitative and qualitative assessment of hepatic iron in patients with chronic viral hepatitis: Relation with grading, staging and haemochromatosis mutations

Italian Journal of Gastroenterology and Hepatology

Volumn 31, Issue 5, 1999, Pages 395-400

  Vergani, A ^a   Bovo, G ^a   Trombini, P ^a   Caronni, N ^a   Arosio, C ^a   Malosio, I ^a   Fossati, L ^a   Roffi, L ^a   Piperno, A ^a  

^a SAN GERARDO HOSPITAL   (Italy)

Author keywords

Chronic hepatitis; Hepatic iron distribution; HFE

Indexed keywords

IRON;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; HUMAN TISSUE; IRON OVERLOAD; LIVER CELL; LIVER HILUS; LIVER LEVEL; LIVER SINUSOID; MALE; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; TISSUE DISTRIBUTION;

ADULT; AGED; BIOPSY; FEMALE; GENES, MHC CLASS I; HEMOCHROMATOSIS; HEPATITIS B, CHRONIC; HEPATITIS C, CHRONIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IRON; IRON OVERLOAD; LIVER; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION;

EID: 0032768338     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Haque S, Chandra B, Gerber M, Lok S. Iron overload in patients with chronic hepatitis C: a clinicopathological study. Hum Pathol 1996;27:1277-81.
2. Piperno A, D'Alba R, Fargion S, Roffi L, Sampietro M, Parma S, et al. Liver iron concentration in chronic hepatitis: a study of 98 patients. Eur J Gastroenterol Hepatol 1995;7:1203-8.
3. Bonkowsky HL, Banner BF, Lambrecht RW, Rubin RB. Iron in liver disease other than hemochromatosis. Semin Liv Dis 1996;16:65-82.
4. Bonkowsky HL, Banner BF, Rothman AL. Iron and chronic viral hepatitis. Hepatology 1997;25:759-68.
5. Beinker N, Voigt M, Arendse M, Smit J, Stander I, Kirsch R.
6. Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C. J Hepatol 1996;25:633-8.
7. Kaji K, Nakanuma Y, Sasaki M, Unoura M, Kobayashi K, Nonomura A. Hemosiderin deposition in portal endothelial cells: a novel hepatic hemosiderosis frequent in chronic viral hepatitis B and C. Hum Pathol 1995;26:1080-4.
8. Deugnier Y, Boucher E. Iron and hepatitis viruses. Ital J Gastroenterol Hepatol 1998;30:467-9.
9. Piperno A. Classification and diagnosis of iron overload. Haematologica 1998;83:447-55.
10. Pietrangelo A. Metals, oxidative stress, and hepatic fibrogenesis. Semin Liver Dis 1996;16:13-30.
11. Smith B, Grove J, Guzail M, Day C, Daly A, Burt A, et al. Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C. Hepatology 1998;27:1695-9.
12. Piperno A, Sampietro M, D'Alba R, Roffi L, Fargion S, Parma S, et al. Iron stores, response to α-interferon therapy, and effects of iron depletion in chronic hepatitis C. Liver 1996;16:248-54.
13. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995:22:696-9.
14. Deugnier Y, Loreal O, Turlin B, Guyader D, Jouanolle H, Moirand R, et al. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 1992;102:2050-9.
15. Turlin B, Deugnier Y. Histological assessement of liver siderosis. J Clin Pathol 1997;50:971.
16. Feder J, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy D, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet 1996;13:399-408.
17. Carella M, D'Ambrosio L, Totaro A, Grifa A, Valentino M, Piperno A, Girelli D, Roetto A, Franco B, Gasparini P, Camaschella C. Mutation analysis of the HLA-H gene in Italian hemochromatosis patients. Am J Hum Genet 1997;60:828-32.
18. LeSage GD, Baldus WP, Fairbanks VF, Baggenstoss AH, McCall JT, Moore SB, et al. Hemochromatosis: genetic or alcohol-induced? Gastroenterology 1983;84:1471-7.
19. Adams PC, Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996;23:724-7.
20. Piperno A, Vergani A, Malosio I, Parma L, Fossati L, Ricci A, et al. Hepatic iron overload in patients with chronic viral hepatitis: role of HFE gene mutations. Hepatology 1998;28:1105-9.
21. Deugnier Y, Turlin B, Le Quilleuc D, Moirand R, Loréal O, Messner M, et al. A reappraisal of hepatic siderosis in patients with end-stage cirrhosis: practical implications for the diagnosis of hemochromatosis. Am J Surg Pathol 1997;21:669-75.
22. Barton AL, Banner BF, Cable EE, Bonkovsky HL. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol 1995;103:419-24.
23. Fargion S, Fracanzani AL, Sampietro M, Molteni V, Boldorini R, Mattioli M, et al. Liver iron influences the response to interferon alpha therapy in chronic hepatitis C. Eur J Gastroenterol Hepatol 1997;9:497-503.