Development of a lyophilized kit formulation for labeling of DNA probes with 99mTc

International Journal of Pharmaceutics

Volumn 190, Issue 2, 1999, Pages 197-205

  Hjelstuen, O K ^a   Saetern, A M ^b   Tonnesen H H ^a   Bremer, P O ^c   Verbruggen, A M ^d  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

^c Isopharma AS   (Norway)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Lyophilization; Oligonucleotides; Radiopharmaceutical; Stability; Technetium 99m

Indexed keywords

MERTIATIDE TC 99M; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE; TARTARIC ACID DERIVATIVE; TECHNETIUM 99M; TECHNETIUM TIN COLLOID TC 99M;

ARTICLE; CHELATION; CONJUGATION; DNA PROBE; FREEZE DRYING; ISOTOPE LABELING; OXIDATION; PH; PRIORITY JOURNAL; SHELF LIFE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PROBES; DRUG STABILITY; FREEZE DRYING; ISOTOPE LABELING; RADIONUCLIDE GENERATORS; RADIOPHARMACEUTICALS; TARTRATES; TECHNETIUM; TEMPERATURE; TIN COMPOUNDS;

EID: 0032759371     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00293-8     Document Type: Article

References (21)

1. Biassoni L., D'Andrea V., Biancari F., Santoni F., Dibra A., De Antoni E. Radiolabelled monoclonal antibodies in clinic and surgical oncology: a review. Panminerva Med. 39:1997;46-52.
2. Chianelli M., Mather S.J., Martin-Comin J., Signore A. Radiopharmaceuticals for the study of inflammatory processes: a review. Nucl. Med. Commun. 18:1997;437-455.
3. de Kieviet W. Technetium radiopharmaceuticals: chemical characterization and tissue distribution of Tc-glucoheptonate using Tc-99m and carrier Tc-99. J. Nucl. Med. 22:1981;703-709.
4. Dewanjee M.K., Ghafouripour A.K., Kapadvanjawala M., Dewanjee S., Serafini A.N., Lopez D.M., Sfakianakis G.N. Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J. Nucl. Med. 35:1994;1054-1063.
5. Dykes C.W. Genes; disease and medicine. Br. J. Clin. Pharmacol. 42:1996;683-695.
6. Fischman A.J., Babich J.W., Strauss H.W. A ticket to ride: peptide radiopharmaceuticals. J. Nucl. Med. 34:1993;2253-2263.
7. Griffiths G.L., Goldenberg D.M., Jones A.L., Hansen H.J. Radiolabeling of monoclonal antibodies and fragments with technetium and rhenium. Bioconjugate Chem. 3:1992;91-99.
8. Hilger C.S., Willis M.C., Wolters M., Pieken W.A. Tc-99m-labeling of modified RNA. Nicolini M., Mazzi U. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. 1999;SGE Editoriali, Italy.
9. 99mTc-labeling and biodistribution of a CAPL antisense oligodeoxynucleotide. Nucl. Med. Biol. 25:1998a;651-657.
10. m-labelled oligodeoxynucleotide to CAPL RNA. Nucl. Med. Commun. 19:1998b;803-812.
11. Hjelstuen O.K., By B.C., Cleynhens B., Ormstad H.M., Roald T.E., Tønnesen H.H., Bremer P.O., Verbruggen A.M. Comparative evaluation of 99mTc-MAG2-oligodeoxynucleotides with phosphodiester and phosphorothioate backbones: preparation; stability and biodistribution. J. Labelled Compd. Radiopharm. 42:1999;737-760.
12. Hnatowich D.J., Winnard P. Jr, Virzi F., Fogarasi M., Sano T., Smith C.L., Cantor C.R., Rusckowski M. Technetium-99m labeling of DNA oligonucleotides. J. Nucl. Med. 36:1995;2306-2314.
13. Mælandsmo G.M., Hovig E., Skrede M., Engebraaten O., Flørenes V.A., Myklebost O., Grigorian M., Lukanidin E., Scanlon K.J., Fodstad Ø. Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme. Cancer Res. 56:1996;5490-5498.
14. Romano G., Claudio P.P., Kaiser H.E., Giordano A. Recent advances; prospects and problems in designing new strategies for oligonucleotide and gene delivery in therapy. In Vivo. 12:1998;59-68.
15. Schering Aktiengesellschaft, 1995. Conjugates made of metal complexes and oligonucleotides. Patent No. PCT/EP95/02539, 30 June.
16. Stalteri M., Zhang Y.M., Mather S.J. Technetium labelled C-MYC antisense DNA: preparation and in vitro hybridization. Nicolini M., Mazzi U. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine. 1999;SGE Editoriali, Italy.
17. Tavitian B., Terrazzino S., Kühnast B., Marzabal S., Stettler O., Dollé F., Deverre J.R., Jobert A., Hinnen F., Bendriem B., Crouzel C., Di Giamberardino L. In vivo imaging of oligodeoxynucleotides with positron emission tomography. Nat. Med. 4:1998;467-471.
18. Tewson T.J., Krohn K.A. PET radiopharmaceuticals: state-of-the-art and future prospects. Semin. Nucl. Med. 28:1998;221-234.
19. Uhlmann E., Peyman A. Antisense oligonucleotides: a new therapeutic principle. Chem. Rev. 90:1990;544-584.
20. Winnard Jr P., Chang F., Ruskowski M., Mardirossian G., Hnatowich D.J. Preparation and use of NHS-MAG3 for technetium-99m labeling of DNA. Nucl. Med. Biol. 24:1997;425-432.
21. Zhang Y.M., Stalteri M.A., Mather S.J. Technetium labelled c-myc oncogene mRNA antisense oligonucleotide: preparation and in vitro characterisation. Eur. J. Nucl. Med. 24:1997;870. (abstract).