Antibodies from systemic lupus erythematosus (SLE) sera define differential release of autoantigens from cell lines undergoing apoptosis

Clinical and Experimental Immunology

Volumn 118, Issue 2, 1999, Pages 322-328

  Huggins, Mary L ^a,b   Todd, I ^a   Cavers, M A ^a   Pavuluri, S R ^a   Tighe, P J ^a   Powell, R J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Apoptosis; Histones; Systemic lupus erythematosus

Indexed keywords

AUTOANTIGEN; HISTONE; HISTONE ANTIBODY;

ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; APOPTOSIS; ARTICLE; CELL LINE; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; BLOTTING, WESTERN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HISTONES; HUMANS; IMMUNOGLOBULIN G; JURKAT CELLS; LUPUS ERYTHEMATOSUS, SYSTEMIC; SODIUM DODECYL SULFATE; TUMOR CELLS, CULTURED; U937 CELLS;

EID: 0032747631     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01063.x     Document Type: Article

References (25)

1. 1 Stollar B. The antigenic potential and specificity of nucleic acids, nucleoproteins, and their modified derivatives. Arthritis Rheum 1981; 28:1010-7.
2. 2 Casciola-Rosen L, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179:1317-30.
3. 3 Casciola-Rosen L, Miller D, Anhalt G et al. Specific cleavage of the 70kDa protein component of the U1-small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem 1994; 269:30757-60.
4. 4 Casciola-Rosen L, Anhalt G, Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med 1995; 182:1625-34.
5. 5 Casiano C, Martin S, Green D et al. Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis. J Exp Med 1996; 184:765-70.
6. 6 Enari M, Sakahira H, Yokoyama H et al. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391:43-50.
7. 7 Stemmer C, Muller S. Histone autoantibodies other than (H2A-H2B)-DNA autoantibodies. In: Peter J, Shoenfeld Y, eds. Autoantibodies. Amsterdam: Elsevier Science B. V., 1996:373-84.
8. 8 Fritzler M. Antibodies to histone and the role of the nucleosome. In: Wallace DJ, Hahn BH, eds. Dubois' lupus erythematosus. Baltimore: Williams & Wilkins, 1997:423-41.
9. 9 Rubin R. Histone (H2A-H2B)-DNA autoantibodies. In: Peter J, Shoenfeld Y, eds. Autoantibodies. Amsterdam: Elsevier Science BV, 1996:364-71.
10. 10 Desai-Mehta A, Mao C, Rajagopalan S et al. Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J Clin Invest 1995; 95:531-41.
11. 11 Voll R, Roth E, Girkontaite I et al. Histone-specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double-stranded DNA antibody production. Arthritis Rheum 1997; 40:2162-71.
12. 12 Cabrespines A, Laderach D, Lebosse C et al. Isolation and characterization of apoptotic nucleosomes, free and complexed with lupus autoantibody generated during hybridoma B cell apoptosis. J Autoimmun 1998; 11:19-27.
13. 13 Amoura Z, Piette J, Chabre H et al. Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus - correlation with serum antinucleosome antibody titers and absence of clear association with disease activity. Arthritis Rheum 1997; 40:2217-25.
14. 14 Subiza JL, Caturla A, Pascual-Salcedo D et al. DNA-anti-DNA complexes account for part of the anti-histone activity found in patients with systemic lupus erythematosus. Arthritis Rheum 1989; 32:406-11.
15. 15 Zubler PH, Perrin LH, Greighton WD. Use of polyethylene glycol (PEG) to concentrate immune complexes from serum or plasma samples. Ann Rheum Dis 1977; 36:23-25.
16. 16 Amoura Z, Piette J-C, Bach J-F et al. The key role of nucleosomes in lupus. Arthritis Rheum 1999; 42:833-43.
17. 17 Bustos A, Boimorto R, Subiza J et al. Inhibition of histone/anti-histone reactivity by histone binding serum components; differential effect on anti-H1 versus anti-H2B antibodies. Clin Exp Immunol 1994; 95:408-14.
18. 18 O'Dell JR, Bizar-Schneebaum A, Kotzin BL. In vitro anti-histone antibody production by peripheral blood cells from patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1988; 47:343-53.
19. 19 Kohda S, Kanayam Y, Okamura M et al. Clinical significance of antibodies to histones in systemic lupus erythematosus. J Rheumatol 1989; 16:24-28.
20. 20 Andrade F, Roy S, Nicholson D et al. Granzyme-B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 1998; 8:451-60.
21. 21 Treves S, Bajocchi G, Zorzato F et al. Identification and characterization of a calreticulin-binding nuclear protein as histone (H1), an autoantigen in systemic lupus erythematosus. Lupus 1998; 7:479-87.
22. 22 Ren Y, Savill J. Apoptosis: the importance of being eaten. Cell Death Diff 1998; 5:563-8.
23. 23 Herrmann M, Voll R, Zoller D et al. Impaired phagocytosis apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41:1241-50.
24. 5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 1998; 7:1359-68.
25. 25 Casciola-Rosen L, Rosen A. Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 1997; 6:175-80.