Systematic mutagenesis of TCR complementarity-determining region 3 residues: A single conservative substitution dramatically improves response to both multiple HLA-DR alleles and peptide variants

Journal of Immunology

Volumn 163, Issue 9, 1999, Pages 4946-4952

  Brawley, James V ^b   Concannon, Patrick ^a  

^a BENAROYA RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; PEPTIDE DERIVATIVE;

ALLELE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CHIMERA; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RECEPTOR AFFINITY; T LYMPHOCYTE;

ADENINE; ALLELES; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CLONE CELLS; CONSERVED SEQUENCE; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, DOMINANT; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; GUANINE; HLA-DR ANTIGENS; HUMANS; JURKAT CELLS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; POINT MUTATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT FUSION PROTEINS;

EID: 0032757549     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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