Inhibition of thymopoiesis of CD34+ cell maturation by HIV-1 in an in vitro CD34+ cell and thymic epithelial organ culture model

Stem Cells

Volumn 17, Issue 6, 1999, Pages 327-338

  Knutsen, Alan P ^a   Roodman, Stanford T ^b   Freeman, John J ^a   Mueller, Kathleen R ^a   Bouhasin, John D ^a  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD34+ stem cells; Fetal thymic epithelial organ culture; HIV; Thymopoiesis

Indexed keywords

CD34 ANTIGEN;

ARTICLE; CELL MATURATION; GROWTH INHIBITION; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOPENIA; T LYMPHOCYTE SUBPOPULATION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

EID: 0032757205     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.170327     Document Type: Article

References (42)

1. Ho DD, Neumann AU, Perelson AS et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-126.
2. Douek DC, McFarland RD, Kelser PH et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998;396:690-695.
3. Boldt-Houle DM, Jamieson BD, Aldrovandi GM et al. Loss of T cell receptor Vbeta repertoires in HIV type 1-infected SCID-hu mice. AIDS Res Hum Retrovir 1997;13:125-134.
4. Godfrey DI, Zlotnik A. Control points in early T-cell development. Immunol Today 1993;14:547-553.
5. + stem cells cocultured with thymic epithelia from children with AIDS. STEM CELLS 1996;14:533-547.
6. + stem cells from HIV-seropositive hemophiliacs in cultured thymic epithelial fragments. STEM CELLS 1996;14:132-145.
7. - cells in postnatal allogeneic cultured thymic epithelia to evaluate immunodeficiency disorders. STEM CELLS 1996;14:702-713.
8. + cells in an in vitro thymic epithelia organ coculture model. Int J Immunopharmacol 1999;21:15-26.
9. Uittenbogaart CH, Anisman DJ, Jamieson BD et al. Differential tropism of HIV-1 isolates for distinct subsets in vitro. AIDS 1996;10:F9-F16.
10. + UT-7 megakaryocytic human cell line becomes highly HIV-1 and HIV-2 susceptible upon CXCR4 transfection: induction of cell differentiation by HIV-1 infection. Blood 1997;89:2670-2678.
11. Schuurman H-J, van Baarlen J, Krone WJA et al. The thymus in the acquired immunodeficiency syndrome: pathological and theoretical consideration. In: Kendall MD, Ritter MA, eds. Thymus Update. Chur, Switzerland: Harwood Academics Publishers, 1998:171-189.
12. Savino WM, Dardenne M, Marche C et al. Thymic epithelium in AIDS: an immunohistologic study. Am J Pathol 1985;122:302-307.
13. Seemayer TA, Laroche AC, Goldman HY. Precocious thymic involution manifest by epithelial injury in the acquired immune deficiency syndrome. Hum Pathol 1984;15:469-474.
14. Schuurman JJ, Krone WJA, Broekhuizen R et al. The thymus in AIDS. Am J Pathol 1989;134:1329-1338.
15. Numazaki K, Goldman H, Bai X-Q et al. Effects of infection by HIV-1, cytomegalovirus, and human measles virus on cultured human thymic epithelial cells. Microbiol Immunol 1989;33:733-745.
16. + (T4) lymphocyte depletion. Proc Natl Acad Sci USA 1990;87:7727-7731.
17. Schnittman SM, Singer KH, Greenhouse JJ et al. Thymic microenvironment induces HIV infection. Physiologic secretion of IL-6 by thymic epithelial cells up-regulates virus expression in chronically infected cells. J Immunol 1991;147:2553-2558.
18. Hays EF, Uittenbogaart CH, Brewer JC et al. In vitro studies of HIV-1 expression in thymocytes from infants and children. AIDS 1992;6:265-272.
19. McCune J, Kaneshima H, Krowka J et al. The SCID-hu mouse: a small animal model for HIV infection and pathogenesis. Ann Rev Immunol 1991;9:399-429.
20. Aldrovandi GM, Feuer G, Gao L et al. The SCID-hu mouse as a model for HIV-1 infection. Nature 1993;363:732-736.
21. Bonyhadi ML, Rabin L, Salimi S et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-732.
22. Stanley SK, McCune JM, Kaneshima H et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 1993;178:1151-1163.
23. Kollman TR, Kim A, Pettoello-Mantovani M et al. Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice. J Immunol 1995;154:907-921.
24. Withers-Ward ES, Amado RG, Koka PS et al. Transient renewal of thymopoiesis in HIV-infected human implants following antiviral therapy. Nat Med 1997;3:1102-1109.
25. Kitchen SG, Uittenbogaart CH, Zack JA. Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from CD4-positive precursor allows productive infection. J Virol 1997;71:5713-5722.
26. Kitchen SG, Zack JA. CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection in the thymus. J Virol 1997;71:6928-6934.
27. Berkowitz RD, Beckerman KP, Schall TJ et al. CXCR4 and CCR5 expression delineates targets for HIV-1 disruption of T cell differentiation. J Immunol 1998;161:3702-3710.
28. Zaitseva MB, Lee S, Rabin RL et al. CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection. J Immunol 1998;161:3103-3113.
29. Deichmann M, Kronenwett R, Haas R. Expression of the human immunodeficiency virus type-1 coreceptors CXCR-4 (fusin, LESTR) and CKR-5 in CD34+ hematopoietic progenitor cells. Blood 1997;89:3522-3528.
30. Jenkins M, Hanley MB, Moreno MB et al. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Blood 1998;91:2672-2676.
31. + bone marrow stem cells are infected with HIV in a subset of seropositive individuals. J Immunol 1992;149:689-697.
32. + hematopoietic progenitor cells are not a major reservoir of the human immunodeficiency virus. Blood 1990;76:1281-1286.
33. Steinberg HN, Crumpacker CS, Chatis PA. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J Virol 1991;65:1765-1769.
34. +) hematopoietic progenitor cells. Arch Virol 1992;122:271-280.
35. +) hematopoietic progenitors in human immune deficiency virus-1 seropositive thrombocytopenic individuals. Blood 1992;79:2680-2687.
36. + hematopoietic progenitors express low levels of CD4, the high-affinity receptor for human immunodeficiency virus-type 1. Blood 1994;84:1896-1905.
37. + hematopoietic progenitors. Pathobiology 1996;64:53-58.
38. Kearns K, Bahner I, Bauer G et al. Suitability of bone marrow from HIV-1 infected donors for retrovirus-mediated gene transfer. Hum Gene Ther 1997;8:301-311.
39. Weichold FF, Zella D, Barabitskaja O et al. Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most-primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures. Blood 1998;91:907-915.
40. + progenitor cells: CXCR and CCR5 chemokine receptor expression and infectivity by HIV. J Immunol 1998;161:4169-4176.
41. + cells. Apoptosis 1997;2:61-68.
42. + T lymphocytes from HIV-infected individuals is mediated by FasL and tumor necrosis factor. J Exp Med 1997;185:55-64.