A randomized safety and tolerability trial of artesunate plus sulfadoxine-pyrimethamine versus sulfadoxine-pyrimethamine alone for the treatment of uncomplicated malaria in Gambian children

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 93, Issue 5, 1999, Pages 543-546

  Doherty, J F ^a   Sadiq, A D ^a   Bayo, L ^a   Alloueche, A ^b   Olliaro, P ^c   Milligan, P ^a   Von Seidlein, L ^a   Pinder, M ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Artesunate; Chemotherapy; Children; Malaria; Plasinodium falciparum; Sulfadoxine pyrimethamine; The Gambia

Indexed keywords

ARTESUNATE; PYRIMETHAMINE; SULFADOXINE;

ARTICLE; BLOOD SMEAR; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; FEMALE; FEVER; GAMBIA; GAMETOCYTE; HUMAN; MALARIA; MALE; PEDIATRICS; RANDOMIZED CONTROLLED TRIAL;

ARTESUNATE; PROTOZOA;

EID: 0032744242     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(99)90376-0     Document Type: Article

References (7)

1. Bojang, K. A., Schneider, G., Forck, S., Obaro, S. K., Jaffar, S., Pinder, M., Rowley, J. & Greenwood, B. M. (1998). A trial of Fansidar® plus chloroquine or Fansidar® alone for the treatment of uncomplicated malaria in Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 73-76.
2. Menon, A., Snow, R. W., Otoo, L. & Greenwood, B. M. (1987). Decline in sensitivity of Plasmodium falciparum to chloroquine in The Gambia. Lancet., i, 1029-1030.
3. Müller, O., Boele van Hensbroek, M., Jaffar, S., Drakeley, C., Okorie, C., Joof, D., Pinder, M. & Greenwood, B. M. (1996). A randomized trial of chloroquine, amodiaquine and pyrimethamine-sulphadoxine in Gambian children with uncomplicated malaria. Tropical Medicine and International Health, 1, 124-132.
4. van Hensbroek, M. B., Morris-Jones, S., Meisner, S., Jaffar, S., Bayo, L. Dackour, R., Phillips, C. & Greenwood, B. M. (1995). Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 672-676.
5. von Seidlein, L., Bojang, K., Jones, P., Jaffar, S., Pinder, M., Obaro, S., Doherty, T., Haywood, M., Snounou, G., Gemperli, B., Gathmann, I., Royce, C., McAdam, K. & Greenwood, B. (1998). A randomized controlled trial of anemether/ benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children. A merican Journal of Tropical Medicine and Hygiene, 58, 638-644.
6. White, N. J. (1996). The treatment of malaria. New England Journal of Medicine, 335, 800-806.
7. White, N. J. & Olliaro, P. L. (1996). Strategies for the prevention of anti-malarial drug resistance: rationale for combination chemotherapy for malaria. Parasitology Today, 12, 399-401.