Novel antimigraineur dotarizine releases Ca2+ from caffeine-sensitive Ca2+ stores of chromaffin cells

British Journal of Pharmacology

Volumn 128, Issue 3, 1999, Pages 621-626

  Novalbos, Jesús ^a,b   Abad Santos, Francisco ^a,b   Zapater, Pedro ^a,b   Alvarez, Javier ^c   Alonso, María Teresa ^c   Montero, Mayte ^c   García, Antonio G ^a,b,d  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^c UNIVERSITY OF VALLADOLID   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Caffeine; Chromaffin cell; Cyclopiazonic acid; Dotarizine; Intracellular calcium; Thapsigargin

Indexed keywords

AEQUORIN; ANTIMIGRAINE AGENT; CAFFEINE; CALCIUM ION; CYCLOPIAZONIC ACID; DOTARIZINE; FLUNARIZINE; FURA 2; POTASSIUM ION; THAPSIGARGIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CATTLE; CHROMAFFIN CELL; CONTROLLED STUDY; DNA TRANSFECTION; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL;

ADRENAL MEDULLA; ANIMALS; BENZHYDRYL COMPOUNDS; CAFFEINE; CALCIUM; CATTLE; CELLS, CULTURED; CHROMAFFIN CELLS; FLUNARIZINE; INDOLES; MIGRAINE DISORDERS; PIPERAZINES; POTASSIUM; THAPSIGARGIN; VASODILATOR AGENTS;

EID: 0032744912     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702853     Document Type: Article

References (19)

1. 2+ release in chromaflin cells seen from inside the ER with targeted aequorin. J. Cell Biol., 144, 241-254.
2. 2+] in the endoplasmic reticulum and cytoplasm of intact HeLa cells. A comparative study. J. Biol. Chem., 272, 27694-27699.
3. BRASÓ, A., MARTINEZ, L., PLANAS, J.M., CARTHEUSER, C.F., SACRISTAN, A. & ORTÍZ, J.A. (1996). Pharmacological profile and actions of dotarizine as a prophylactic antimigraine drug. J. Neurol., 243 (Suppl. 2): 6.
4. c). A critical evaluation. J. Biol. Chem., 260, 9896-9903.
5. 2+ stores and activates an influx pathway for divalent cations in HL-60 cells. J. Biol. Chem., 267, 2318-2324.
6. GALIANO, L., MATÍAS-GUIU, J., HORGA, J.F., MARTIN, R., FALIP, R. & MONTIEL, I. (1993). Dotarizine: a double-blind trial in propylactic treatment of migraine. Cephalalgia, 13 (Suppl. 13): 251.
7. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
8. HORGA, J.F., MATIAS-GUIU, J., CASTILLO, J., LAINEZ, J.M., HERNÁNDEZ, M. & FAURA, C.C. (1996). Comparison of dotarizine and pizotifen in prophylactic treatment of migraine: A crossover double-blind multicenter study. 8th World Congress on Pain, Vancouver, Canada, p. 501.
9. 2+ pump protein of sarcoplasmic reticulum. J. Biol. Chem., 266, 22912-22918.
10. +-evoked secretion in chromaffin cells. Am. J. Physiol., 272, C1211-C1221.
11. LIVETT, B.G. (1984). Adrenal medullary chromaffin cells in vitro. Physiol. Rev., 64, 1103-1161.
12. LYTTON, J., WESTLIN, M. & HANLEY, M.R. (1991). Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem., 266, 17067-17071.
13. 2+] subcompartments in intact HeLa cells. J. Cell, Biol., 139, 601 611.
14. 2 receptors. Eur. J. Pharmacol., 332, 183-193.
15. MORO, M.A., LÓPEZ, M.G., GANDÍA, L., MICHELENA, P. & GARCÍA, A. G. (1990). Separation and culture of living adrenaline- and noradrenaline-containing cells from bovine adrenal medullae. Anal. Biochem., 185, 243-248.
16. NEHER, E. (1989). Combined fura-2 and patch-clamp measurements in rat peritoneal mast cells. In: Sellin, L.C., Libelius, R. and Thesleff, S. (eds). Neuromuscular Junctions. Amsterdam: Elsevier pp65-76.
17. 2+. Eur. J. Pharmacol., 366, 309-317.
18. 2+ movements and contractile responses in vascular smooth muscle. Eur. J. Pharmacol., 239, 75-81.
19. VILLARROYA, M., GANDÍA, L., LARA, B., ALBILLOS, A., LÓPEZ, M.G. & GARCÍA, A.G. (1995). Dotarizine versus flunarizine as calcium antagonists in chromaffin cells. Br. J. Pharmacol., 114, 369-376.