cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein

Molecular Brain Research

Volumn 71, Issue 2, 1999, Pages 159-170

  Malherbe, Pari ^a   Richards, J Grayson ^a   Gaillard, Hélène ^a   Thompson, Annick ^a   Diener, Catherine ^a   Schuler, Angelika ^a   Huber, Gerda ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alzheimer's disease; Amyloid protein; Receptor for advanced glycation end products; Scavenger receptor; Secreted isoform

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID PRECURSOR PROTEIN; CELL SURFACE RECEPTOR; SCAVENGER RECEPTOR;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; DENTATE GYRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; GLYCATION; HIPPOCAMPUS; HISTOCHEMISTRY; MOLECULAR CLONING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE MATTER;

AMINO ACID SEQUENCE; BASE SEQUENCE; BRAIN CHEMISTRY; CELL LINE; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; RECEPTORS, IMMUNOLOGIC;

EID: 0032741165     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00174-6     Document Type: Article

References (26)

1. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid-β protein toxicity. Cell. 77:1994;817-827.
2. Brett J., Schmidt A.M., Zou Y.S., Yan S.D., Weidman E., Pinsky D., Neeper M., Przysiecki C., Shaw A., Migheli A., Stern D. Survey of the distribution of a newly characterized receptor for advanced glycosylation end products in tissues. Am. J. Pathol. 143:1993;1699-1712.
3. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A.Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., Selkoe D.J. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature. 360:1992;672-674.
4. Davis J.B., McMurray H.F., Schubert D. The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes. Biochem. Biophys. Res. Commun. 189:1992;1096-1100.
5. El Khoury J., Hickman S.E., Thomas C.A., Cao L., Silverstein S.C., Loiko J.D. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature. 382:1996;716-719.
6. Gitter B.D., Cox L.M., Rydel R.E., May P.C. Amyloid-β peptide potentiates cytokine secretion by interleukin-1β-activated human astrocytoma cells. Proc. Natl. Acad. Sci. U.S.A. 92:1995;10738-10741.
7. Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostasezwski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., Selkoe D.J. Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature. 359:1992;322-325.
8. Hori O., Brett J., Slattery T., Cao R., Zhang J., Chen J.X., Nagashima M., Lundh E.R., Vijay S., Nitecki D., Morser J., Stern D., Schmidt A.M. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. J. Biol. Chem. 270:1995;25752-25761.
9. Kaltschmidt B., Uherek M., Volk B., Baeuerle P.A., Kaltschmidt C. Transcription factor NF-κB is activated in primary neurons by amyloid-β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94:1997;2642-2647.
10. Klegeris A., Walker D.G., McGeer P.L. Activation of macrophages by Alzheimer β-amyloid peptide. Biochem. Biophys. Res. Commun. 199:1994;984-991.
11. Kyte J., Doolittle R.F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157:1982;105-132.
12. Lander H.M., Tauras J.M., Ogiste J.S., Hori O., Moss R.A., Schmidt A.M. Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress. J. Biol. Chem. 272:1997;17810-17814.
13. Li J., Schmidt A.M. Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products. J. Biol. Chem. 272:1997;16498-16506.
14. Mackic J.B., Stins M., McComb J.G., Calero M., Ghiso J., Kim K.S., Yan S.D., Stern D., Schmidt A.M., Frangione B., Zlokovic B.V. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest. 102:1998;734-743.
15. Malherbe P., Köhler Ch., Da Prada M., Lang G., Kiefer V., Schwarcz R., Lahm H.-W., Cesura A.M. Molecular cloning and functional expression of human 3-hydroxyanthranilic acid dioxygenase. J. Biol. Chem. 269:1994;13792-13797.
16. Matsumoto A., Naito M., Itakura H., Ikemoto S., Asaoka H., Hayakawa I., Kanamori H., Aburatani H., Takaku F., Suzuki H. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc. Natl. Acad. Sci. U.S.A. 87:1990;9133-9137.
17. Neeper M., Schmidt A.M., Brett J., Yan S.D., Wang F., Pan Y.-C.E., Elliston K., Stern D., Shaw A. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J. Biol. Chem. 267:1992;14998-15004.
18. Rauvala H., Pihlaskari R. Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons. J. Biol. Chem. 262:1987;16625-16635.
19. Saura J., Bleuel Z., Ulrich J., Mendelowitsch A., Chen K., Shih J.C., Malherbe P., Da Prada M., Richards J.G. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience. 70:1996;755-774.
20. Schmidt A.M., Vianna M., Gerlach M., Brett J., Ryan J., Kao J., Esposito C., Hegarty H., Hurley W., Clauss M., Wang F., Pan Y.-C.E., Tsang T.C., Stern D. Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface. J. Biol. Chem. 267:1992;14987-14997.
21. Seubert P., Vigo-Pelfrey C., Esch F., Lee M., Dovey H., Davis D., Sinha S., Schlossmacher M., Whaley J., Swindlehurst C., McCormack R., Wolfert R., Selkoe D., Lieberburg I., Schenk D. Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids. Nature. 359:1992;325-327.
22. Sugaya K., Fukagawa T., Matsumoto K., Mita K., Takahashi E., Ando A., Inoko H., Ikemura T. Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. Genomics. 23:1994;408-419.
23. Vissing H., Aagaard L., Tommerup N., Boel E. Localization of the human gene advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3. Genomics. 24:1994;606-608.
24. Yan S.D., Chen X., Fu J., Chen M., Zhu H., Roher A., Slattery T., Zhao L., Nagashima M., Morser J., Migheli A., Nawroth P., Stern D., Schmidt A.M. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature. 382:1996;685-691.
25. Yan S.D., Zhu H., Fu J., Yan S.F., Roher A., Tourtellotte W.W., Rajavashisth T., Chen X., Godman G.C., Stern D., Schmidt A.M. Amyloid-β peptide-receptor for advanced glycation end product interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 94:1997;5296-5301.
26. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.