The relative proportions of secreted interleukin-2 and interleukin-10 determine the magnitude of rheumatoid arthritis T-cell proliferation to the recall antigen tuberculin purified protein derivative

Rheumatology

Volumn 38, Issue 12, 1999, Pages 1203-1207

  Corrigall, V M ^b,c   Garyfallos, A ^a   Panayi, G S ^b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

IL 10; IL 2; Recall antigens; T lymphocyte

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 2; TUBERCULIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

EID: 0032762555     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/38.12.1203     Document Type: Article

References (16)

1. Emery P, Panayi GS, Nouri AM. Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis. Clin Exp Immunol 1984;57:123-9.
2. Kingsley GH, Pitzalis C, Panayi GS. Abnormal lymphocyte reactivity to self major histocompatibility antigens in rheumatoid arthritis. J Rheumatol 1987;14:667-73.
3. Paimela L, Johansson-Stephansson EA, Koskimies S, Leurisalo-Repo M. Depressed cutaneous cell mediated immunity in early rheumatoid arthritis. Clin Exp Rheumatol 1990;8:433-7.
4. Cope AE, Londei M, Chu NR, Cohen SBA, Elliot MJ, Brennan FM et al. Chronic exposure to tumour necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell rcceptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest 1994;94:749-60.
5. De Waal Malefyt R, Haanen J, Spits HM, Roncarolo G, te Velda A, Figdor C et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human Tcell proliferation by diminishing the antigen presenting capacity of monocytes via down regulation of class II major histocompatability complex expression. J Exp Med 1991;174:915-24.
6. Taga K, Mostowski H, Tosato G. Human interleukin-10 can directly inhibit T cell growth. Blood 1993;81:2964-71.
7. Reiner SL, Wang Z, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis. Science 1993;259:1457-60.
8. Seiling PA, Modlin RL. Cytokine patterns at the site of mycobacterial infection. Immunol Biol 1994;191:378-87.
9. Schold D, Clercq E. Human immunodeficiency virus type 1 gp 120 induces anergy in human peripheral blood lymphocytes by inducing IL-10 production. J Virol 1996;70:4953-60.
10. Lapadula G, Iannone F, Dell'Accio F, Corellia M, Pipitone V. Interleukin-10 in rheumatoid arthritis. Clin Exp Rheumatol 1995;13:629-32.
11. Cicuttini FM, Byron KA, Maher D, Wootton AM, Muirden KD, Hamilton JA. Serum IL-4, IL-10 and IL-6 levels in inflammatory arthritis. Rheumatol Int 1995; 14:201-6.
12. Lacki JK, Klama K, Mackiewicz SH, Mackiewicz U, Muller W. Circulating interleukin-10 and interleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts: preliminary report. Inflamm Res 1995;44:24-6.
13. Cush JJ, Splawski JB, Thomas R, McFarlin J, Schulze-Koops H, Davis LS et al. Elevated interleukin-10 levels in patients with rheumatoid arthritis. Arthritis Rheum 1995;38:96-104.
14. Turner DM, Williams DM, Sankaram D, Lazarus M, Sinnot PJ, Hutchinson IV. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997;24:1-8.
15. Coakley G, Mok CC, Hajeer AH, Oilier WER, Turner D, Sinnott PJ et al. Interleukin-10 promotes polymorphisms in rheumatoid arthritis and Felty's syndrome. Br J Rheumatol 1998;37:988-91.
16. Keijers V, Verweij CL, Westendorp RGJ, Breedveld FC, Huizinger TWJ. IL-10 polymorphisms in relation to production and rheumatoid arthritis. Arthritis Rheum 1997;Abstract 891.