Membrane-based cell culture technologies: A scientifically and economically satisfactory alternative to malignant ascites production for monoclonal antibodies

Research in Immunology

Volumn 149, Issue 6, 1998, Pages 557-559

  Marx, U ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

ANTIBODY PRODUCTION; ASCITES; BIOREACTOR; CELL CULTURE; CONTROLLED STUDY; COST; MEMBRANE; PERFUSION; PRIORITY JOURNAL; REVIEW;

EID: 0032109046     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(98)80006-0     Document Type: Article

References (5)

1. Falkenberg, F.W. et al. (1995), In vitro production of monoclonal antibodies in high concentration in a new and easy to handle modular minifermenter. J. Immunol. Methods, 179, 13-29.
2. Hendriksen, C., Rozing, J., van der Kamp, M. & de Leeuw, W. (1996), The production of monoclonal antibodies: are animals still needed? ATLA, 24, 109-110.
3. Jackson, L.R., Trudel, L.J., Fox, J.G. & Lipman, N.S. (1996), Evaluation of hollow fibre bioreactors as an alternative to murine ascites production for small scale monoclonal antibody production. J. Immunol. Methods, 189, 217-231.
4. Köhler, G. & Milstein, C. (1975), Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 256, 495-497.
5. Marx, U., Embleton, M.J., Fischer, R., Gruber, F.P., Hansson, U., Heuer, J., de Leeuw, W.A., Logtenberg, T., Merz, W., Portetelle, D., Romette, J.-L. & Straughan, D.W. (1997), Monoclonal Antibody Production. The Report and Recommendations of ECVAM Workshop 23. ATLA, 25, 121-137.