-
1
-
-
0028853442
-
The contribution of glucose cycling to the maintenance of steady-state levels of lactate by hepatocytes during glycolysis and gluconeogenesis
-
1. Phillips JW, Clark DG, Henly DC, Berry MN. The contribution of glucose cycling to the maintenance of steady-state levels of lactate by hepatocytes during glycolysis and gluconeogenesis. Eur J Biochem 1995;227:352-8.
-
(1995)
Eur J Biochem
, vol.227
, pp. 352-358
-
-
Phillips, J.W.1
Clark, D.G.2
Henly, D.C.3
Berry, M.N.4
-
3
-
-
0027955741
-
Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system
-
3. Sugden MC, Holness MJ. Interactive regulation of the pyruvate dehydrogenase complex and the carnitine palmitoyltransferase system. FASEB J 1994;8:54-61.
-
(1994)
FASEB J
, vol.8
, pp. 54-61
-
-
Sugden, M.C.1
Holness, M.J.2
-
4
-
-
0031923040
-
Hepatic pyruvate dehydrogenase activity in humans: Effect of cirrhosis, transplantation, and dichloroacetate
-
4. Shangraw RE, Rabkin JM, Lopaschuk GD. Hepatic pyruvate dehydrogenase activity in humans: effect of cirrhosis, transplantation, and dichloroacetate. Am J Physiol 1998;274:G569-77.
-
(1998)
Am J Physiol
, vol.274
-
-
Shangraw, R.E.1
Rabkin, J.M.2
Lopaschuk, G.D.3
-
5
-
-
0028566139
-
Kinetic analysis of glycogen synthase and PDC in cirrhotic rat liver and skeletal muscle
-
5. Giardina MG, Matarazzo M, Sacca L. Kinetic analysis of glycogen synthase and PDC in cirrhotic rat liver and skeletal muscle. Am J Physiol 1994;267:E900-6.
-
(1994)
Am J Physiol
, vol.267
-
-
Giardina, M.G.1
Matarazzo, M.2
Sacca, L.3
-
6
-
-
0025286525
-
Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1α, a non-lipoic acid containing mitochondrial enzyme
-
6. Fregeau DR, Roche TE, Davis PA, Coppel R, Gershwin ME. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1α, a non-lipoic acid containing mitochondrial enzyme. J Immunol 1990;144:1671-6.
-
(1990)
J Immunol
, vol.144
, pp. 1671-1676
-
-
Fregeau, D.R.1
Roche, T.E.2
Davis, P.A.3
Coppel, R.4
Gershwin, M.E.5
-
7
-
-
0018579847
-
Lactate elimination in man: Effect of lactate concentration and hepatic dysfunction
-
7. Woll PJ, Record CO. Lactate elimination in man: effect of lactate concentration and hepatic dysfunction. Eur J Clin Invest 1979;9:397-404.
-
(1979)
Eur J Clin Invest
, vol.9
, pp. 397-404
-
-
Woll, P.J.1
Record, C.O.2
-
8
-
-
0028139290
-
Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans
-
8. Shangraw RE, Winter R, Hromco J, Robinson ST, Gallaher EJ. Amelioration of lactic acidosis with dichloroacetate during liver transplantation in humans. Anesthesiology 1994;81:1127-38.
-
(1994)
Anesthesiology
, vol.81
, pp. 1127-1138
-
-
Shangraw, R.E.1
Winter, R.2
Hromco, J.3
Robinson, S.T.4
Gallaher, E.J.5
-
9
-
-
0023238366
-
Problems of bacterial infection in patients with liver disease
-
9. Wyke RJ. Problems of bacterial infection in patients with liver disease. Gut 1987;28:623-41.
-
(1987)
Gut
, vol.28
, pp. 623-641
-
-
Wyke, R.J.1
-
10
-
-
0016285850
-
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
-
10. Whitehouse S, Cooper RH, Randle PJ. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem J 1974; 141:761-74.
-
(1974)
Biochem J
, vol.141
, pp. 761-774
-
-
Whitehouse, S.1
Cooper, R.H.2
Randle, P.J.3
-
11
-
-
0024452528
-
The pharmacology of dichloroacetate
-
11. Stacpoole PW. The pharmacology of dichloroacetate. Metabolism 1989;38:1124-44.
-
(1989)
Metabolism
, vol.38
, pp. 1124-1144
-
-
Stacpoole, P.W.1
-
12
-
-
0025214987
-
The relationship between gluconeogenic substrate supply and glucose production in humans
-
12. Jahoor F, Peters EJ, Wolfe RR. The relationship between gluconeogenic substrate supply and glucose production in humans. Am J Physiol 1990;258(2 Pt 1):E288-96.
-
(1990)
Am J Physiol
, vol.258
, Issue.2 PT 1
-
-
Jahoor, F.1
Peters, E.J.2
Wolfe, R.R.3
-
13
-
-
0026448257
-
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults
-
13. Stacpoole PW, Wright EC, Baumgartner TG, Bersin RM, Buchalter S, Curry SH, et al. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. N Engl J Med 1992;327:1564-9.
-
(1992)
N Engl J Med
, vol.327
, pp. 1564-1569
-
-
Stacpoole, P.W.1
Wright, E.C.2
Baumgartner, T.G.3
Bersin, R.M.4
Buchalter, S.5
Curry, S.H.6
-
14
-
-
0019223718
-
Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration
-
14. Lukas G, Vyas KH, Brindle SD, LeSher AR, Wagner WE Jr. Biological disposition of sodium dichloroacetate in animals and humans after intravenous administration. J Pharm Sci 1980;69:419-21.
-
(1980)
J Pharm Sci
, vol.69
, pp. 419-421
-
-
Lukas, G.1
Vyas, K.H.2
Brindle, S.D.3
LeSher, A.R.4
Wagner W.E., Jr.5
-
15
-
-
0018267924
-
Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells
-
15. Demaugre F, Cepanec C, LeRoux JP. Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cells. Biochem Biophys Res Commun 1978;85:1180-5.
-
(1978)
Biochem Biophys Res Commun
, vol.85
, pp. 1180-1185
-
-
Demaugre, F.1
Cepanec, C.2
LeRoux, J.P.3
-
17
-
-
0029915233
-
Pharmacokinetics of dichloroacetate in patients undergoing liver transplantation
-
17. Shangraw RE, Fisher DM. Pharmacokinetics of dichloroacetate in patients undergoing liver transplantation. Anesthesiology 1996;84:851-8.
-
(1996)
Anesthesiology
, vol.84
, pp. 851-858
-
-
Shangraw, R.E.1
Fisher, D.M.2
-
18
-
-
0015854966
-
Transection of the oesophagus for bleeding oesophageal varices
-
18. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9.
-
(1973)
Br J Surg
, vol.60
, pp. 646-649
-
-
Pugh, R.N.H.1
Murray-Lyon, I.M.2
Dawson, J.L.3
Pietroni, M.C.4
Williams, R.5
-
19
-
-
0025065180
-
Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults
-
19. Georgopolous D, Berezanski D, Anthonisen NR. Effect of dichloroacetate on ventilatory response to sustained hypoxia in normal adults. Respir Physiol 1990;82:115-22.
-
(1990)
Respir Physiol
, vol.82
, pp. 115-122
-
-
Georgopolous, D.1
Berezanski, D.2
Anthonisen, N.R.3
-
20
-
-
0030437931
-
Reduction of serum lactate by sodium dichloroacetate, and human pharmacokinetic-pharmacodynamic relationships
-
20. Fox AW, Sullivan BW, Buffini JD, Neichin ML, Nicora R, Hoehler FK, et al. Reduction of serum lactate by sodium dichloroacetate, and human pharmacokinetic-pharmacodynamic relationships. J Pharmacol Exp Ther 1996;279:686-93.
-
(1996)
J Pharmacol Exp Ther
, vol.279
, pp. 686-693
-
-
Fox, A.W.1
Sullivan, B.W.2
Buffini, J.D.3
Neichin, M.L.4
Nicora, R.5
Hoehler, F.K.6
-
21
-
-
0000083651
-
Methodology of population pharmacokinetics
-
Garrett E, Hirtz J, editors. New York: Marcel Dekker
-
21. Beal SL, Sheiner S. Methodology of population pharmacokinetics. In: Garrett E, Hirtz J, editors. Drug fate and metabolism: methods and techniques. New York: Marcel Dekker; 1985. p. 135-83.
-
(1985)
Drug Fate and Metabolism: Methods and Techniques
, pp. 135-183
-
-
Beal, S.L.1
Sheiner, S.2
-
22
-
-
0028836984
-
Recovery of hepatic drug extraction after hypothermic preservation
-
22. Kelley SD, Cauldwell CB, Fisher DM, Lau M, Sharma ML, Weisiger RA. Recovery of hepatic drug extraction after hypothermic preservation. Anesthesiology 1995;82:251-8.
-
(1995)
Anesthesiology
, vol.82
, pp. 251-258
-
-
Kelley, S.D.1
Cauldwell, C.B.2
Fisher, D.M.3
Lau, M.4
Sharma, M.L.5
Weisiger, R.A.6
-
23
-
-
0018889603
-
Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans
-
23. Wells PG, Moore GW, Rabin D, Wilkinson GR, Oates JA, Stacpoole PW. Metabolic effects and pharmacokinetics of intravenously administered dichloroacetate in humans. Diabetologia 1980;19:109-13.
-
(1980)
Diabetologia
, vol.19
, pp. 109-113
-
-
Wells, P.G.1
Moore, G.W.2
Rabin, D.3
Wilkinson, G.R.4
Oates, J.A.5
Stacpoole, P.W.6
-
25
-
-
0032522741
-
Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid
-
25. Tong Z, Board PG, Anders MW. Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem J 1998;331:371-4.
-
(1998)
Biochem J
, vol.331
, pp. 371-374
-
-
Tong, Z.1
Board, P.G.2
Anders, M.W.3
-
26
-
-
0031041876
-
Glutathione kinetics in normal man and in patients with liver cirrhosis
-
26. Bianchi G, Bugianesi E, Ronchi M, Fabbri A, Zoli M, Marchesini G, Glutathione kinetics in normal man and in patients with liver cirrhosis. J Hepatol 1997;26:606-13.
-
(1997)
J Hepatol
, vol.26
, pp. 606-613
-
-
Bianchi, G.1
Bugianesi, E.2
Ronchi, M.3
Fabbri, A.4
Zoli, M.5
Marchesini, G.6
-
27
-
-
0030726886
-
Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking water
-
27. Gonzalez-Leon A, Schultz IR, Xu G, Bull RJ. Pharmacokinetics and metabolism of dichloroacetate in the F344 rat after prior administration in drinking water. Toxicol Appl Pharmacol 1997;146:189-95.
-
(1997)
Toxicol Appl Pharmacol
, vol.146
, pp. 189-195
-
-
Gonzalez-Leon, A.1
Schultz, I.R.2
Xu, G.3
Bull, R.J.4
-
28
-
-
0030691030
-
Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats
-
28. James MO, Cornett R, Yan Z, Henderson GN, Stacpoole PW. Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats. Drug Metab Dispos 1997;25: 1223-7.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1223-1227
-
-
James, M.O.1
Cornett, R.2
Yan, Z.3
Henderson, G.N.4
Stacpoole, P.W.5
-
29
-
-
0030664873
-
Effect of pretreatment with dichloroacetate or trichloroacetate on the metabolism of bromodichloroacetate
-
29. Austin EW, Bull RJ. Effect of pretreatment with dichloroacetate or trichloroacetate on the metabolism of bromodichloroacetate. J Toxicol Environ Health 1997; 52:367-83.
-
(1997)
J Toxicol Environ Health
, vol.52
, pp. 367-383
-
-
Austin, E.W.1
Bull, R.J.2
-
30
-
-
0020421971
-
Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver
-
30. Keller U, Sonnenberg GE, Burckhardt D, Perruchoud A. Evidence for an augmented glucagon dependence of hepatic glucose production in cirrhosis of the liver. J Clin Endocrinol Metab 1982;54:961-8.
-
(1982)
J Clin Endocrinol Metab
, vol.54
, pp. 961-968
-
-
Keller, U.1
Sonnenberg, G.E.2
Burckhardt, D.3
Perruchoud, A.4
-
31
-
-
0021875875
-
Mechanism of insulin resistance in human liver cirrhosis: Evidence of a combined receptor and post-receptor defect
-
31. Cavallo-Perin P, Cassader M, Bozzo C, Bruno A, Nuccio P, Dall'Omo AM, et al. Mechanism of insulin resistance in human liver cirrhosis: evidence of a combined receptor and post-receptor defect. J Clin Invest 1985;75: 1659-65.
-
(1985)
J Clin Invest
, vol.75
, pp. 1659-1665
-
-
Cavallo-Perin, P.1
Cassader, M.2
Bozzo, C.3
Bruno, A.4
Nuccio, P.5
Dall'Omo, A.M.6
-
33
-
-
0026640045
-
Effects of somatostatin on glucagon-stimulated glycogenolysis and gluconeogenesis in hepatocytes cultured in vitro
-
33. Rosa J, Rosa J, Fister V. Effects of somatostatin on glucagon-stimulated glycogenolysis and gluconeogenesis in hepatocytes cultured in vitro. Acta Physiol Scand 1992;146:205-11.
-
(1992)
Acta Physiol Scand
, vol.146
, pp. 205-211
-
-
Rosa, J.1
Fister, V.2
-
34
-
-
0019276320
-
Dichloroacetate: Its in vivo metabolic effects on carbohydrate metabolism in the conscious dog
-
34. Diamond MP, Rollings RC, Erlendson L, Williams PE, Lacy WW, Rabin D, et al. Dichloroacetate: its in vivo metabolic effects on carbohydrate metabolism in the conscious dog. Diabetes 1980;29:702-9.
-
(1980)
Diabetes
, vol.29
, pp. 702-709
-
-
Diamond, M.P.1
Rollings, R.C.2
Erlendson, L.3
Williams, P.E.4
Lacy, W.W.5
Rabin, D.6
-
35
-
-
0017153013
-
Effect of dichloroacetate on carbohydrate and lipid metabolism of isolated hepatocytes
-
35. Crabb DW, Mapes JP, Boersma RW, Harris RA. Effect of dichloroacetate on carbohydrate and lipid metabolism of isolated hepatocytes. Arch Biochem Biophys 1976;173: 658-65.
-
(1976)
Arch Biochem Biophys
, vol.173
, pp. 658-665
-
-
Crabb, D.W.1
Mapes, J.P.2
Boersma, R.W.3
Harris, R.A.4
-
36
-
-
0024230296
-
Enhanced carrier-mediated lactate entry into isolated hepatocytes from starved and diabetic rats
-
36. Metcalfe HK, Monson JP, Cohen RD, Padgham C. Enhanced carrier-mediated lactate entry into isolated hepatocytes from starved and diabetic rats. J Biol Chem 1988;263:19505-9.
-
(1988)
J Biol Chem
, vol.263
, pp. 19505-19509
-
-
Metcalfe, H.K.1
Monson, J.P.2
Cohen, R.D.3
Padgham, C.4
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