Cooling the asphyxiated brain - Ready for clinical trials?

European Journal of Pediatrics, Supplement

Volumn 158, Issue 1, 1999, Pages

  Thoresen, M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Brain; Hypothermia; Hypoxia ischaemia; Neuroprotection; Newborn

Indexed keywords

ASPHYXIA; BRAIN INJURY; CONTROLLED STUDY; COOLING; HYPOTHERMIA; HYPOXIA; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA NEONATORUM; DISEASE MODELS, ANIMAL; HUMANS; HYPOTHERMIA; HYPOXIA, BRAIN; INFANT, NEWBORN; NEUROPROTECTIVE AGENTS; RATS; SHEEP;

EID: 0032747248     PISSN: 09439676     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (27)

1. Amess PN, Penrice J, Lorek A, Kirkbride V, Cooper CE, Wylezinska M, D'Souza P, Cady ED, Thoresen M, Edwards AD, Wyatt JS, Reynolds EOR (1997) Mild hypothermia after severe transient hypoxia-ischemia reduces the delayed rise in cerebral lactate in the piglet. Pediatr Res 41:803-808
2. Bona E, Løberg EM, Bågenholm R, Hagberg H, Thoresen M (1998) Protective effects of moderate hypothermia after hypoxia-ischemia in a neonatal rat model: short and long-term outcome. Pediatr Res 43:738-745
3. Burnard ED, Cross KW (1958) Rectal temperature in the newborn after birth asphyxia. Br Med J 11:1197-1199
4. Coimbra C, Drake M, Borismoller F, Wieloch T (1996) Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug - evidence for chronic encephalopathic processes following ischemia. Stroke 27:1578-1585
5. Edwards AD, Yue X, Squier MV, Thoresen M, Cady E, Penrice J, Cooper C, Wyatt JS, Reynolds EOR, Mehmet H (1995) Specific inhibition of apoptosis after cerebral hypoxia-ischemia by moderate post-insult hypothermia. Biochem Biophys Res Comm 217:1193-1199
6. Gordon C, Fogelson L (1991) Comparative effects of hypoxia on behavioral thermoregulation in rats, hamsters and mice. Am J Physiol 260:R120-R125
7. Gunn AJ, Gunn TR, deHaan HH, Williams CE, Gluckman PD (1997) Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest 99:248-256
8. Gunn AJ, Gluckman PD, Gunn TR (1998) Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 102:885-892
9. Haaland K, Løberg EM, Steen PA, Thoresen M (1997) Post-hypoxic hypothermia in newborn piglets. Pediatr Res 41:505-512
10. Haaland K, Løberg EM, Steen PA, Satas S, Thoresen M (1997) The effect of mild posthypoxic hypothermia on organ pathology in a piglet survival model of global hypoxia. Prenat Neonat Med 2:329-337
11. Marion DWea (1997) Treatment of traumatic brain injury with moderate hypothermia. New Eng J Med 336:540-546
12. McQuinston WO (1949) Anesthetic problems in cardiac surgery in children. Anesthesiology 10:590-600
13. Miller JA (1949) Factors in neonatal resistance to anoxia. I. Temperature and survival of newborn guinea pigs under anoxia. Science 110:113-114
14. Miller JA, Miller FS (1962) Factors in neonatal resistance to anoxia. Am J Obst Gyn 84:44-56
15. Reith J, Jørgensen HS, Pedersen PM, Nakayama H, Raaschou HO, Jeppesen LL, Olsen TS (1996) Body temperature in acute stroke: relation to stroke severity, infarct size, mortality and outcome. The Lancet 347:422-425
16. Roth SC, Baudin J, Cady E, et al (1997) Relation of deranged neonatal cerebral oxidative metabolism with neurodevelopmental outcome and head circumference at 4 years. Dev Med Child Neurol 39:718-725
17. Silverman WA, Fertig JW, Berger AP (1958) The influence of the thermal environment upon the survival of newly born premature infants. Pediatrics 22:876-886
18. Sirimanne ES, Blumberg RM, Bossano D, Gunnong M, Edwards AD, Gluckman PD, Williams CE (1996) The effect of prolonged modification of cerebral temperature on the outcome after hypoxic-ischaemic brain injury in the infant rat. Pediatr Res 39:591-597
19. Thoresen M, Apricena F, Løberg EM, Bågenholm R, Bona E, Hagberg H, Kjellmer I (1998) Post-hypoxic-ischemic (H-1) hypothermia (HT) reduces necrosis and apoptosis correspondingly in the newborn rat however restraint stress ameliorates neuroprotection. Pediatr Res 44:421A
20. Thoresen M, Bågenholm R, Løberg EM, Apricena F, Kjellmer I (1996a) Posthypoxic cooling of neonatal rats provides protection against brain injury. Arch Dis Child 74:F3-F9
21. Thoresen M, Haaland K, Løberg EM, Apricena F, Hankø E, Whitelaw A, Steen PA (1996b) A piglet survival model for posthypoxic encephalopathy. Pediatr Res 40:738-748
22. Thoresen M, Penrice J, Lorek A, Wyatt J, Cady EB, Wylezinska M, Kirkbridge V, Cooper C, Edwards D, Brown G, Reynolds EOR (1995) Mild hypothermia following severe transient hypoxia-ischemia ameliorates delayed ('secondary') cerebral energy failure in the newborn piglet. Pediatr Res 5:667-670
23. Thoresen M, Satas S. Hallstrøm Å, Whitelaw A, Puka-Sundvall M, Løberg E, Steen PA, Ungestedt U, Hagberg H (1997) Posthypoxic hypothermia in newborn pigs: effect on excitatory aminoacids and the citrulline/arginine ratio. NeuroReport 8:3359-3362
24. Trescher WH, Ishiwa S, Johnston MV (1997) Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury. Brain Dev 19:326-338
25. Westin B, Miller JA, Nyberg R, Wedenberg E (1959) Neonatal asphyxia pallida treated with hypothermia alone or with hypothermia and transfusion of oxygenated blood. Surgery 45:868-879
26. Williams GR, Spencer FC (1958) The clinical use of hypothermia following cardiac arrest. Ann Surg 148:462-466
27. Yager J, Towfighi J, Vannucci RC (1993) Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat. Ped Res 34:525-529