Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors

European Journal of Pharmacology

Volumn 332, Issue 2, 1997, Pages 183-193

  Montiel, Carmen ^a   Herrero, Carlos J ^a   García Palomero, Esther ^a   Renart, Jaime ^c   García, Antonio G ^a,b   Lomax, Richard B ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^c CSIC   (Spain)

Author keywords

5 HT2 receptor; Ca2+ channels; Coronary artery; Dotarazine; Xenopus oocytes

Indexed keywords

CALCIUM CHANNEL; DOTARIZINE; ELGODIPINE; FLUNARIZINE; INOSITOL 1,4,5 TRISPHOSPHATE; MESULERGINE; SEROTONIN; SEROTONIN 2 RECEPTOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; FEMALE; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECEPTOR AFFINITY; SWINE; XENOPUS;

ANIMALS; ARTERIES; BENZHYDRYL COMPOUNDS; CALCIUM CHANNEL BLOCKERS; CORONARY VESSELS; FEMALE; FLUNARIZINE; MALE; MICROINJECTIONS; OOCYTES; PIPERAZINES; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SWINE; VASOCONSTRICTION; VASODILATOR AGENTS; XENOPUS LAEVIS;

EID: 0030837641     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01073-X     Document Type: Article

References (29)

1. Brasó, A., Cartheuser, C., Sacristan, A., Ortíz, J.A., 1989. Dotarizine, a promising N-benhydrylpiperazine for migraine prophylaxis due to an additional antiserotoninergic effect. 4th Int. Symp. Calcium Antagonists, Pharmacol. Clin. Res., Florence, Italy, 261 pp.
2. 1 receptors. XIIth Int. Congr. Pharmacol., Montreal, Canada, 409 pp.
3. Cartheuser, C.F., Braso, A., Sacristan, A., Ortíz, J.A., 1994. Effects of dotarizine on peripheral and pulmonary circulation and cardiac dynamics in dogs. Pharmacology 48, 187-193.
4. 5 smooth muscle cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 333, 98-103.
5. Dumont, J.N., 1972. Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals. J. Morphol. 136, 153-180.
6. 1-like receptors linked to increases in intracellular calcium concentration and inhibition of cyclic AMP accumulation in cultured vascular smooth muscle cells derived from bovine basilar artery. J. Pharmacol. Exp. Ther. 266, 692-699.
7. Foguet, M., Hoyer, D., Pardo, L.A., Parekh, A., Kluxen, F.W., Kalkman, H.O., Stühmer, W., Lübbert, H., 1992. Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO J. 11, 3481-3487.
8. Fozard, J.R., 1995. The 5-hydroxytryptamine-nitric oxide connection: The key link in the initiation of migraine?. Arch. Int. Pharmacodyn. Ther. 329, 111-119.
9. Fozard, J.R., Kalkman, H.O., 1994. 5-Hydroxytryptamine (5-HT) and the initiation of migraine: New perspectives. Naunyn-Schmiedeberg's Arch. Pharmacol. 350, 225-229.
10. 1c-like receptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 347, 471-477.
11. Goadsby, P.J., Olesen, J., 1996. Diagnosis and management of migraine. Br. Med. J. 312, 1279-1283.
12. Gundersen, C.B., Miledi, R., Parker, I., 1983. Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes. Proc. R. Soc. London Ser. B 219, 103-109.
13. Horga, J.F., Matias-Guiu, J., Castillo, J., Lainez, J.M., Hernández, M., Faura, C.C., 1996. Comparison of dotarizine and pizotifen in prophylactic treatment of migraine: A crossover double-blind multicentre study. 8th World Congress on Pain. Vancouver, Canada, 501 pp.
14. Martin, G.R., 1994. Vascular receptors for 5-hydroxytryptamine: Distribution, function and classification. Pharmacol. Ther. 62, 283-324.
15. Miledi, R., Parker, I., Sumikawa, K., 1989. Transplanting receptors from brains into oocytes. In: Smith, J. (Ed.), Fidia Award Lecture Series. Raven Press, New York, NY, pp. 57-90.
16. Nomura, Y., Kaneko, S., Kato, K., Yamagishi, S.I., Sugiyama, H., 1987. Inositol phosphate formation and chloride current responses induced by acetylcholine and serotonin through GTP-binding proteins in Xenopus oocyte after injection of rat brain messenger RNA. Mol. Brain Res. 2, 113-123.
17. Parker, I., Ivorra, I., 1991. Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in Xenopus oocytes. J. Physiol. (London) 433, 229-240.
18. 2+ release from isolated platelet membrane vesicles. Biochem. Pharmacol. 36, 3331-3337.
19. Schoeffter, P., Hoyer, D., 1990. 5-Hydroxytryptamine (5-HT)-induced endothelium- dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype. J. Pharmacol. Exp. Ther. 252, 387-395.
20. Sumikawa, K., Parker, I., Miledi, R., 1989. Expression of neurotransmitter receptors and voltage-activated channels from brain mRNA in Xenopus oocytes. In: Conn, P.H. (Ed.), Methods in Neurosciences. Academic Press, San Diego, CA, pp. 30-45.
21. Tamargo, J., López-Sendón, J., Delpón, E., González-Morales, M., de Miguel, E., 1991. Cardiovascular effects of the new dihydropyridine derivative elgodipine. Arzneim.-Forsch. 41, 895-900.
22. 2+ movements and contractile responses in vascular smooth muscle. Eur. J. Pharmacol. 239, 75-81.
23. Todd, P.A., Benfield, P., 1989. Flunarizine. A reappraisal of its pharmacological properties and therapeutic use in neurological disorders. Drugs 38, 481-499.
24. Ullmer, C., Schmuck, K., Kalkman, H.O., Lübbert, H., 1995. Expression of serotonin receptor mRNAs in blood vessels. FEBS-Lett. 370, 215-221.
25. Villarroya, M., Gandía, L., Lara, B., Albillos, A., Löpez, M.G., García, A.G., 1995. Dotarizine versus flunarizine as calcium antagonists in chromaffin cells. Br. J. Pharmacol. 114, 369-376.
26. Weinshank, R.L., Zgombick, J.M., Macchi, M.J., Branchek, T.A., Hartig, P.R., 1992. Human serotonin ID receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc. Natl. Acad. Sci. USA. 89, 3630-3634.
27. Welch, K.M.A., 1993. Drug therapy of migraine. New Engl. J. Med. 329, 1476-1483.
28. - channels in Xenopus oocytes. Mol. Pharmacol. 37, 720-724.
29. Woodward, R.M., Panicker, M.M., Miledi, R., 1992. Actions of dopamine and dopaminergic drugs on cloned serotonin receptors expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 89, 4708-4712.