Insulin and insulin-like growth factor-I and- II modulate human granulosa-lutein cell steroidogenesis: Enhancement of steroidogenic acute regulatory protein (StAR) expression

Molecular Human Reproduction

Volumn 5, Issue 11, 1999, Pages 1003-1010

  Devoto, Luigi ^a,c   Christenson, Lane K ^a   McAllister, Jan M ^b   Makrigiannakis, Antonis ^a   Strauss III, Jerome F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c 1354 BRB II/III ^*  (United States)

Author keywords

Granulosa cell; Human steroidogenesis; Insulin like growth factors; Steroidogenic acute regulatory protein

Indexed keywords

8 BROMO CYCLIC AMP; INSULIN; PROGESTERONE; REGULATOR PROTEIN; SOMATOMEDIN B; SOMATOMEDIN C;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FERTILIZATION; GENE ACTIVATION; GENETIC TRANSFECTION; GRANULOSA CELL; HUMAN; HUMAN CELL; LUTEAL CELL; PRIORITY JOURNAL; PROGESTERONE SYNTHESIS; PROMOTER REGION; PROTEIN EXPRESSION; STEROIDOGENESIS;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CYCLIC AMP; FEMALE; GENE EXPRESSION REGULATION; GRANULOSA CELLS; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; LUTEAL CELLS; PHOSPHOPROTEINS; RNA, MESSENGER;

EID: 0032757056     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/5.11.1003     Document Type: Article

References (31)

1. Adashi, E.V., Resnick, C.E., Hernandez, E.R. et al. (1998) Insulin-like growth factor-1 as an amplifier of follicle-stimulating hormone action: studies on the mechanism(s) and site(s) of action in cultured rat granulosa cell. Endocrinology, 122, 1583-1591.
2. Adashi, E.Y., Resnick, C.E., D'Ercole, J.A. et al. (1985) Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr. Rev., 3, 400-420.
3. Arakane, F., King, S., Du, Y. et al. (1997) Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J. Biol. Chem., 272, 32656-32662.
4. Balasubramanian, K., Lavoie, H.A., Garmey, J.C. et al. (1997) Regulation of porcine granulosa cell steroidogenic acute regulatory protein (StAR) by insulin-like growth factor I: Synergism with follicle-stimulating hormone or protein kinase A agonist. Endocrinology, 138, 433-439.
5. Christenson, L.K., Johnson, P.F., McAllister, J.M. et al. (1999) CCAAT/ enhancer binding proteins (C/EBP) regulate expression of the human steroidogenic acute regulatory protein (StAR) gene. J. Biol. Chem., 274, 26691-26698.
6. de Moura, M.D., Choi, D., Adashi, E.Y. et al. (1997) Insulin-like growth factor I-mediated amplification of follicle-stimulating hormone-supported progesterone accumulation by cultured rat granulosa cells: Enhancement of steroidogenesis enzyme activity and expression. Biol. Reprod., 56, 946-953.
7. De Neubourg, D., Robins, A., Fishel, S. and Delbeke, L. (1998) Quantification of insulin-like growth factor I receptors on granulosa cells with flow cytometry after follicular stimulation. Hum. Reprod., 13, 161-164.
8. Devoto, L., Kohen, P., Vega, M. et al. (1995) Multi hormonal regulation of progesterone synthesis in cultured human mid luteal cells. J. Clin. Endocrinol. Metab., 5, 1566-70.
9. El-Roeiy, A., Chen, X., Roberts, V.J. et al. (1994) Expression of the genes encoding the insulin-like growth factors,the IGF and insulin receptors,and IGF-binding proteins-1-6 and the localization of their gene products in normal and polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 78, 1488-1496.
10. Golos, T.G. and Strauss. J.F. III (1988) 8-bromoadenosine cyclic 3′,5′-phosphate rapidly increases 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in human granulosa cells: role of cellular sterol balance in controlling the response to tropic stimulation. Biochemistry, 27, 3503-3506.
11. Gougeon, A. (1996) Regulation of ovarian follicular development in primates: facts and hypotheses. Endocrine Rev., 17, 121-155.
12. Guidice, L.C. (1992) Insulin-like growth factors and ovarian follicular development. Endocrine Rev., 13, 641-669.
13. Hernandez, E.R., Hurwitz, A., Vera, A. et al. (1992) Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary. J. Clin. Endocrinol. Metab., 74, 419-425.
14. Jones, J.J. and Clemmons, D.R. (1995) Insulin-like growth factors and their binding proteins: biological action. Endocr. Rev., 16, 3-34.
15. Kiriakidou, M., McAllister, J.M., Sugawara, T. et al. (1996) Expression of steroidogenic acute regulatory protein (StAR) in the human ovary. J. Clin. Endocrinol. Metab., 81, 4122-4128.
16. Kol, S., Ben-Shlomo, I., Ando, M. and Adashi, E.Y. (1997) Insulin-like growth factor I affects the intraovarian interleukin-1 system: evidence for suppression of type I interleukin-1 receptor expression and enhancement of secretory phospholipase A2 expression and activity. Mol. Hum. Reprod., 3, 1095-1099.
17. La Voie, H.A., Garmey, J.C. and Veldhuis, J.D. (1999a) Mechanisms of insulin-like growth factor I augmentation of follicle-stimulating hormone-induced porcine steroidogenic acute regulatory protein gene promoter activity in granulosa cells. Endocrinology, 140, 146-153.
18. La Voie, H., Garmey, J.C., Day, R. et al. (1999b) Concerted regulation of low density lipoprotein receptor gene expression by follicle-stimulating hormone and insulin-like growth factor I in porcine granulosa cells: promoter activation, messenger ribonucleic acid stability, and sterol feedback. Endocrinology, 140, 178-186.
19. Makrigiannakis, A., Coukos, G., Christofidou-Solomidou, M. et al. (1999) N-cadherin-mediated human granulosa cell adhesion prevents apoptosis. Am. J. Pathol., 154, 1391-1406.
20. Mason, H.D., Cwyfan-Hughes, S.C., Heinrich, G. et al. (1996) Insulin like growth factor (IGF) I and II, IGF-binding protein proteases are produced by theca and stroma of normal and polycystic ovaries. J. Clin. Endocrinol. Metab., 81, 276-284.
21. McAllister, J.M., Manson, I.J., Byrd, W. et al. (1990) Proliferating human granulosa-lutein cells in long term monolayer culture: expression of aromatase, cholesterol side-chain cleavage, and 3β hydroxysteroid dehydrogenase. J. Clin. Endocrinol. Metab., 71, 26-33.
22. Miller, W.L. (1988) Molecular biology of steroid hormone synthesis. Endocr. Rev., 9, 9255-318.
23. Mimuro, T., Smith, H., Iwashita, M., Illingworth, P.J. (1998) The somatostatin analogue, octreotide, modifies both steroidogenesis and IGFBP-1 secretion in human luteinizing granulosa cells. Hum. Reprod., 13, 150-153.
24. Stocco, D.M. and Clark, B.J. (1996) Regulation of the acute production of steroids in steroidogenic cells Endocr. Rev., 17, 221-244.
25. Strauss, J.F. III, Kallen, C., Christenson, L.K. et al. (1999) The steroidogenic acute regulatory protein (StAR): a window into the complexities of intracellular cholesterol trafficking. Rec. Progr. Horm. Res., 54, 369-395.
26. Sugawara, T., Kiriakidou, M., McAllister, J.M. et al. (1997) Multiple steroidogenic factor 1 binding elements in the human steroidogenic acute regulatory protein gene 5′-flanking region are required for maximal promoter activity and cyclic AMP responsiveness. Biochemistry, 36, 7249-7255.
27. van Dessel, H.J.H.M., Chandrasekher, Y.A., Yap, O.W.S. et al. (1996) Serum and follicular fluid levels of insulin-like growth factor-I(IGF-I),(IGF-II), and IGF-binding protein-1 and 3 during the normal menstrual cycle. J. Clin. Endocrinol. Metab., 81, 1224-1231.
28. Willis, D. and Franks, S. (1995) Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin like-growth factor receptor. J. Clin. Endocrinol. Metab., 80, 3788-3790.
29. Willis, D., Manson, H. and Watson, H. (1998) Developmentally regulated responses of human granulosa cells to insulin-like growth factors (IGFs): IGF-I and IGF-II action mediated via the Type-I receptor. J. Clin. Endocrinol Metab., 83, 1256-1259.
30. Yuan, W. and Guidice, L.C. (1999) Insulin-like growth factor-II mediates the steroidogenic and growth promoting actions of follicle stimulating hormone on human ovarian pre-antral follicles cultured in vitro. J. Clin. Endrocrinol. Metab., 84, 1479-1482.
31. Zhang, F.P., El-Hafnawy, T. and Hubtaniemi, I. (1998) Regulation of luteinizing hormone receptor gene expression by insulin-like growth factor-I in an immortalized murine leydig tumor cell line (BLT-1) Biol. Reprod., 59, 1116-1123.