Quantitative determination of pentaerythrityl tetranitrate and its metabolites in human plasma by gas chromatography/mass spectrometry

Arzneimittel-Forschung/Drug Research

Volumn 47, Issue 4, 1997, Pages 347-352

  Stalleicken, Dirk ^a   Kuntze, Ulrike ^a   Schmid, Bernhard ^b   Hiebl, Rosemarie ^b   Ring, Jürgen ^b   Michaelis, Karl ^b,c  

^a ISIS Pharma GmbH   (Germany)

^b LAB Gesell F Pharmakologische U   (Germany)

^c LAB GmbH and Co   (Germany)

Author keywords

CAS 78 11 5; pentaerythrityl tetranitrate, metabolites, quantitative determination in plasma

Indexed keywords

DRUG METABOLITE; ISOSORBIDE DINITRATE; PENTAERYTHRITYL TETRANITRATE;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; QUANTITATIVE ASSAY; TECHNIQUE;

CALIBRATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PENTAERYTHRITOL TETRANITRATE; VASODILATOR AGENTS;

EID: 0030981249     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bjerlöv, H., Svenska Läk. Tidn. 40, 649 (1943)
2. Maier-Lenz, H., Dück, K.-D., in: H. T. Schneider (ed.), Pentaerythrityltetranitrat, Darmstadt (1995)
3. Laufen, H., Scharpf, F., Bartsch, G., J. Chromatogr. 146, 457 (1978)
4. Doyle, E., Chasseaud, L. F., Tayler, T., Biopharm. Drug Dispos. 1, 141 (1980)
5. Miyazaki, H., Ishibashi, M., Hashimoto, Y. et al., J. Chromatogr. 239, 277 (1982)
6. Ottoila, P., Taskinen, J., Sothmann, A., Biomed. Mass Spectrom. 9, 108 (1982)
7. Settlage, J. A., Gielsdorf, W., Jaeger, H., J. High Resol. Chromatogr. Chrom. Commun. 6, 68 (1983)
8. Kühn, R., Luckow, V., Keppeler, D., Z. Analyt. Chem. 317, 668 (1984)
9. Neurath, G. B., Dünger, M., Arzneim.-Forsch./Drug Res. 27 (I), 426 (1977)
10. Gilbert, J. D., Aylott, R. I., Draffan, G. H. et al., Arzneim.-Forsch./Drug Res. 32 (II), 1138 (1982)
11. Pristera, F., Halik, M., Castelli, A. et al., Anal. Chem. 32, 495 (1960)
12. Whitnak, G. C., Mayfield, M. M., Gant, E. S. C., Anal. Chem. 37, 899 (1965)
13. Di Carlo, F. J., Crew, M. C., Sklow, N. J. et al., J. Pharmacol. Exp. Ther. 153, 254 (1976)
14. Di Carlo, F. J., Crew, M. C., Haynes, L. J. et al., Biochem. Pharmacol. 17, 2178 (1968)
15. Reed, D. E., Akester, J. M., Prather, J. F. et al., J. Pharmacol. Exp. Ther. 202, 32 (1977)
16. Crew, M. C., Gala, R. L., Hayes, L. J. et al., J. Biochem. Pharmacol. 20, 3077 (1971)
17. Crew, M. C., Melgar, M. D., Di Carlo, F. J. , J. Pharmacol. Exp. Ther. 192, 1975 (218)
18. Roseel, M. T., Bogaert, M. G., J. Chromatogr. 64, 364 (1974)
19. Davidson, I. W. F., Di Carlo, F. J., J. Chromatogr. 57, 345 (1971)
20. Assinder, D. F., Chasseaud, L. F., Taylor, T., J. Pharm. Sci. 66, 775 (1977)
21. Yap, P. S. K., McNiff, E. F., Fung, H. L., J. Pharm. Sci. 67, 583 (1978)
22. Armstrong, J. A., Marks, G. S., Armstrong, P. W., Mol. Pharmacol. 18, 112 (1980)
23. Chandler, C. D., Gibson, G. R., Bolleter, W. T., J. Chromatogr. 100, 185 (1974)
24. Chin, D. A., Prue, D. G., Michelucci, J. et al., J. Pharm. Sci. 66, 1143 (1977)
25. Crouthamel, W. G., Dorsch, B., J. Pharm. Sci. 68, 481 (1979)
26. Yu, W. C., Goff, E. U., Anal. Chem. 55, 29 (1983)
27. Di Carlo, F. J., Hartigan, J. M., Coutinho, C. B. et al., Proc. Soc. Exp. Biol. Med. 118, 311 (1965)
28. Crew, M. C., Coutinho, C. B., DiCarlo, F. J., J. Pharm. Sci. 55, 1137 (1966)
29. King, S. Y. P., Fung, H. L., Drug Metab. Disp. 12, 353 (1984)
30. Crew, M. C., Melgar, M. D., DiCarlo, F. J., J. Pharmacol. Exp. Ther. 192, 218 (1975)
31. Davidson, I. W. F., Miller, H. S., DiCarlo, F. J., J. Pharm. Sci. 60, 274 (1971)
32. Weber, W., Michaelis, K., Luckow, V. et al., Arzneim.-Forsch./Drug Res. 45 (II), 781 (1995)