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During the preparation of this manuscript the enantioselective protonation of a samarium enolate in the presence of an achiral alcohol, soluble in perfluorohexane (stoichiometric), and a chiral alcohol, soluble in THF (0.16 mol-eq.), as a catalyst was reported. The ee value (max. 60%) was higher for reactions carried out in a fluorous biphase system than for those in THF (+ 11%). However, with a more enantioselective catalyst the same results were obtained (ee = 90%)
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During the preparation of this manuscript the enantioselective protonation of a samarium enolate in the presence of an achiral alcohol, soluble in perfluorohexane (stoichiometric), and a chiral alcohol, soluble in THF (0.16 mol-eq.), as a catalyst was reported. The ee value (max. 60%) was higher for reactions carried out in a fluorous biphase system than for those in THF (+ 11%). However, with a more enantioselective catalyst the same results were obtained (ee = 90%). S. Takeuchi, Y. Nakamura, Y. Ohgo, D. P. Curran, Tetrahedron Lett. 1998, 39, 8691-8694.
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