Inhibition of pneumococcal topoisomerases by sitafloxacin

Drugs

Volumn 58, Issue SUPPL. 2, 1999, Pages 354-355

  Morrissey, I ^a   George, J T ^a  

^a GR Micro Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CIPROFLOXACIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; LEVOFLOXACIN; OFLOXACIN; SITAFLOXACIN; SPARFLOXACIN;

BACTERIAL GENE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; MOLECULAR CLONING; NONHUMAN; STREPTOCOCCUS PNEUMONIAE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

EID: 0032750512     PISSN: 00126667     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003495-199958002-00120     Document Type: Conference Paper

References (11)

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2. 2. AB Khodursky EL Zechiedrich NR Cozzarelli 1995 Topoisomerase IV is a target of quinolones in Escherichia coli. Proc Natl Acad Sci USA 92 11801 5 8524852 10.1073/pnas.92.25.11801 1:CAS:528:DyaK2MXpvVOnt74%3D Khodursky AB, Zechiedrich EL, Cozzarelli NR. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc Natl Acad Sci USA 1995; 92: 11801–5
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5. 5. X-S Pan LM Fisher 1996 Cloning and characterisation of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV; role in fluoroquinolone resistance J Bacteriol 178 4060 9 8763932 1:CAS:528:DyaK28Xktlyitr0%3D Pan X-S, Fisher LM. Cloning and characterisation of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV; role in fluoroquinolone resistance. J Bacteriol 1996; 178: 4060–9
6. 6. TD Gootz R Zaniewski S Haskell 1996 Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro Antimicrob Agents Chemother 40 2691 7 9124824 1:CAS:528:DyaK28Xnt1CmtbY%3D Gootz TD, Zaniewski R, Haskell S, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother 1996; 40: 2691–7
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