Intracellular hyperinsulinism: A metabolic characteristic of obesity with and without type 2 diabetes - Intracellular insulin in obesity and Type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 46, Issue 3, 1999, Pages 231-237

  Benzi, L ^a   Ciccarone, A M ^d   Cecchetti, P ^c   Dicianni, G ^d   Caricato, F ^a   Trincavelli, L ^b   Volpe, L ^a   Navalesi, R ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Neurbio Farmacology B ^*  (Italy)

^c INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Intracellular insulin; Obesity; Type 2 diabetes mellitus

Indexed keywords

INSULIN;

ARTICLE; CELL LEVEL; GLUCOSE TRANSPORT SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HYPERINSULINISM; INSULIN RESISTANCE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOGENESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; HUMANS; HYPERINSULINISM; INSULIN; INTRACELLULAR MEMBRANES; MIDDLE AGED; MONOCYTES; OBESITY; OSMOLAR CONCENTRATION; RECEPTOR, INSULIN;

EID: 0032752315     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(99)00100-X     Document Type: Article

References (21)

1. Duckworth W.C. Insulin degradation: mechanisms, products and significance. Endocrine. Rev. 9:1988;319-345.
2. Benzi L., Trischitta V., Ciccarone A.M., Cecchetti P., Brunetti A., Squatrito S., Marchetti P., Vegneri R., Navalesi R. Improvement with Metformin in insulin internalization and processing in monocytes from NIDDM patients. Diabetes. 39:1990;844-849.
3. Trischitta V., Brunetti A., Chiavetta A., Benzi L., Papa V., Vigneri R. Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients. Diabetes. 38:1989;1579-1584.
4. Ueda M., Robinson F.W., Smith M.M., Kono T. Effect of monensin on insulin processing in adipocytes: evidence that the internalized insulin-receptor complex has some physiogical activities. J. Biol. Chem. 260:1985;3941-3949.
5. Cyneberg L., Aussel C., Vaubourdolle M., Agneray J., Ekindjian O.G. Modulation of insulin action of 2-deoxyglucose uptake by chloroquine in chick embryo fibroblasts. Diabetes. 36:1987;27-34.
6. National Diabetes Data Group @ Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979; 28: 1039-1057.
7. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. Suppl. 97:1986;77-89.
8. Benzi L., Pezzino V., Marchetti P., Gullo D., Cecchetti P., Masoni A., Vigneri R., Navalesi R. A14-125I monoiodoinsulin purified by different high-performance liquid chromatographic procedures and by polyacrylamide gel electrophoresis: preparation, immunochemical properties and receptor binding affinity. J. Chromatogr. 378:1986;337-347.
9. Trischitta V., Gullo D., Squatrito S., Pezzino V., Goldfine I.D., Vigneri R. Insulin internalization into monocytes is decreased in patients with type II diabetes mellitus. J. Clin. Endocrinol. Metab. 62:1986;522-528.
10. Benzi L., Cecchetti P., Ciccarone A.M., Pilo A., Di Cianni G., Navalesi R. Insulin degradation in vitro and in vivo: A comparative stydy in men. Diabetes. 43:1994;297-304.
11. Cuatrecasas P. Isolation of the insulin receptor of liver and fat-cell membranes. Proc. Natl. Acad. Sci. 69:1988;318-322.
12. Levy J.R., Olefsky J.M. Intracellular insulin-receptor dissociation and segregation in a rat fibroblast cell line transfected with a human insulin receptor gene. J. Biol. Chem. 263:1988;6101-6108.
13. Sesti G., D'alfonzo R., Vargas Punti M.D., Tullio A.N., Liu Y.Y., Federici M., Borboni P., Marini M.A., Lauro R. Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured Epstein-Barr virus-transformed lymphocytes from insulin-resistant subjects. Diabetologia. 39:1996;289-297.
14. Benzi L., Cecchetti P., Ciccarone A.M., Nardone A., Merola E., Maggiorelli R., Campi F., Di Cianni G., Navalesi R. Inhibition of endosomal acidification in normal cells mimics the derangements of cellular insulin and insulin-receptor metabolism observed in non-insulin-dependent diabetes mellitus. Metabolism. 46:1997;1259-1265.
15. Bevan A.P., Krook A., Tikerpae J., Seabright P., Siddle K., Smith G.D. Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes. J. Biol. Chem. 272:1997;26833-26840.
16. Ueda M., Robinson F.W., Smith M.M., Kono T. Effects of monensin on insulin processing in adipocytes: evidence that the internalized insulin-receptor complex has some physiological activities. J. Biol. Chem. 260:1985;3941-3950.
17. Cynober L., Aussel C., Vaubourdolle M., Agneray J., Akindjian O.G. Modulation of insulin action of 2-deoxyglucose uptake by cloroquine in chick embryo fibroblasts. Diabetes. 36:1987;27-36.
18. Smith G.D., Amos T.A.S., Mahler R., Peters T.J. Effect of chloroquine on insulin and glucose homeostasis in normal subjects and patients woth non-insulin-dependent. Br. Med. J. 294:1987;465-467.
19. Bennett R.G., Hamel F.G., Duckworth W.C. Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex. Diabetes. 46:1997;197-203.
20. Stenz F.B., Harris H.L., Kitabchi A.E. Early detection of degraded A14-125I-insulin in human fibroblasts by the use of high performance liquid chromatography. Diabetes. 32:1983;474-477.
21. Jochen A.L., Berhanu P., Olefsky J.M. Insulin internalization and degradation in adipocytes from normal and Type 2 diabetic subjects. J. Clin. Endocrinol. Metab. 62:1986;268-274.