Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells

British Journal of Cancer

Volumn 80, Issue 11, 1999, Pages 1718-1725

  Koning, G A ^a,c   Gorter, A ^b   Scherphof, G L ^a   Kamps, J A A M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

5 Fluorodeoxyuridine; Colon cancer; Drug delivery; Immunoliposomes; Monoclonal antibody; Tumour targeting

Indexed keywords

CHOLESTEROL; FLOXURIDINE DERIVATIVE; IMMUNOLIPOSOME; MONOCLONAL ANTIBODY; PALMITIC ACID DERIVATIVE; PHOSPHATIDYLCHOLINE; PRODRUG; TRITIUM;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG RELEASE; DRUG TARGETING; HUMAN; HUMAN CELL; INTERNALIZATION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL DIVISION; CHOLESTEROL; COLONIC NEOPLASMS; DRUG CARRIERS; FLOXURIDINE; HUMANS; IMMUNOTOXINS; KINETICS; LIPOSOMES; PALMITATES; PHOSPHATIDYLCHOLINES; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 0032767673     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690588     Document Type: Article

References (43)

1. Ahmad I, Longenecker M, Samuel J and Allen TM (1993) Antibody-targeted delivery of doxoruhiein entrapped in sterically stabilized liposomes can eradicate lung cancer in mice. Cancer Res 53: 1484-1488
2. Allen TM (1997) Liposomes: opportunities in drug delivery. Drugs 54; 8-14
3. Allen TM and Chonn A (1987) Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett 223: 42-46
4. Allen TM, Hansen C, Martin F, Redemann C and Yau Young A (1991) Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1066: 29-36
5. Beun GD, van Eendenburg DH, Corver WE, van de Velde CJ and Fleuren GJ (1992) T-cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. I. Significant bispecific lysis of syngeneic colon carcinoma CC531 is critically dependent on prolonged preactivation of effector T-lymphocytes by immobilized anti-T-cell receptor antibody. J Immunother 11: 238-248
6. Beun GD, Gorter A, Nooyen Y, van de Velde CJ and Fleuren GJ (1993) T cell retargeting using bispecific monoclonal antibodies in a rat colon carcinoma model. II. Syngeneic colon carcinoma CC531 is efficiently killed by retargeted cytotoxic T lymphocytes in vitro despite limited lysis in 51Cr release assays. J Immunol 150: 2305-2315
7. Böttcher CMF, Van Gent CM and Pries C (1961) A rapid and sensitive sub-micro phosphorus determination. Anal Chim Acta 24: 203-204
8. Danenberg PV (1977) Thymidylate synthetase a target enzyme in cancer chemotherapy. Biochim Biophyx Acta 473: 73-92
9. Derksen JTP, Morselt HWM and Scherphof GL (1988) Uptake and processing of immunoglobulin-coated liposomes by subpopulations of rat liver macrophages. Biochim Biophys Acta 971: 127-136
10. Derksen JTP and Scherphof GL (1985) An improved method for the covalent coupling of proteins to liposomes. Biochim Biophys Acta 814: 151-155
11. Dingemans KP, van den Bergh Weerman MA, Keep RF and Das PK (1994) Developmental slaves in experimental liver metastases: relation to invasiveness. Int J Cancer 57: 433-439
12. Ensminger WD, Rosowsky A, Raso V, Levin DC, Glode M, Come S, Steele G and Frei E (1978) A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2′-deoxyuridine and 5-fluorouracil Cancer Res 38: 3784-3792
13. Gregoriadis G (1995) Engineering liposomes for drug delivery: progress and problems. Trends Biotechnol 13: 527-537
14. Hoekstra D, Tomasini R and Scherphot GL (1980) Interactions of phospholipid vesicles with rat hepatocytes in vitro. Influence of vesicle-incorporated glycolipids. Biochim Biophys Acta 603: 336-346
15. Kamps JAAM, Swart PJ, Morselt HWM, Pauwels R, De Bethune MP, De Clercq E, Meijer DKF and Scherphof GL (1996) Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity. Biochim Biophys Acta 1278: 183-190
16. Kemeny NE (1995) Regional chemotherapy of colorectal cancer. Eur J Cancer 31A: 1271-1276
17. Kemeny N (1996) Colorectal cancer - An undertreated disease. Anti-Cancer Drugs 7: 1-7
18. Kinsky SC and Loader JE (1987) Circumvention of the methotrexate transport system by methotrexate-phosphalidylethanolamine derivatives: effect of fatty acid chain length. Biochim Biophys Acta 921: 96-103
19. 1. Pharm Res 12; 1775-1780
20. Lowry OH, Rosebrough NJ, Fan AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
21. Marinelli A, Dijkstra FR, van Dierendorick JH, Kuppen PJ, Cornelisse CJ and van de Velde CJ (1991) Effectiveness of isolated liver perfusion with mitomycin C in the treatment of liver tumours of rat colorectal cancer. Br J Cancer 64: 74-78
22. Marquet RL, Westbroek DL and Jeckel J (1984) Interferon treatment of a transplantable rat culon adenocarcinoma: importance of tumor site. Int J Cancer 33: 689-692
23. Martin FJ and Papahadjopoulos D (1982) Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting. J Biol Chem 257: 286-288
24. Maruyama K, Kennel SJ and Huang L (1990) Lipid composition is important for highly efficient target binding and retention of immunoliposomes. Proc Natl Acad Sci USA 87: 5744-5748
25. Mayer LD, Tai LC, Ko DS, Masin D, Ginsberg RS, Cullis PR and Bally MB (1989) Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res 49: 5922-5930
26. Meropol NJ, Creaven PJ and Petrelli NJ (1995) Metastatic colorectal cancer: advances in biochemical modulation and new drug development. Semin Oncol 22: 509-524
27. Mori A, Kennel SJ, Van Borssum Waalkes M, Scherphof GL and Huang L (1995) Characterization of organ specific immunoliposomes for delivery of 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine in a mouse lung-metastasis model. Cancer Chemother Pharmacol 35: 447-456
28. Myers CE (1981) The pharmacology of the fluoropyrimidines. Pharmacol Rev 33: 1-15
29. Nishizawa Y and Casida JE (1965) 3′,5′-diesters of 5-fluoro-2′-deoxyuridine: synthesis and biological activity. Biochem Pharmacol 14: 1605-1619
30. Papahadjopoulos D, Allen TM, Gabizon A, Mayhew E, Matthay K, Huang SK, Lee KD, Woodle MC, Lasic DD, Redemann C and Martin FJ (1991) Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci USA 88: 11460-11464
31. Petterson GL (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346-356
32. Scherphof GL (1991) In vivo behaviour of liposomes: Interactions with the mononuclear phagocyte system and implications for drug targeting. In: Handbook of Experimental Pharmacology. Juliano RL (ed), pp. 285-327. Springer Verlag: Berlin
33. Scherphof GL, Maruyama K, Van Borssum Waalkes M, Hoekstra D, Damen J, Kennel SJ and Huang L (1992) Lipid flow phenomena between liposomes, lipoproteins and cell membranes: applications in drug delivery. In: Liposome Dermatics. Braun-Falco O, Korting HC and Maibach HI (eds), pp. 11-19. Springer Verlag: Berlin
34. Scherphof GL, Kamps JAAM and Koning GA (1997) In vivo targeting of surface-modified liposomes to metastatically growing colon carcinoma cells and sinusoidal endothelial cells in the rat liver. J Liposome Res 7: 419-432
35. Schwendener RA. Supersaxo A, Rubas W, Weder HG, Hartmann MR, Schott H, Ziegler A and Hengartner H (1985) 5′-O-Palmitoyl- and 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine - novel lipophilic analogues of 5′-fluoro-2′-deoxyuridine: synthesis, incorporation into liposomes and preliminary biological results. Biochem Biophys Res Commun 126: 660-666
36. Storm G and Crommelin DJA (1997) Colloidal systems for tumor targeting. Hybridoma 16: 119-125
37. Supersaxo A, Ruhas W, Hartmann HR, Schott H, Hengartner H and Schwendener RA (1988) The antitumour effect of lipophilic derivatives of 5-fluoro-2′-deoxyuridine incorporated into liposomes. J Microencapsul 5: 1-11
38. Thomas C, Nijenhuis AM, Timens W, Kuppen PJ, Daemen T and Scherphof GL (1993) Liver metastasis model of colon cancer in the rat: immunohistochemical characterization. Invasion Metast 13: 102-112
39. Vaage J, Donovan D, Uster P and Working P (1997) Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma. Br J Cancer 75: 482-486
40. Vahrmeijer AL, van Dierendonck JH and van de Velde CJ (1995) Treatment of colorectal cancer metastases confined to the liver. Eur J Cancer 31A 1238-1242
41. Van Borssum Waalkes M and Scherphof GL (1990) Liposome-incorporated 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine as a slow-release antitumor drug depot in rat liver macrophages. Selective Cancer Ther 6: 15-22
42. Van Borssum Waalkes M, Fichtner I, Donijc B, Lemm M, Becker M, Arndt D and Scherphof GL (1992) In vivo distribution and antitumour activity of liposomal 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine. J Microencapsul 9: 335-346
43. Van Borssum Waalkes M, Van Galen M, Morselt HWM, Sternberg B and Scherphof GL (1993) In-vitro stability and cytostatic activity of liposomal formulations of 5-fluoro-2′-deoxyuridine and its diacylated derivatives. Biochim Biophys Acta 1148: 161-172