Relationships between alterations in glutathione metabolism and the disposition of inorganic mercury in rats: Effects of biliary ligation and chemically induced modulation of glutathione status

Chemico-Biological Interactions

Volumn 123, Issue 3, 1999, Pages 171-195

  Zalups, Rudolfs K ^a   Barfuss, Delon W ^b   Lash, Lawrence H ^c  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA STATE UNIVERSITY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Accumulation and excretion of mercury; Biliary ligation; Glutathione depletion; Kidneys; Liver; Rats

Indexed keywords

ACIVICIN; BUTHIONINE SULFOXIMINE; GAMMA GLUTAMYLTRANSFERASE; MALEIC ACID DIETHYL ESTER; MERCURY;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT OBSTRUCTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG TISSUE LEVEL; DRUG URINE LEVEL; GLUTATHIONE METABOLISM; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; NONHUMAN; RAT;

ANIMALS; BILE DUCTS; BUTHIONINE SULFOXIMINE; FECES; GLUTATHIONE; ISOXAZOLES; KIDNEY; LIVER; MALE; MALEATES; MERCURY; RATS; RATS, SPRAGUE-DAWLEY;

ZEA MAYS;

EID: 0032757210     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00135-0     Document Type: Article

References (26)

1. Zalups R.K., Barfuss D.W., Lash L.H. Disposition of inorganic mercury following biliary obstruction and chemically-induced glutathione depletion: dispositional changes one hour after the intravenous administration of mercuric chloride. Toxicol. Appl. Pharmacol. 154:1999;135-144.
2. Zalups R.K., Lash L.H. Depletion of glutathione in the kidney and the renal disposition of administered inorganic mercury. Drug Metab. Dispos. 25:1997;516-523.
3. Scott R.D., Curthoys N.P. Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism. Am. J. Physiol. 252:1987;F877-F882.
4. Grifffith O.W., Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-N-butyl homocysteine sulfoximine). J. Biol. Chem. 254:1979;7558-7560.
5. Baggett J.M., Berndt W.O. The effect of depletion of non-protein sulflhydryls by diethyl maleate plus buthionine sulfoximine on renal uptake of mercury in the rat. Toxicol. Appl. Pharmacol. 83:1986;556-562.
6. Fariss M.W., Reed D.J. High-performance liquid chromatography of thiols and disulfides: dinitrophenyl derivatives. Methods Enzymol. 143:1987;101-109.
7. Rabenstein D.L. Metal complexes of glutathione and their biological significance. Dolphin D., Auramovibc O., Poulson R. Coenzymes and Cofactors. Glutathione: Chemical, Biochemical and Medical Aspects. 3:1989;147-186 Wiley, New York.
8. Zalups R.K., Lash L.H. Recent advances in the study of transport and toxicity of mercury in the kidney. J. Toxicol. Environ. Health. 42:1994;144.
9. Berndt W.O., Baggett J.M., Blacker A., Houser M. Renal glutathione and mercury uptake by kidney. Fundam. Appl. Toxicol. 5:1985;832-839.
10. deCeaurriz J., Payan J.P., Morel G., Brondeau M.T. Role of extracellular glutathione and γ-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J. Appl. Toxicol. 14:1994;201-206.
11. Tanaka T., Naganuma A., Imura N. Role of γ-glutamyltranspeptidase in renal uptake and toxicity of inorganic mercury in mice. Toxicology. 60:1990;187-198.
12. Zalups R.K. Organic anion transport and action of γ-glutamyltranspeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol. Appl. Pharmacol. 132:1995;289-298.
13. Zalups R.K. Basolateral uptake of mercuric conjugates of N-acteylcysteine and cysteine in the kidney involves the organic anion transport system. J. Toxicol. Environ. Health. 55:1998;13-29.
14. Zalups R.K., Barfuss D.W. Accumulation and handling of inorganic mercury in the kidney after coadministration with glutathione. J. Toxicol. Environ. Health. 44:1995;385-399.
15. Zalups R.K., Barfuss D.W. Renal disposition of mercury in rats after intravenous injection of inorganic mercury and cysteine. J. Toxicol. Environ. Health. 44:1995;401-413.
16. Zalups R.K., Barfuss D.W. Participation of mercuric conjugates of cysteine, homocysteine and N-acetylcysteine in mechanisms involved in the renal tubular uptake of inorganic mercury. J. Am. Soc. Nephrol. 9:1998;551-561.
17. Zalups R.K., Lash L.H. Binding of mercury in renal brush-border and basolateral membrane-vesicles: implication of a cysteine-conjugate of mercury involved in the luminal uptake of inorganic mercury in the kidney. Biochem. Pharmacol. 53:1997;1889-1900.
18. Ballatori N., Clarkson T.W. Inorganic mercury secretion into bile as a low molecular weight complex. Biochem. Pharmacol. 33:1984;1087-1092.
19. Ballatori N., Clarkson T.W. Dependence of biliary secretion of inorganic mercury on the biliary transport of glutathione. Biochem. Pharmacol. 33:1984;1093-1098.
20. Gregus Z., Stein A.F., Varga F., Klaassen C.D. Effect of lipoic acid on biliary excretion of glutathione and metals. Toxicol. Appl. Pharmacol. 114:1992;88-96.
21. Wong K.-L., Klaassen C.D. Relationship between liver and kidney levels of glutathione and metallothionein. Toxicology. 19:1981;39-47.
22. Gregus Z., Stein A.F., Klaassen C.D. Effect of inhibition of γ-glutamyltranspeptidase on biliary and urinary excretion of glutathione-derived thiols and methylmercury. J. Pharmacol. Exp. Ther. 242:1987;27-32.
23. Stein A.F., Gregus Z., Klaassen C.D. Species variations in biliary excretion of glutathione-related thiols and methylmercury. Toxicol. Appl. Pharmacol. 93:1988;351-359.
24. Abbott W.A., Meister A. Intrahepatic transport and utilization of biliary glutathione and its metabolites. Proc. Natl. Acad. Sci. USA. 83:1986;1246-1250.
25. Cornell J.S., Meister A. Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rats jejunal mucosa. Proc. Natl. Acad. Sci. USA. 73:1976;420-422.
26. Lash L.H., Jones D.P., Anders M.W. Glutathione homeostasis and glutathione S-conjugate toxicity in the kidney. Rev. Biochem. Toxicol. 9:1988;29-67.