Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E2 production in response to pro-inflammatory signals

European Journal of Immunology

Volumn 29, Issue 11, 1999, Pages 3793-3803

  Graf, Beth A ^a   Nazarenko, Daniel A ^a   Borrello, Melinda A ^a,b   Roberts, L Jackson ^c   Morrow, Jason D ^c   Palis, James ^a   Phipps, Richard P ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

B macrophage cell; COX 2; Inflammation; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN M; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; B-LYMPHOCYTES; BLOTTING, WESTERN; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROST; DINOPROSTONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; ISOENZYMES; MACROPHAGES; MEMBRANE PROTEINS; MICE; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 0032752893     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199911)29:11<3793::AID-IMMU3793>3.0.CO;2-3     Document Type: Article

References (43)

1. Hanecak, R., Zovich, D., Pattengale, P. and Fan, H., Differentiation in vitro of a leukemia virus-induced B-cell lymphoma into macrophages. Mol. Cell. Biol. 1989. 9: 2264-2268.
2. Boyd, A. and Schrader, J., Derivation of macrophage-like lines from the pre-B lymphoma ABLS 8.1 using 5-azacytidine. Nature 1982. 297: 691-693.
3. Martin, M., Strasser, A., Baumgarth, N., Cicuttini, F., Welch, K., Salvaris, E. and Boyd, A., A novel cellular model of switching between the pre-B cell and myelomonocytic lineages. J. Immunol. 1993. 150: 4395-4406.
4. Sohn, C., Sheibani, K., Winberg, C. and Rappaport, H., Monocytoid B lymphocytes: Their relation to the patterns of the acquired immunodeficiency syndrome (AIDS) and AIDS-relaled lymphadenopathy. Hum. Pathol. 1985. 16: 979-984.
5. Seremetis, S., Pelicci, P.-G., Tabilio, A., Ubriaco, A., Grignani, F., Cuttner, J., Winchester, R., Knowles, D. and Dalla-Favera, R., High frequency of clonal immunoglobulin of T cell receptor gene rearrangements in acute myelogenous leukemia. J. Exp. Med. 1987. 165: 1703-1712.
6. Liu, Y.-C., Cleveland, R., Madelaire, C. and Hines, J., Discordant immunophenotype of chronic B-cell lymphoproliferative disorders in simultaneous specimens from bone marrow and peripheral sites. Arch. Pathol. Lab. Med. 1995. 119: 53-58.
7. Borrello, M. and Phipps, R., Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics. J. Immunol. 1995. 155: 4155-4161.
8. + B lymphocytes and macrophages. Immunol. Today 1996. 17: 471-475.
9. Smith, W. and DeWitt, D., Prostaglandin endoperoxide H synthases-1 and -2. Adv. Immunol. 1996. 62: 167-215.
10. Smith, W., Garavito, R. and DeWitt, D., Prostaglandin endoperoxide H synthases. J. Biol. Chem. 1996. 271: 33157-33160.
11. Phipps, R., Stein, S. and Roper, R., A new view of prostaglandin E regulation of the immune response. Immunol. Today 1991. 12: 349-352.
12. 2 regulation of the immune response. Adv. Prostaglandin Thromboxane Leukot. Res. 1994. 22: 101-111.
13. Lumley, P., Humphrey, P., Kennedy, I. and Coleman, R., Comparison of the potencies of some prostaglandins as vasodilators in three vascular beds of the dog. Eur. J. Pharm. 1982. 81: 421-430.
14. 1 synthesis. J. Immunol. 1992. 149: 2984-2991.
15. 2-dependent induction of B cell unresponsiveness. Role of surface Ig and Fc receptors. J. Immunol. 1989. 143: 2127-2132.
16. 2. J. Immunol. 1987. 138: 1074-1081.
17. Santoli, D., Phillips, P., Colt, T. and Zurier, R., Supression of IL-2-dependent human T cell growth in vitro by prostaglandin E and their precursor fatty acids. J. Clin. Invest. 1990. 85: 424-432.
18. 2 induction of granulocyte-macrophage colony-stimulating factor secretion by cloned murine helper T cells. J. Immunol. 1989. 142: 813-818.
19. 2 acts at two distinct pathways of T lymphocyte activation: Inhibition of IL-2 production and down regulation of transferrin receptor expression. J. Immunol. 1985. 135: 1172-1179.
20. Van der Pouw Kraan, T., Boeije, L., Smeenk, R., Wijdenes, J. and Aarden, L., Prostaglandin E2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 1995. 181: 775-779.
21. Seitz, M., Loetscher, P., Dewald, R., Towbin, H. and Baggiolini, M., Opposite effects of IL-13 and IL-12 on the release of inflammatory cytokines, cytokine inhibitors and prostaglandin E from synovial fibroblasts and blood mononuclear cells. Eur. J. Immunol. 1996. 26: 2198-2202.
22. 2 promotes B lymphocyte Ig isotype switching to IgE. J. Immunol. 1995. 154: 162-170.
23. Morita, I., Schindler, M., Regier, M., Otto, J., Hori, T., DeWitt, D. and Smith, W., Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J. Biol. Chem. 1995. 270: 10902-10908.
24. Regier, M., DeWitt, D., Schindler, M. and Smith, W., Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch. Biochem. Biophys. 1993. 301: 439-444.
25. Siebert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L. and Isakson, P., Pharmacological and biochemical demonstration of the role of cyclcoxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 1994. 91: 12013-12017.
26. DuBois, R. N., Awad, J., Morrow, J., Roberts, L. J. and Bishop, P. R., Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor alpha and phorbol ester. J. Clin. Invest. 1994. 93: 493-498.
27. Zhang, Y., Cao, J., Graf, B., Meekins, H., Smith, T. and Phipps, R. P., CD40 engagement upregulates cyclooxygenase 2 expression and prostaglandin E2 production in human lung fibroblasts. J. Immunol. 1998. 160: 1053-1057.
28. Bikah, G., Carey, J., Ciallella, J., Tarakhovsky, A. and Bondada, S., CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. Science 1996. 274: 1906-1909.
29. Lagoo, A. and Sell, S., Early activation and cell cycle entry of resting B cells after Fab-anti-lg treatment: Role of receptor crosslinking. Cell. Immunol. 1989. 118: 53-67.
30. Wortis, H., Teutsch, M., Higer, M., Zheng, J. and Parker, D., B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B-cell phenotypes. Proc. Natl. Acad. Sci. USA 1995. 92: 3348-3352.
31. Ricote, M., Li, A., Willson, T., Kelly, C. and Glass, C., The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998. 391: 79-86.
32. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 1995. 83: 803-812.
33. Kliewer, S., Lenhard, J., Willson, T., Patel, I., Morris, D. and Lehmann, J., A prostaglandin 12 metabolite binds peroxisome proliferator-activated receptor g and promotes adipocyte differentiation. Cell 1995. 83: 813-819.
34. Riese, J., Hoff, T., Nordhoff, A., DeWitt, D., Resch, K. and Kaever, V., Transient expression of prostaglandin endoperoxide synthase-2 during mouse macrophage activation. J. Leukoc. Biol. 1994. 55: 476-482.
35. Daugelat, S. and Kaufmann, H., Role of Th1 and Th2 cells in bacterial infections. Chem. Immunol. 1996. 63: 66-97.
36. Robinson, D. and Kay, A., Role of Th1 and Th2 cells in human allergic disorders. Chem. Immunol. 1996. 63: 187-203.
37. Ranger, A., Das, M., Kuchroo, V. and Glimcher, L., B7-2 is essential for the development of IL-4-producing T cells. Int. Immunol. 1996. 8: 1549-1560.
38. Crery, W., Diaz-Mitoma, F., Filion, L. and Kumar, A., Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype. Eur. J. Immunol. 1996. 26: 1273-1277.
39. Plytycz, B. and Seljelid, R., B-1/macrophages as 'Living Fossils'. Immunol. Today 1997. 18: 505.
40. Plytyz, B. and Seljelid, R., Dual origin of lymphocytes. Immunol. Today 1999. 20: 53.
41. Castle, B. E., Kishimoto, K., Stearns, C., Brown, M. L. and Kehry, M. R., Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 1993. 151: 1777-1788.
42. O'Banion, M., Winn, V. and Young, D., cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc. Natl. Acad. Sci. USA 1992. 89: 4888-4892.
43. Bauer, S., Holmes, K., Morse, H. and Potter, M., Clonal relationship of the lymphoblastic cell line P388 to the macrophage cell line P388D1 as evidenced by immunoglobulin gene rearrangements and expression of cell surface antigens. J. Immunol. 1986. 136: 4695-4699.