Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma

British Journal of Cancer

Volumn 75, Issue 4, 1997, Pages 482-486

  Vaage, J ^a   Donovan, D ^a   Uster, P ^b   Working, P ^b  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b ALZA CORPORATION   (United States)

Author keywords

Doxorubicin; Liposome; Pancreatic carcinoma

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; DOXORUBICIN; LIPOSOME; MACROGOL;

ANIMAL EXPERIMENT; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG FORMULATION; DRUG PENETRATION; DRUG UPTAKE; ENCAPSULATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; SIDE EFFECT; SLOW DRUG RELEASE; TUMOR XENOGRAFT;

EID: 0031045691     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.84     Document Type: Article

References (13)

1. Allen TM, Hansen C, Martin FJ, Redemann C and Yau-Young A (1991) Liposomes containing a synthetic lipid derivative of polyethylene glycol show prolonged circulation half-lives in vivo. Biochim Biophys Acta 1066: 29-36
2. Douglass HO Jr, Tepper J and Leichman L (1993) Neoplasms of the exocrine pancreas. In Cancar Medicine, 3rd edn Holland JF, Frei E III, Bast RC, Kufe DW, Morton DL and Weichselbaum RR (eds), pp. 1466-1484. Lea & Febiger: Philadelphia
3. Gabizon A, Goren D, Fuks Z, Meshorer A and Barenholz Y (1985) Superior therapeutic activity of liposome-associated Adriamycin in a murine metastatic tumor model. Br J Cancer 51: 681-689
4. Gabizon A, Price DC, Huberty J, Bresalier RS and Papahadjopoulos D. (1990). Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: biodistribution and imaging studies. Cancer Res 50: 6371-6378
5. Gabizon A, Chisin R, Amselem S, Druckmann S, Cohen R, Goren D, Fromer I, Petez T, Sulkes A and Barenholz Y (1991) Pharmacokinetic and imaging studies in patients receiving a formulation of liposome-associated adriamycin. Br J Cancer 64: 1125-1132
6. Huang SK, Lee K-D, Hong K, Friend DS and Papahadjopoulos D (1992) Microscopic localization of sterically stabilized liposomes in colon carcinorna-bearing mice. Cancer Res 52: 5135-5143
7. Nagata J, Yamauchi M, Takagi H, Kojima N, Hayashi Y and Yagi K (1990) Antitumor activity against human gastric cancers of sulfatide-inserled liposomes containing entrapped adriamycin. J Clin Biochem 8: 111-119
8. Papahadjopoulos D, Allen T, Gabizon A, Mayhew E, Matthay K, Huang SK, Lee K-D, Woodle MC, Lasic MC, Lasic DD and Redeman C (1991) Sterically stabilized liposoms: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc Natl Acad Sci USA 88: 11460-11464
9. Szoka FC (1991) Liposome drug delivery. In Membrane Fusian. Wilschut J. Hoekston R (eds), pp. 845-890. Marcel Dekker: New York
10. Vaage J, Mayhew E, Lasic D and Martin F (1992) Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes. Int J Cancer 51: 942-948
11. Vaage J, Donovan D, Mayhew E, Abra R and Huang A (1993) Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes. Cancer 72: 3671-3675
12. Vaage J, Barbera-Guillem E, Abra R, Huang A and Working P (1994) Tissue distribution and therapeutic effect of iztravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 73: 1478-1484
13. Vichi P and Tritton TR (1992) Adriamycin: protection from cell death by removal of extracellular drug. Cancer Res 52: 4135-4138