CD99 positivity and EWS-FLI1 gene rearrangement identify a breast tumor in a 60-year-old patient with attributes of the Ewing family of neoplasms

Diagnostic Molecular Pathology

Volumn 8, Issue 3, 1999, Pages 120-124

  Sezer, Ohran ^a   Jugovic, Dragana ^b   Blohmer, Jens U ^a   Turzynski, Andreas ^a   Thiel, Gundula ^a   Langelotz, Corinna ^a   Possinger, Kurt ^a   Kovar, Heinrich ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

Breast tumor; M; RT PCR; Translocation (11; 22)

Indexed keywords

CD99 ANTIGEN; TRANSCRIPTION FACTOR;

ADULT; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BONE; BREAST TUMOR; CANCER FAMILY; CASE REPORT; CHROMOSOME TRANSLOCATION; DIAGNOSTIC VALUE; EWING SARCOMA; EXON; FEMALE; GENE FUSION; GENE REARRANGEMENT; HUMAN; INTRON; KARYOTYPING; ONSET AGE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SMALL CELL SARCOMA; SOFT TISSUE; SOUTHERN BLOTTING; TUMOR LOCALIZATION;

ADOLESCENT; ADULT; ANTIGENS, CD; BONE NEOPLASMS; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; EXONS; FEMALE; GENE REARRANGEMENT; HUMANS; KARYOTYPING; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEIN C-FLI-1; SARCOMA, EWING'S; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0032759439     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199909000-00003     Document Type: Article

References (27)

1. Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer Kuntschik M. MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 1991;67:1886-93.
2. Argani P, Perez-Ordonez B, Xiao H, Caruana SM, Huvos AG, Ladanyi M. Olfactory neuroblastoma is not related to the Ewing family of tumors: absence of EWS/FLI1 gene fusion and MIC2 expression. Am J Surg Pathol 1998;22:391-8.
3. Charney DA, Charney JM, Ghali VS, Teplitz C. Primitive neuroectodermal tumor of the myocardium: a case report, review of the literature, immunohistochemical, and ultrastructural study. Hum Pathol 12-1996;27:1365-9.
4. De Alava E, Kawai A, Healey JH, et al. EWS-FLI1 fusion transcript stucture is an independent determinant of prognosis in Ewings sarcoma. J Clin Oncol 1998;16:1248-55.
5. Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors - a subgroup of small-round-cell tumors defined by specific chimeric transcripts [see comments]. N Engl J Med 1994;331: 294-9.
6. Katz RL, Quezado M, Senderowicz AM, Villalba L, Laskin WB, Tsokos M. An intra-abdominal small round cell neoplasm with features of primitive neuroectodermal and desmoplastic round cell tumor and a EWS/FLI-1 fusion transcript. Hum Pathol 1997;28: 502-9.
7. Kawauchi S, Fukuda T, Miyamoto S, et al. Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA [In Process Citation], Am J Surg Pathol 11-1998; 22:1417-22.
8. Kovar, H. Progress in the molecular biology of Ewing tumors. Sarcoma 1998;2:3-17.
9. Kovar H, Aryee DN, Jug G, et al. EWS/FLI-1 antagonists induce growth inhibition of Ewing tumor cells in vitro. Cell Growth Differ 1996;7:429-437.
10. Kovar H, Dworzak M, Strehl S, et al. Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. Oncogene 1990;5:1067-70.
11. Kovar H, Zoubek A, Gadner H. A long way from the definition of the molecular basis to benefit in the clinical management of Ewing tumours. Onkologie 1996;19:234-40.
12. Lawlor ER, Mathers JA, Bainbridge T, et al. Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis. J Clin Oncol 3-1998;16:1150-7.
13. Marley EF, Liapis H, Humphrey PA, et al. Primitive neuroectodermal tumor of the kidney - another enigma: a pathologic, immunohistochemical, and molecular diagnostic study. Am J Surg Pathol 1997;21:354-9.
14. Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ES. Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene 1995;11:1049-54.
15. Quezado M, Benjamin DR, Tsokos M. EWS/FLI-1 fusion transcripts in three peripheral primitive neuroectodermal tumors of the kidney. Hum Pathol 1997;28:767-71.
16. Schmidt D, Herrmann C, Jurgens H, Harms D. Malignant peripheral neuroectodermal tumor and its necessary distinction from Ewing's sarcoma. A report from the Kiel Pediatric Tumor Registry. Cancer 1991;68:2251-9.
17. Sheaff M, McManus A, Scheimberg I, Paris A, Shipley J, Baithun S. Primitive neuroectodermal tumor of the kidney confirmed by fluorescence in situ hybridization. Am J Surg Pathol 1997;21: 461-8.
18. Sorensen PH, Wu JK, Berean KW, et al. Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma. Proc Natl Acad Sci USA 1996;93:1038-43.
19. Takeuchi T, Iwasaki H, Ohjimi Y, et al. Renal primitive neuroectodermal tumor: a morphologic, cytogenetic, and molecular analysis with the establishment of two cultured cell lines. Diagn Mol Pathol 12-1997; 6:309-17.
20. Tanaka K, Iwakuma T, Harimaya K, Sato H, Iwamoto Y. EWS-F1i1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells. J Clin Invest 1997; 99:239-47.
21. Toretsky JA, Connell Y, Neckers L, Bhat NK. Inhibition of EWS-FLI-1 fusion protein with antisense oligodeoxynucleotides. J Neurooncol 1997;31:9-16.
22. Tsuji S, Hisaoka M, Morimitsu Y, et al. Peripheral primitive neuroectodermal tumour of the lung: report of two cases [In Process Citation]. Histopathology 10-1998;33:369-74.
23. Verrill MW, Judson IR, Harmer CL, Fisher C, Thomas JM, Wiltshaw E. Ewing's sarcoma and primitive neuroectodermal tumor in adults: are they different from Ewing's sarcoma and primitive neuroectodermal tumor in children? J Clin Oncol 1997;15:2611-21.
24. Zoubek A, Dockhorn Dworniczak B, Delattre O, et al. Does expression of different EWS chimeric transcripts define clinically distinct risk groups of Ewing tumor patients? J Clin Oncol 1996; 14:1245-51.
25. Zoubek A, Pfleiderer C, Salzer-Kuntschik M, et al. Variability of EWS chimaeric transcripts in Ewing tumours: a comparison of clinical and molecular data. Br J Cancer 11-1994;70:908-13.
26. Zucman-Rossi J, Legoix P, Victor JM, Lopez B, Thomas G. Chromosome translocation based on illegitimate recombination in human tumors. Proc Natl Acad Sci USA 9-29-1998;95:11786-91.
27. Zucman J, Melot T, Desmaze C, et al. Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J 1993;12:4481-7.