A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region of the rat proteinase α1-inhibitor 3 variant I gene

Biological Chemistry

Volumn 380, Issue 10, 1999, Pages 1217-1223

  Sickinger, Stefan ^a,b   Schweizer, Michael ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

1 inhibitor 3; Acute phase protein; Polypyrimidine tract binding protein

Indexed keywords

ACUTE PHASE PROTEIN; ALPHA1 PROTEINASE INHIBITOR III; BINDING PROTEIN; COMPLEMENTARY DNA; GLUTATHIONE TRANSFERASE; MESSENGER RNA; PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; CODON; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; RAT;

5' UNTRANSLATED REGIONS; ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; MOLECULAR SEQUENCE DATA; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROMOTER REGIONS (GENETICS); RATS; RECOMBINANT FUSION PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA-BINDING PROTEINS; TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EUKARYOTA; RODENTIA;

EID: 0032749842     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.154     Document Type: Article

References (29)

1. 1-Inhibitor III gene. Mol. Biol. Med. 7, 261-271.
2. Baumann, H., Onorato, V., Gauldie, J., and Jahreis, G.P. (1987). Distinct sets of acute-phase plasma proteins are stimulated by separate human hepatocyte stimulating factors and monokines in rat hepatoma cells. J. Biol. Chem. 262, 9756-9768.
3. Baumann, H., Prowse, K.R., Marinkovic, S., Won, K.A., and Jahreis, G.P. (1989). Stimulation of hepatic acute-phase response by cytokines and glucocorticoids. Ann. N.Y. Acad. Sci. 557, 280-296.
4. 2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J. 6, 3345-3353.
5. Boshart, M., Klüppel, M., Schmidt, A., Schütz, G., and Luckow, B. (1992). Reporter constructs with low background utilizing the cat gene. Gene 110, 129-130.
6. 1-Inhibitor III messenger RNA. J. Biol. Chem. 263, 3999-4012.
7. Brahmachari, S.K., Sarkar, P.S., Raghavan, S., Narayan, M., Maiti, A.K. (1997). Polypurine/polypyrimidine sequences as cis-acting transcriptional regulators. Gene 190, 17-26.
8. Brunel, F., Alzari, P.M., Ferrara, P., and Zakin, M.M. (1991). Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein. Nucl. Acids Res. 19, 5237-5245.
9. Brunel, F., Zakin, M.M., Buc, H., and Buckle, M. (1996). The polypyrimidine tract binding (PTB) protein interacts with single-stranded DNA in a sequence specific manner. Nucl. Acids Res. 24, 1608-1615.
10. Devereux, J., Haeberli, P., and Smithies, O. (1984). A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids Res. 12, 387-395.
11. 1-Inhibitor III: A member of the α-macroglobulin family. FEBS Lett. 182, 125-129.
12. Faisst, S., and Meyer, S. (1992). Compilation of vertebrate-encoded transcription factors. Nucl. Acids Res. 20, 3-26.
13. Gil, A., Sharp, P.A., Jamison, S.F., and Garcia-Blanco, M.A. (1991). Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes Dev. 5, 1224-1236.
14. Gorman, C.M., Moffat, L.F., and Howard, B.H. (1982). Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051.
15. Grange, T., Roux, J., Rigaud, G., and Pictet, R. (1990). Cell-type specific activity of two glucocorticoid response units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucl. Acids Res. 19, 131-139.
16. Guan, K.L., and Dixon, J.E. (1991). Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem. 192, 262-267.
17. 2-macroglobulin. Methods Enzymol. 45, 639-652.
18. 2(I) collagen gene. J. Biol. Chem. 271, 26717-26723.
19. Jansen-Dürr, P., Boshart, M., Lupp, B., Bosserhoff, A., Frank, R.W., and Schütz, G. (1992). The rat poly pyrimidine tract binding protein (PTB) interacts with a single-stranded DNA motif in a liver-specific enhancer. Nucl. Acids Res. 20, 1243-1249.
20. Lonberg-Holm, K., Reed, D.L., Roberts, R.C., Hebert, R.R., and Hillman, M.C. (1987). Three high molecular weight proteinase inhibitors in rat plasma. J. Biol. Chem. 262, 438-445.
21. Ochoa, A., Brunel, F., Mendelzon, D., Cohen, G.N., and Zakin, M.M. (1989). Different liver nuclear proteins binds to similar DNA sequences in the 5′ flanking regions of three hepatic genes. Nucl. Acids Res. 17, 119-133.
22. Patton, J., Mayer, S.A., Tempst, P., and Nadal-Ginard, B. (1991). Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev. 5, 1237-1251.
23. Ray, A., and Ray, B.K. (1996). A novel cis-acting element is essential for cytokine-mediated transcriptional induction of the serum amyloid A gene in nonhepatic cells. Mol. Cell. Biol. 16, 1584-1594.
24. 1-inhibitor 3. FEBS Lett. 282, 368-372.
25. 1-inhibitor 3. Eur. J. Biochem. 164, 375-381.
26. Seed, B., and Sheen, J.Y. (1988). A simple phase-extraction assay for chloramphenicol acetyltransferase activity. Gene 67, 271-277.
27. 2-M) that can react rapidly to incorporate not only methylamine or putrescine but also proteins lacking proteinase activity. FEBS Lett. 128, 123-126.
28. 2-macroglobulin and related thiol ester plasma proteins. In: The Plasma Proteins, 2nd ed., Volume V, F.W. Putnam, ed., (Orlando, USA: Academic Press, Inc.), pp. 191-291.
29. Sottrup-Jensen, L., Sand, O., Kristensen, L., and Fey, G.H. (1989). The α-macroglobulin bait-region. Sequence diversity and localisation of cleavage sites for proteinases in five mammalian α-macroglobulins. J. Biol. Chem. 264, 15781-15789.