Quantitative gas chromatographic/mass spectroscopic determination of the pentaerithrityltetranitrate metabolites pentaerithrityltrinitrate, pentaerithrityldinitrate and pentaerithritylmononitrate in human plasma;Quantitative gaschromatographische/massenspektrometrische bestimmung der pentaerithrityltetranitrat-metaboliten pentaerithrityltrinitrat, pentaerithrityldinitrat und pentaerithritylmononitrat in humanplasma

Arzneimittel-Forschung/Drug Research

Volumn 49, Issue 11, 1999, Pages 891-895

  Schuätz, Andrea ^a   Kötting, Jochem ^b   Epple, Franz ^b   Ziegler, Ronald ^c   Maier Lenz, Herbert ^c   Stalleicken, Dirk ^a  

^a ISIS Pharma GmbH   (Germany)

^b Klinischen Pharmakol MBH   (Germany)

^c ALBSTADT SIGMARINGEN UNIVERSITY   (Germany)

Author keywords

CAS 1607 00 7; CAS 1607 01 8; CAS 1607 17 6; CAS 78 11 5; Pentaerithrityltrinitrate, assay methods, metabolites; Pentalong

Indexed keywords

NITRIC ACID DERIVATIVE; PENTAERYTHRITYL TETRANITRATE; DRUG DERIVATIVE; ERYTHRITOL; PENTAERYTHRITOL DINITRATE; PENTAERYTHRITOL MONONITRATE; PENTRINITROL; VASODILATOR AGENT;

ACCURACY; ARTICLE; DRUG DETERMINATION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; SPECTRAL SENSITIVITY; BIOTRANSFORMATION; BLOOD; CALIBRATION; HUMAN; MASS FRAGMENTOGRAPHY;

BIOTRANSFORMATION; CALIBRATION; ERYTHRITOL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PENTAERYTHRITOL TETRANITRATE; VASODILATOR AGENTS;

EID: 0032750917     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300522     Document Type: Article

References (6)

1. Commarato, M. A., Winberg, M. M., Kaplan, 11. R., Glyceryl trinitrate and pentrinitrol (pentaerytritoltrinirate): Comparative cardiovascular effects in dog, cat and rat by different routes of administration. J. Pharmacol. Exp. Ther 187, 300 (1973)
2. Hinz, B., Kuntze, U., Schr̈der, II., Pentaerythrityl tetranitrate and its phase I metabolites are potent activators of cellular cyclic GMP accumulation. Biochem. Biophys. Res. Commun. 253, 658 (1998)
3. Kojda, G., Hacker, A., Noack F., Effects of non-intermittent treatment of rabbits with pentaerythritol tetranitrate on vascular reactivity and superoxide production. Eur. J. Pharmacol. 355, 23 (1998)
4. Luckow, V., Michaelis, K., Hiebl, R., Pharmakokineik und bioverfügbarkeit von pentaerithrityltetranitrat und seinen metaboliten. In: Pentaerithrityltetranitrat Beiträge zum zum Klinischen und Pharmakologischen Status. H. T. Schneider, D. Stalleicken (Hrsg.), Steinkopff Verag, Darmstadt (1995)
5. Parker, J. C., Chang Y.-C., Davidson I. W. E F, Coronary vasodilator activity of pentaerythritol trinitrate and its metabolites assayed in the dog. Fed. Proc. 32, 794 (1973)
6. Stalleicken, D., Kuntze, U., Schmid, B. et al., Quantitative determination of pentaerythrityl tetranitrate and its metabolites in human plasma by gas chromatography/mass spectrometry. Arzneim. Forsch./Drug Res. 47 (I), 347 (1997)