Differential effects of losartan and doxazosin on vascular function in senescent spontaneously hypertensive rats

American Journal of Hypertension

Volumn 12, Issue 11 I, 1999, Pages 1105-1108

  Maeso, R ^a   Navarro Cid, J ^a   Rodrigo, E ^a   Ruilope, L M ^a   Lahera, V ^a   Cachofeiro, V ^a  

^a SCHOOL OF MEDICINE   (Spain)

Author keywords

Aging; Endothelium; Hypertension; Vasorelaxation

Indexed keywords

ACETYLCHOLINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; DOXAZOSIN; DRINKING WATER; LOSARTAN; NITRATE;

AGING; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HYPERTENSION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SENESCENCE; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM;

EID: 0032757784     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(99)00086-2     Document Type: Article

References (15)

1. J.G. De Mey D.D. Gray Endothelium-dependent reactivity in resistance vessels Prog Appl Microcirc 88 1985 181 187
2. L. Linder W. Kiowki F.R.R. Bühler L.F. Luscher Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo blunted response in essential hypertension Circulation 81 1990 1762 1767
3. R. Maeso E. Rodrigo R. Muñoz-Garcı́a Chronic treatment with losartan ameliorates vascular dysfunction induced by aging in spontaneously hypertensive rats J Hypertens 16 1998 665 672
4. S. Taddei A. Virdis P. Mattei Aging and endothelial function in normotensive subjects and essential hypertension patients Circulation 91 1995 1981 1987
5. C.F. Küng T.F. Lüscher Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta Hypertension 14 1995 S42 S48
6. 1 receptor antagonist on endothelial dysfunction induced by aging in SHR. Kidney Int 1998;54(Suppl 8):S30–S35.
7. H. Hayakawa L. Raij The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension Hypertension 29 part 2 1997 235 241
8. E.L. Schiffrin L.Y. Deng Comparison of effects of angiotensin I-converting enzyme inhibition and beta-blockade for 2 years on function of small arteries from hypertensive patients Hypertension 25 1995 699 703
9. J.R. Cockcroft F.J. Chowienczyk N. Reniamin Preserved endothelium-dependent vasodilation in patients with essential hypertension N Engl J Med 330 1994 1036 1040
10. Tojo A, Kobayashi N, Kimura K, et al: Effects of antihypertensive drugs on nitric oxide synthase activity in rat kidney. Kidney Int 1996;49:S138–S140.
11. 1-adrenergic antihypertensive agent Am J Hypertens 7 1994 159 164
12. S. Rajagopalan S. Kurz T. Munzel M. Tarpey B.A. Freeman K.K. Griendling D.G. Harrison Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone J Clin Invest 97 8 1996 1916 1923
13. V. Cachofeiro R. Maeso E. Rodrigo Nitric oxide and prostaglandins in the prolonged effects of losartan and ramipril in hypertension Hypertension 26 1995 236 243
14. R. Maeso J. Navarro-Cid R. Muñoz-Garcı́a Losartan reduces phenylephrine constrictor response in aortic rings from spontaneously hypertensive rats. Role of nitric oxide and angiotensin II type 2 receptors Hypertension 28 1996 967 972
15. Lang M, Noll G, Lüscher TF: Effect of aging and hypertension on contractility of resistance arteries: modulation by endothelial factors. Am J Physiol 1995;269:H837–H844.