Pharmacokinetics and pharmacodynamics of rapacuronium in patients with cirrhosis

Anesthesiology

Volumn 91, Issue 5, 1999, Pages 1305-1310

  Duvaldestin, Philippe ^a   Slavov, Velislav ^b   Rebufat, Yves ^b  

^a HENRI MONDOR HOSPITAL   (France)

^b NONE

Author keywords

Liver disease; Neuromuscular relaxants; Plasma concentration

Indexed keywords

3 DESACETYLRAPACURONIUM; RAPACURONIUM BROMIDE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; LIVER CIRRHOSIS; LIVER DISEASE; MALE; NERVE STIMULATION; NEUROMUSCULAR BLOCKING; PHARMACODYNAMICS; PLASMA CLEARANCE; PRIORITY JOURNAL;

ADULT; AGED; ANESTHESIA, GENERAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRIC STIMULATION; FEMALE; HALF-LIFE; HUMANS; LIVER CIRRHOSIS; LIVER FUNCTION TESTS; MALE; MASS SPECTROMETRY; MIDDLE AGED; NEUROMUSCULAR NONDEPOLARIZING AGENTS; ULNAR NERVE; VECURONIUM BROMIDE;

EID: 0032744186     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199911000-00022     Document Type: Article

References (26)

1. Wierda JMKH, Van den Broek L, Proost JH, Verban BW, Hennis PJ: Time course of action and endotracheal intubating conditions of Org 9487, a new short-acting steroidal muscle relaxant: A comparison with succinylcholine. Anesth Analg 1993; 77:579-84
2. Wierda JMKH, Beaufort AM, Kleef UW, Smeulers NJ, Agoston S: Preliminary investigations of the clinical pharmacology of three short-acting non-depolarizing neuromuscular blocking agents, Org 9453, Org 9489 and Org 9487. Can J Anaesth 1994; 41:213-20
3. Bencini AF, Scaf AHJ, Sohn YJ, Meistelman C, Lienhart A, Kersten UW, Schwarz S, Agoston S: Disposition and urinary excretion of vecuronium bromide in anesthetized patients with normal renal function or renal failure. Anesth Analg 1986; 65:245-51
4. Khuenl-Brady K, Castagnoli KP, Canfell PC, Caldwell JE, Agoston S, Miller RD: The neuromuscular blocking effects and pharmacokinetics of Org 9426 Org 9616 in the cat. ANESTHESIOLOGY 1990; 72:669-74
5. Agoston S, Vermeer GA, Kersten UW, Meijer DKF: The fate of pancuronium bromide in man. Acta Anaesthesiol Scand 1973a; 17: 267-75
6. Meijer DKF, Weitering JG, Vonk RJ. Hepatic uptake and biliary excretion of d-tubocurarine and metocurine in man. ANESTHESIOLOGY 1979; 51:402-7
7. Agoston S, Vermeer GA, Kersten UW, Scaf AHJ: A preliminary investigation of the renal and hepatic excretion of gallamine triethiodide in man. Br J Anaesth 1978; 50:345-51
8. Agoston S, Crul EJ, Kersten UW, Houtwerjes MC, Scaf AHJ: The relationship between disposition and duration of action of a congeneric of steroidal neuromuscular blocking agents. Acta Anaesthesiol Scand 1978; 21:24-30
9. Vonk RJ, Westra P, Houwertjes MC, Agoston S: Prolongation by bile salts of the duration of action of a steroidal neuromuscular blocking agent. Br J Anaesth 1979; 51:719-23
10. Westra P, Houwertjes MC, De Lange AR, Scaf AHJ, Hindriks FR, Agoston S: The effect of experimental cholestasis on muscle relaxants in cats. Br J Anaesth 1980; 52:747-57
11. Lebrault C, Berger JL, D'Hollander AA, Gomeni R, Henzel D, Duvaldestin P: Pharmacokinetics and pharmacodynamics of vecuronium (Org NC 45) in patients with cirrhosis. ANESTHESIOLOGY 1985; 62:601-5
12. Magorian T, Wood P, Caldwell JE, Fisher D, Segredo V, Szenohradszky J, Sharma M, Gruenke L, Miller R: The pharmacokinetics and neuromuscular effects of rocuronium bromide in patients with liver disease. Anesth Analg 1995; 80:754-9
13. Van Miert MM, Eastwood, Boyd AH, Parker CJR, Hunter JM: The pharmacokinetics and pharmacodynamics of rocuronium in patients with hepatic cirrhosis. Br J Clin Pharmacol 1997; 44:139-44
14. Szenohradszky J, Caldwell JE, Wright PMC, Brown R, Lau M, Luks AM, Fisher DM: Influence of renal failure on the pharmacokinetics and the pharmacodynamics and neuromuscular effects of a single dose of rapacuronium bromide. ANESTHESIOLOGY 1999; 90:24-35
15. Van den Broek L, Wierda JMKH, Smeulers NJ, Proost JH: Pharmacodynamics and pharmacokinetics of an infusion of Org 9487, a new short-acting steroidal neuromuscular blocking agent. Br J Anaesth 1994; 73:331-5
16. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646-9
17. Duvaldestin P, Agoston S, Henzel D, Kersten UW, Desmonts JM: Pancuronium pharmacokinetics in patients with liver cirrhosis. Br J Anaesth 1978; 50:1131-6
18. Khalil M, Dhonneur G, Duvaldestin P, Slavov V, De Hys C, Gomeni R: Pharmacokinetics and pharmacodynamics of rocuronium in patients with cirrhosis. ANESTHESIOLOGY 1994; 80:1211-7
19. De Wolf AM, Freeman JA, Scott VL, Tullock W, Smith DA, Kisor DF, Kerls S, Cook R: Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation. Br J Anaesth 1996; 76:624-8
20. Kahwaji R, Bevan DR, Bikhazi G, Shanks CA, Fragen RJ, Dyck JB, Angst MS, Matteo R: Dose-ranging study in younger adult and elderly patients of rapacuronium, a new, rapid-onset, short-duration muscle relaxant. Anesth Analg 1997; 84:1011-8
21. Fragen RJ, Shanks CA: Time course of onset and recovery of Org 9487: A comparison with mivacurium and succinylcholine (abstract). ANESTHESIOLOGY 1997; 87(suppl A):A867.
22. Witkowski T, Bartkowski R, Huffnagle S, Lessin J, Marr A, Torhman M: Onset of rapacuronium: A comparison with rocuronium (abstract). ANESTHESIOLOGY 1998; 89(suppl A):A978.
23. Debaene B, Lieutaud T, Billard V, Meistelman C: Org 9487 neuromuscular block at the adductor pollicis and the laryngeal adductor muscles in humans. ANESTHESIOLOGY 1997; 86:1300-5
24. Vanlinthout LEH, Booij LHDJ, Van Egmond J, Robertson EN: Effect of isoflurane ans sevoflurane on the magnitude and time course of neuromuscular block produced by vecuronium, pancuronium and atracurium. Br J Anaesth 1996; 76:389-95
25. Schiere S, Proost JH, Schuringa M, Wierda JMKH: Pharmacokinetics and pharmacokinetic-dynamic relationship between rapacuronium (Org9487) and its 3-desacetyl metabolite (Org 9488). Anesth Analg 1999; 88:640-7
26. Wright PMC, Brown R, Lau M, Fisher DM: A pharmacodynamic explanation for the rapid onset/offset of rapacuronium bromide. ANESTHESIOLOGY 1999; 90:16-23