Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig

Journal of Veterinary Pharmacology and Therapeutics

Volumn 22, Issue 5, 1999, Pages 327-332

  Wechsung, E ^a   Houvenaghel, A ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

SAH 63 675; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; COUGHING; DEPRESSION; DIGESTIVE SYSTEM ELECTROPHYSIOLOGY; ELECTRIC ACTIVITY; FEMALE; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; LARGE INTESTINE; LEUKOCYTE COUNT; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RESTLESSNESS; SHIVERING; SMALL INTESTINE; STOMACH ANTRUM; SWINE; TACHYPNEA; VOMITING;

ANIMALS; ELECTRODES; ELECTROPHYSIOLOGY; FEMALE; FURANS; HEMODYNAMIC PROCESSES; HYPOTENSION; INFUSIONS, INTRAVENOUS; INTESTINES; LEUKOCYTE COUNT; PLATELET ACTIVATING FACTOR; PYLORIC ANTRUM; SHIVERING; SWINE; SWINE, MINIATURE; VOMITING;

ANIMALIA; SUS SCROFA;

EID: 0032751139     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1999.00228.x     Document Type: Article

References (40)

1. Bardon, T. & Derégnaucourt, J. (1985) Effects of platelet activating factor (PAF) on the digestive motility in the conscious rat. Digestive Diseases and Sciences, 30, 758.
2. Bar-Natan, M.F., Wilson, M.A., Spain, D.A. & Garrison, N.R. (1995) Platelet-activating factor and sepsis-induced small intestinal microvascular hypoperfusion. Journal of Surgical Research, 58, 38-45.
3. Bradley, L.M., Goldstein, R.E., Feuerstein, G. & Czaja, J.F. (1989) Circulatory effects of PAF-acether in newborn piglets. American Journal of Physiology. 256, H205-H212.
4. von Bruchhausen, F. (1997) Pathological aspects of platelet-activating factor (PAF), Platelets and their Factors, 126, 645-718.
5. Curtin, M.L. (1998) Current status of platelet-activating factor antagonists. Expert Opinion on Therapeutic Patents, 8, 703-711.
6. De Sacdeleer, V., Wechsung, E. & Houvenaghel, A. (1991) Endotoxin in the conscious piglet: its effects on some general and gastrointestinal myoelectrical parameters. Veterinary Research Communications, 15, 227-238.
7. 2 on gastrointestinal electrical activity in the concious piglet. Prostaglandins Leukotrienes and Essential Fatty Acids, 45, 67-70.
8. 2α, on gastrointestinal activity in the conscious piglet. Prostaglandins Leukotrienes and Essential Fatty Acids, 45, 71-75.
9. Debek, W., Chyczewski, L. & Makarewicz, M. (1998) Platelet-activating factor receptor-antagonist (BN 52021) stabilizes the oxidative-antioxidative balance and attenuates the morphological changes in the gastrointestinal tract in experimental hemorrhagic shock. Experimental and Toxicologic Pathology. 50, 19-25.
10. Denizot, Y., Chaussade, S., Nathan, N., Couturier, D. & Benveniste, J. (1992) PAF-acether and the gastrointestinal tract. European Journal of Gastroenterology and Hepatology. 4, 871-876.
11. Dobrowsky, R.T., Voyksner, R.D. & Olson, N.C. (1991) Effect of SR1 63-675 on hemodynamics and blood PAF levels during porcine endotoxemia. American Journal of Physiology, 260, H1455-H1465.
12. Ephgrave, K., Kremer, T., Broadhurst, K. & Cullen, J. (1997) The role of platelet-activating factor in conscious, normotensive endotoxemia. Journal of Surgical Renearch, 68, 170-174.
13. Esplugues, J.V. & Whittle, B.J.R. (1989) Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. American Journal of Physiology, 256, G275-G282.
14. Feuerstein, G., Rabinovici, R., Leor, J., Winkler, J.D. & Vonhof, S. (1997) Platelet-activating factor and cardiac diseases: therapeutic potential for PAF inhibitors. Journal of Lipid Mediators and Cell Signalling, 15, 255-284.
15. Heuer, H.O., Letts, G. & Meade, C.J. (1990) Tumor necrosis factor (TNF) and endotoxin prime effects of PAF in vivo. Journal of Lipid Mediators and Cell Signalling, 2, S101-S108.
16. Hogaboam, C.M. & Wallace, J.L. (1994) Intestinal PAF synthesis: the role of the mast cell. Journal of Lipid Mediators, 10, 103-105.
17. Imaizumi, T., Stafforini, D.M., Yamada, Y., McIntyre, T.M., Prescott, S.M. & Zimmerman, G.A. (1995) Platelet-activating factor: a mediator for clinicians. Journal of Internal Medicine, 238, 5-20.
18. Izzo, A.A. (1996) PAF and the digestive tract. A review. Journal of Pharmacy and Pharmacology, 48, 1103-1111.
19. Jeanneton, O., Delvaux, M., Botella, A., Frexinos, J. & Buéno, L. (1993) Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. Journal of Pharmacology and Experimental Therapeutics, 267, 31-37.
20. Jeanneton, O., Delvaux, M., Langlois, Y., LeBars, P., LeBars, J., Delisle, M.B., Frexinos, J. & Buéno, L. (1998) Correlation of desensitisation of platelet activating factor (PAF) receptors with intensity of inflammation and intestinal PAF content during experimental ileitis in guinea pig. Gut, 43, 356-364.
21. Jouët, P. & Sarna, S.K. (1996) Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation. Journal of Pharmacology and Experimental Therapeutics, 279, 207-213.
22. Kamata, K., Arai, Y. & Kasuya, Y. (1993) Mechanism of the contractile response to platelet-activating factor (PAF) of the rat stomach fundus. I. PAF-induced contractile response and calcium mobilization. General Pharmacology, 24, 1331-1336.
23. King, J.N. & Gerring, E.L. (1990) Antagonism of endotoxin-induced disruption of equine gastrointestinal motilily with the platelet-activating factor antagonist. WEB 2086. Journal of Veterinary Pharmacology and Therapeutics, 13, 333-339.
24. Koltai, M. & Braquet, P.G. (1994) Platelet-activating factor antagonists. Clinical Reviews in Allergy, 12, 361-380.
25. Kruse-Elliott, K.T., Albert, D.H., Summers, J.B., Carter, G.W., Zimmerman, J.J. & Grossman, J.E. (1996) Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. Shock, 5, 265-273.
26. Longo, W.E., Carter, J.R. Chandel, B., Niehoff, M., Slandeven, J., Deshpande, Y., Vernava, A.M., Polites, G., Kulkarni, A.D. & Kaminski, D.L. (1995) Evidence for a colonic PAF receptor. Journal of Surgical Research, 58, 12-18.
27. Million, M., Floramonti, J., Zajac, J.M. & Buéno, L. (1997) Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. European Journal of Pharmacology. 334, 67-73.
28. Mozes, T., Ben-Efraim, S. & Bonta, I.L. (1992) Lethal and non-lethal course of endotoxic shock is determined by interactions between tumor necrosis factor, platelet activating factor and cicosanoids. Pathologie Biologie, 40, 807-812.
29. Olson, N.C. (1990) SRI 63-675 and indomethacin modify porcine cardiopulmonary responses to platelet-activating factor. In Platelet-Activating Factor in Endotoxin and Immune Diseases. Eds Handley, D.A., Saunders, R.N., Houlihan, W.J. & Tomesch, J.C. pp. 131-156. Marcel Dekker, New York.
30. Olson, N.C., Dodam, J.R. & Kruse-Elliott, K.T. (1992) Endotoxemia and gram-negative bacteremia in swine: chemical mediators and therapeutic considerations. Journal of the American Veterinary Medical Association, 200, 1884-1893.
31. Olson, N.C., Hellyer, P.W. & Dodam, J.R. (1995) Mediators and vascular effects in response to endotoxin. British Veterinary Journal, 151, 489-522.
32. Pons, L., Droy-Lefaix, M.T., Braquet, P. & Buéno, L. (1991a) Role of free radicals and platelet-activating factor in the genesis of intestinal motor disturbances induced by Escherichia coli endotoxins in rats. Gastroenterology, 100, 946-953.
33. Pons, L., Droy-Lefaix, M.T., Braquet, P. & Buéno, L. (1991b) Myoelectric intestinal disturbances in Escherichia coli endotoxic shock in rats. Involvement of platelet-activating factor. Lipids, 26, 1359-1161.
34. Pons, L. Droy-Lefaix, M.T. & Buéno, L. (1994) Role of platelet-activating factor and proslaglandins in colonic motor and secretory disturbances induced by Escherichia coli endotoxin in conscious rats. Prostaglandins, 47, 123-136.
35. Qu, X., Huang, L., Burthart, T., Crawford, S.E., Caplan, M.S. & Hsueh, W. (1996) Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. Prostaglandins, 51, 249-262.
36. Sánchez Crespo, M.S. & Fernandez-Gallardo, S. (1991) Pharmacological modulation of PAF: a therapeutic approach to endotoxin shock. Journal of Lipid Mediators and Cell Signalling, 4, 127-144.
37. Siebeck, M., Kohl, J., Endres, S., Spannagl, M. & Machleidt, W. (1994) Delayed treatment with platelet activating factor receptor antagonist WEB 2086 attenuates pulmonary dysfunction in porcine endotoxin shock. Journal of Trauma, 37, 745-751.
38. Wechsung, E., De Saedeleer, V. & Houvenaghel, A. (1989) Some characteristics of the small intestinal migrating myoelectric complex in the piglet. Archives Internationales de Physiologie et de Biochimie. 97, P83-P84.
39. 4 on arterial pressure and gastrointestinal electrical activity in the conscious piglet. Prostaglandins Leukotrienes and Essential Fatty Acids, 46, 27-31.
40. Yoshikawa, D., Shiga, T., Saito, S., Morita, T., Imai, T. & Goto, F. (1998) Platelet-activating factor receptor antagonist attenuates endotoxin-induced vascular hyporeactivity in the pithed rat. European Journal of Pharmacology, 342, 241-245.