Comparison of the effect of FK506 and cyclosporin A on virus production in H9 cells chronically and newly infected by HIV-1

Archives of Virology

Volumn 144, Issue 11, 1999, Pages 2151-2160

  Briggs, C J ^a   Ott, D E ^b   Coren, L V ^b   Oroszlan, S ^a   Tozser J ^a,c  

^a ABL Basic Research Program   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN 12; CYCLOPHILIN A; CYCLOSPORIN A; DRUG RESISTANCE; GAG PROCESS; HUMAN IMMUNODEFICIENCY VIRUS 1; PEPTIDYL PROLYL CIS TRANS ISOMERASE; VIRUS DETECTION; VIRUS INFECTIVITY; VIRUS REPLICATION;

ANTI-HIV AGENTS; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HIV CORE PROTEIN P24; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; IMMUNOPHILINS; TACROLIMUS; TACROLIMUS BINDING PROTEINS; TUMOR CELLS, CULTURED;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032745710     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007050050629     Document Type: Article

References (25)

1. 1. Aberham C, Weber S, Phares W (1996) Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins. J Virol 70: 3536-3544
2. 2. Billich A, Hammerschmid F, Peichl P, Wenger R, Zenke G, Quesniaux V, Rosenwirth B (1995) Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions. J Virol 69: 2451-2461
3. 3. Braaten D, Aberham C, Franke EK, Yin L, Phares W, Luban J (1996) Cyclosproine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A. J Virol 70: 5170-5176
4. 4. Braaten D, Franke EK, Luban J (1996) Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before initiation of reverse transcription. J Virol 70: 3551-3560
5. 5. Briggs CJ, Tözsér J Oroszlan S (1996) Effect of cyclosporin A on the replication cycle of HIV-1 derived replication cycle of HIV-1 derived from H9 and Molt-4 producer cells. J Gen Virol 77: 2963-2967
6. 6. DeLuca C, Roulston A, Koromilas A, Wainberg MA, Hiscott J (1996) Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-κB/Rel pathway via enhanced iκBα degradation. J Virol 70: 5183-5193
7. 7. Franke KE, Yuan HEH, Luban J (1994) Specific incorporation of cyclophilin A into HIV-1 virons. Nature 372: 359-362
8. 8. Fruman DA, Burakoff SJ, Bierer BE (1994) Immunophilins in protein folding and immunosuppression. FASEB J 8: 391-400
9. 9. Gupta S, Vayuvegula B (1987) Human immunodeficiency virus-associated changes in signal transduction. J Clin Immunol 7: 486-489
10. 10. Harrison RK, Stein RL (1990) Substrate specificities of the peptidyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein. Evidence for the existence of a family of distinct enzymes. Biochemistry 29: 3813-3816
11. 11. Karpas A, Lowdell M, Jacobson SK, Hill F (1992) Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK506. Proc Natl Acad Sci USA 89: 8351-8355
12. 12. Kimpton J, Emerman M (1992) Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated β galactosidase gene. J Virol 66: 2232-2239
13. 13. Luban J, Bossolt KL, Franke EK, Kaplana GV, Goff SP (1993) Human immunodeficiency virus type 1 gag protein binds to cyclophilins A and B. Cell 73: 1067-1068
14. 14. MacArthur WM, Thornton JM (1990) Influence of proline residues on protein conformation. J Mol Biol 218: 397-412
15. 15. McCornack MA, Kakalis LT, Castera C, Handschumacher RE, Armitage IM (1997) HIV protease substrate conformation: modulation by cyclophilin A. FEBS Lett 414: 84-88
16. 16. Nagy K, Young M, Baboonian C, Merson J, Whittle P, Oroszlan S (1994) Antiviral activity of human immunodeficiency virus type 1 protease inhibitors in a single cycle of infection: evidence for a role of protease in the early phase. J Virol 68: 757-765
17. 17. Nye KE, Pinching AJ (1990) HIV infection of H9 lymphoblastoid cells chronically activates the inositol polyphosphate pathway. AIDS 4: 41-45
18. 18. Oroszlan S, Tözsér J (1990) The retroviral proteinase. Semin Virol 1: 369-378
19. 19. Ott DE, Coren LV, Johnson DG, Sowder RCII, Arthur LO, Henderson LE (1995) Analysis and localization of cyclophilin A found in the virions of human immunodeficiency virus type 1 MN strain. AIDS Res Hum Retroviruses 11: 1003-1006
20. 20. Ott DE (1997) Cellular proteins in HIV-1 virions. Rev Med Virol 7: 167-180
21. 21. Popovic MM, Sarngadharan G, Read E, Gallo RC (1984) Detection, isolation, and continous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224: 497-500
22. 22. Rosenwirth B, Billich A, Datema R, Donatsch P, Hammerschmid F, Harrison R, Hiestand P, Jaksche H, Mayer P, Peichl P, Quesniaux V, Schatz F, Schuurman H-J, Traber R, Wenger R, Wolff B, Zenke G, Zurini M (1994) Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog. Antimicrob Agents Chemother 38: 1763-1772
23. 23. Thali M, Bukovsky A, Kondo E, Rosenwirth B, Walsh CT, Sodroski J, Göttlinger HG (1994) Functional association of cyclophilin A with HIV virion. Nature 372: 363-365
24. 3' subsites of HIV-1 proteinases. Biochemistry 31: 4793-4800
25. 25. Vance Je, LeBlance DA, Wingfield P, London RE (1997) Conformational selectivity of HIV-1 protease cleavage of X-Pro peptide bonds and its implications. J Biol Chem 272: 15603-15606