Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 5, 1999, Pages 585-590

  Hattori, Yuichi ^a   Ishitani, Toshiteru ^a   Tomita, Fumishi ^a   Gando, Satoshi ^a   Yokoshiki, Hisashi ^a   Azuma, Mitsue ^a   Kemmotsu, Osamu ^a   Kanno, Morio ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Action potentials; Ca2+ sensitizing action; Cardiac muscle; Chronotropic action; Delayed rectifier; EGIS 9377; Inotropic action; Potassium current

Indexed keywords

2 (1 METHYLTHIO) 5 (2 MORPHOLINOETHYLAMINO) 8,9 DINHYDRO 7H THIOPYRANO[3,2 D][1,2,4]TRIAZOLO[1,5 A]PYRIMIDINE; 4,5 DIHYDRO 6 [4 (4 PYRIDYLAMINO)PHENYL] 3(2H) PYRIDAZINONE; 5 [1 (3,4 DIMETHOXYBENZOYL) 1,2,3,4 TETRAHYDRO 6 QUINOLYL] 3,6 DIHYDRO 6 METHYL 2H 1,3,4 THIADIAZIN 2 ONE; CALCIUM ION; CARDIOTONIC AGENT; ISOPRENALINE; N HYDROXY 5,6 DIMETHOXY 2 BENZO[B]THIOPHENECARBOXIMIDAMIDE; PIMOBENDAN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; FEMALE; GUINEA PIG; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HEART MUSCLE RELAXATION; INOTROPISM; MALE; NONHUMAN; POTASSIUM CURRENT;

ANIMALS; CALCIUM; CARDIOTONIC AGENTS; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; FEMALE; GUINEA PIGS; HEART; HEART RATE; HEART VENTRICLES; ISOPROTERENOL; MALE; MORPHOLINES; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PYRIDAZINES; PYRIMIDINES; TIME FACTORS;

EID: 0032746866     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900127     Document Type: Article

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