Does the degree of penicillin susceptibility of Streptococcus pneumoniae affect the bactericidal activity of co-amoxiclav versus oral cephalosporins at physiological concentrations? An in vitro pharmacodynamic simulation

Journal of Chemotherapy

Volumn 11, Issue 5, 1999, Pages 345-348

  Prieto, J ^a   Gimenez M J ^b   Balcabao, I P ^a   Gomez lus M L ^a   Aguilar, Lorenzo ^b  

^a SCHOOL OF MEDICINE   (Spain)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Bactericidal activity; Oral lactams; Streptococcus pneumoniae

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; CEFACLOR; CEFPODOXIME; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; PENICILLIN G;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM COLONY; CONTROLLED STUDY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACODYNAMICS; STREPTOCOCCUS PNEUMONIAE;

EID: 0032757034     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.1999.11.5.345     Document Type: Article

References (17)

1. th generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci. Clin Microbiol Infect 1997; 3 (Suppl.1): S48-S60.
2. Fenoll A, Martin Bourgon C, Muñoz R, Vicioso D, Casal J. Serotype, distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing systemic infections in Spain 1979-1989. Rev Infect Dis 1991; 13: 56-60.
3. th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, D.C.: American Society for Microbiology, 1997: 132.
4. Pallares R, Liñares J, Vadillo M, et al. Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain. N Engl J Med 1995; 333: 474-80.
5. Eagle H. Speculations as to the therapeutic significance of the penicillin blood level. Ann Intern Med 1948; 28: 260-8.
6. Friedland IR, McCraken GH. Management of infections caused by antibiotic-resistant Streptococcus pneumoniae. N Engl J Med 1994; 331: 377-82.
7. Jacobs M. Respiratory tract infections: epidemiology and surveillance. J Chemother 1997; 9 (Suppl.3): 10-7.
8. Balcabao IP, Aguilar L, Martin M, García Y, Dal-Ré R, Prieto J. Activities against Streptococcus pneumoniae of amoxicillin and cefotaxime at physiological concentrations: in vitro pharmacodynamic simulation. Antimicrob Agents Chemother 1996; 40: 2904-6.
9. Adam D, De Visser I, Koeppe P. Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination. Antimicrob Agents Chemother 1982; 22: 353-7.
10. Fraschini F, Scaglione F, Falchi M et al. Pharmacokinetics and tissue distribution of amoxicillin plus clavulanic acid after oral administration in man. J Chemother 1990; 2: 171-7.
11. Barbhaiya RH, Shukla UA, Gleason CR, Shyu WC, Pittman KA. Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor. Antimicrob Agents Chemother 1990; 34: 1210-3.
12. Tremblay D, Dupront A, Ho C, Coussediere D, Lenfant B. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses. J Antimicrob Chemother 1990; 26 (Suppl. E): 21-8.
13. Konishi K, Suzuki H, Hayashi M, Saruta T. Pharmacokinetics of cefuroxime axetil in patients with normal and impaired renal function. J Antimicrob Chemother 1993; 31: 413-20.
14. Thorburn CE, Knott SJ, Edwards DI. In vitro activities of oral β-lactams at concentrations achieved in humans against penicillin susceptible and -resistant pneumococci and potential to select resistance. Antimicrob Agents Chemother 1998; 42: 1973-9.
15. García de Lomas J, y Grupo Español para Vigilancia de Patógenos Respiratorios. Situación epidemiológica actual y resistencia de los patógenos respiratorios en España. Med Clin (Barc) 1998; 110 (Supl 1): 44-51.
16. rd ed. Approved standard M7-A3. National Committee for Clinical Laboratory Standards, Villanova, Pa 1993.
17. Martin M, Gómez-Lus ML, Aguilar L, Martinez P, Giménez MJ, Prieto J. Effect of clavulanic acid and/or polymorphonuclear neutrophils on amoxicillin bactericidal activity against Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis 1997; 16: 512-6.