Effect of cyclodextrins and polymers on triclosan availability and substantivity in toothpastes in vivo

Journal of Pharmaceutical Sciences

Volumn 88, Issue 12, 1999, Pages 1254-1258

  Loftsson, Thorsteinn ^a   Leeves, Nigel ^a   Bjornsdottir, Birna ^a   Duffy, Lisa ^a   Masson, Mar ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; CHLORHEXIDINE; CYCLODEXTRIN; GAMMA CYCLODEXTRIN; POLYMER; TOOTHPASTE; TRICLOSAN;

ARTICLE; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG SOLUBILITY; SOLUBILIZATION;

EID: 0032756266     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js9902466     Document Type: Article

References (22)

1. Hull, P. Chemical inhibitation of plaque. J. Clin. Periodontol. 1980, 7, 431-442.
2. Gilbert, R. J.; Williams, P. E. O. The oral retention of antiplaque efficacy of triclosan in human volunteers. Br. J. Clin. Pharmacol. 1987, 23, 579-583.
3. Addy, M.; Jenkins, S.; Newcombe, R. Toothpastes containing 0.3% and 0.5% triclosan. II. Effects of single brushings on salivary bacterial counts. Am. J. Dent. 1989, 2, 215-219.
4. Cummins, D.; Creeth, J. E. Delivery of antiplaque agents from dentifrices, gels, and mouthwashes. J. Dent. Res. 1992, 71, 1439-1449.
5. Jenkins, S.; Addy, M.; Newcombe, R. G. Dose response of chlorhexidine against plaque and comparison with triclosan. J. Clin. Periodontol. 1994, 21, 250-255.
6. Jones, M. N.; Song, Y. H.; Kaszuba, M.; Reboiras, M. D. The interaction of phospholipid liposomes with bacteria and their use in the delivery of bactericides. J. Drug Targeting 1997, 5, 25-34.
7. Renvert, S.; Birkhed, D. Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora. J. Clin. Periodontol. 1995, 22, 63-70.
8. Creeth, J. E.; Abraham, P. J.; Barlow, J. A.; Cummins, D. Oral delivery and clearance of antiplaque agents from triclosan-containing dentrifrices. Int. Dent. J. 1993, 43, 387-397.
9. Loftsson, T.; Brewster, M. E. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J. Pharm. Sci. 1996, 85, 1017-1025.
10. Stella, V. J.; Rajewski, R. A. Cyclodextrins: their future in drug formulation and delivery. Pharm. Res. 1997, 14, 556-567.
11. Masson, M.; Loftsson, T.; Masson, G.; Stefansson, E. Cyclodextrins as permeation enhancers: some theoretical evaluations and in vitro testing. J. Controlled Release 1999, 59, 107-118.
12. Loftsson, T. Increasing the cyclodextrin complexation of drugs and drug biovailability through addition of water-soluble polymers. Pharmazie 1998, 53, 733-740.
13. Higuchi, T.; Connors, K. A. Phase-solubility techniques. Adv. Anal. Chem. Instrum. 1965, 4, 117-212.
14. Gilbert, R. J.; Fraser, S. B.; van der Ouderaa, F. J. G. Oral disposition of triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether) delivered from dentifrice. Caries Res. 1987, 21, 29-36.
15. Rajewski, R. A.; Stella, V. J. Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery. J. Pharm. Sci. 1996, 85, 1142-1168.
16. Loftsson, T.; Stefánsson, E. Effect of cyclodextrins on topical drug delivery to the eye. Drug Devel. Ind. Pharm. 1997, 23, 473-481.
17. Loftsson, T.; Bodor, N. The effect of cyclodextrins on percutaneous transport of drugs. In Percutaneous penetration enhancers; Smith, E. W., Maibach, H. I., Eds.; CRC Press: Boca Raton, FL, 1995; pp 335-342.
18. Loftsson, T.; Järvinen, T. Cyclodextrins in ophthalmic drug delivery. Adv. Drug Deliv. Rev. 1999, 36, 59-79.
19. Tomaski, P.; Schilling, C. H. Complexes of starch with organic guests. In Advances in carbohydrate chemistry and biochemistry, Vol. 53; Horton, D., Ed.; Academic Press: San Diego, CA, 1998; pp 345-426.
20. Afflitto, J.; Fakhry-Smith, S.; Gaffar, A. Salivary and plaque triclosan levels after brushing with a 0.3% triclosan/copolymer/ NaF dentifrice. Am. J. Dent. 1989, 2, 207-210.
21. Simon, W. Mathematical techniques for physiology and medicine; Academic Press: New York, 1972.
22. Dawes, C. A mathematical model of salivary clearance of sugar from the oral cavity. Caries Res. 1983, 17, 321-334.