Iron overload in patients with chronic hepatitis C: A clinicopathologic study

Human Pathology

Volumn 27, Issue 12, 1996, Pages 1277-1281

  Haque, S ^a   Chandra, B ^b   Gerber, M A ^b   Lok, A S F ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

alpha interferon; chronic hepatitis C; ferritin; hepatic iron; histological activity index

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; FERRITIN; IRON BINDING PROTEIN; TRANSFERRIN;

ADULT; ALCOHOLISM; ARTICLE; BLOOD TRANSFUSION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INFECTION RISK; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; RECURRENT DISEASE; RISK FACTOR;

EID: 0029834842     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(96)90337-8     Document Type: Article

References (25)

1. Fried MW, Hoofnagle JH: Therapy of hepatitis C. Semin Liver Dis 15:82-91, 1995
2. Tsubota A, Chayama K, Ikeda K, et al: Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology 19:1088-1094, 1994
3. Pagliaro L, Craxi A, Cammaa C, et al: Interferon-alpha for chronic hepatitis C: An analysis of pretreatment clinical predictors of response. Hepatology 19:820-828, 1994
4. Van Thiel DH, Friedlander L, Fagiuoli S, et al: Response to interferon alpha therapy is influenced by the iron content of liver. J Hepatol 20:410-415, 1994
5. Olynk JK, Reddy KR, Di Bisceglie AM, et al: Hepatic iron concentration as a predictor of response to Interferon alfa therapy in chronic hepatitis C. Gastroenterology 108:1104-1109, 1995
6. Britigan BE, SerodyJS, Cohen MS: The role of lactoferrin as an anti-inflammatory molecule. Adv Exp Med Biol 357:143-156, 1994
7. Finkelstein RA, Sciortino CV, McIntosh MA: Role of iron in microbe-host interaction. Rev Infect Dis 5:S759-S777, 1983
8. Ellison RT, Giehl TJ: Killing of gram negative bacteria by lactoferrin and lysozymes. J Clin Invest 88:1080-1091, 1991
9. Good MF, Powell LW, Halliday JW: Iron status and cellular immune competence. Blood Rev 2:43-49, 1988
10. De Vigiliis S, Cornacchia G, Sanna G, et al: Chronic liver disease in transfussion-dependent thalassemia: Liver iron quantitation and distribution. Acta Hematol 65:32-39, 1981
11. Donohue SM, Wonke B, Hoffbrand AV, et al: Alpha interferon in the treatment of chronic hepatitis C infection in thalassaemia major. Br J Hematol 83:491-497, 1993
12. Clemente MG, Congia M, Lai ME, et al: Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C. J Pediatr 125:123-128, 1994
13. Hayashi H, Takikawa T, Nishimura N, et al: Improvement of serum aminotransferase levels after phlebotomy in patients with chronic active hepatitis C and excess hepatic iron. Am J Gastroenterol 89:986-988, 1994
14. Knodell RG, Ishak KG, Black WC, et al: Formulation and application of a numerical scoring system for assessing histological activity in asympotomatic chronic active hepatitis. Hepatology 1:431-435, 1981
15. Brissot P, Bourel M, Herry D, et al: Assessment of liver iron content in 271 patients: A reevaluattion of direct and indirect methods. Gastroenterology 80:557-565, 1981
16. Bacon BR, Tavill AS: Role of the liver in normal iron metabolism. Semin Liver Dis 4:181-192, 1984
17. Milman N, Gradual NJ, Hegnhoj P, et al: Relationships among serum iron status markers, chemical and histochemical liver iron content in 117 patients with alcoholic and non-alcoholic hepatic disease. Hepatogastroenterol 41:20-24, 1994
18. Senba M, Nakamura T, Itakura H: Statistical analysis of relationship between iron accumulation and hepatitis B surface antigen. Am J Clin Pathol 84:340-342, 1985
19. Lustbader ED, Kann, HW, Blumberg BS: Serum ferritin as a predictor of host response to hepatitis B virus infection. Science 220:423-425, 1983
20. Zhou XD, DeTolla L, Custer RP, et al: Iron, ferritin, hepatitis B surface and core antigens in the livers of Chinese patients with hepatocellular carcinoma. Cancer 59:1430-1437, 1987
21. Arber N, Konikoff FM, Moshkowitz M, et al: Increased serum iron and iron saturation without liver iron accumulation distinguish chronic hepatitis C from other chronic liver diseases. Dig Dis Sci 39:2656-2659, 1994
22. Edwards CQ, Griffen LM, Goldgar P, et al: Prevalence of hemochromatosis among 11,065 presumably healthy blood donors. N Engl J Med 318:1355-1362, 1988
23. Deugnier Y, Margules S, Brissot P: Comparative study between biochemical and histological methods and image analysis in liver iron overload. J Clin Pathol 35:45-51, 1982
24. Deugnier YM, Turlin B, Powell LW, et al: Differentiation between heterozygotes and homozygotes in genetic hemochromatosis by means of histological hepatic iron index: A study of 192 cases. Hepatology 17:30-34, 1993
25. Barry M: Liver iron concentration, stainable iron and total body storage iron. Gut 15:411-415, 1974