Molecular chaperones in cilia and flagella: Implications for protein turnover

Cell Motility and the Cytoskeleton

Volumn 44, Issue 4, 1999, Pages 274-283

  Stephens, R E ^a   Lemieux, N A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heat shock protein (HSP); HSP70; HSP90; TCP 1; Tubulin

Indexed keywords

CELL PROTEIN; CHAPERONE; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90;

ANIMAL CELL; ARTICLE; AXONEME; CONTROLLED STUDY; EMBRYO; FLAGELLUM; GASTRULA; GILL; INTRACELLULAR TRANSPORT; MOLLUSC; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN TRANSPORT; PSEUDOPODIUM; RABBIT; SPERMATOZOON; TRACHEA MUCOSA;

ANIMALS; CHAPERONINS; CILIA; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FLAGELLA; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MALE; MOLECULAR CHAPERONES; PHYLOGENY; RABBITS; SEA URCHINS; SPERMATOZOA; TIME FACTORS; TRACHEA;

ANIMALIA; ECHINOIDEA; MOLLUSCA; ORYCTOLAGUS CUNICULUS;

EID: 0032740537     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0169(199912)44:4<274::AID-CM5>3.0.CO;2-O     Document Type: Article

References (46)

1. Allen RL, O'Brien, DA, Eddy, EM. 1988. A novel hsp70-like protein (P70) is present in mouse spermatogenic cells. Mol Cell Biol 8:828-832.
2. Anderson RGW. 1974. Isolation of ciliated or unciliated basal bodies from the rabbit oviduct. J Cell Biol 60:393-404.
3. Bloch MA, Johnson KA. 1995. Identification of a molecular chaperone in the eukaryotic flagellum and its localization to the site of microtubule assembly. J Cell Sci 108:3541-3545.
4. Brown CR, Doxsey SJ, Hong-Brown LQ, Martin RL, Welch WJ. 1996a. Molecular chaperones and the centrosome. A role for TCP-1 in microtubule nucleation. J Biol Chem 271:824-832.
5. Brown CR, Hong-Brown LQ, Doxsey SJ, Welch WJ. 1996b. Molecular chaperones and the centrosome. A role for HSP 73 in centrosomal repair following heat shock treatment. J Biol Chem 271:833-840.
6. Carden MJ, Roobol A. 1995. Neuronal aspects of cytosolic chaperonin complexes: structures implicated in the production of functional cytoskeletal proteins. Biochem Soc Trans 23:70-76.
7. Casano C, Roccheri MC, Onorato K, Cascino D, Gianuzza F. 1998. Deciliation: A stressful event for Paracentrotus lividus embryos. Biochem Biophys Res Commun 248:628-634.
8. Cyrne L, Guerreiro P, Cardoso AC, Rodrigues-Pousada C, Soares H. 1996. The Tetrahymena chaperonin subunit CCTη is coexpressed with CCTγ gene during cilia biogenesis and cell sexual reproduction. FEBS Lett 383:277-283.
9. Dentler WL, Rosenbaum JL. 1977. Flagellar elongation and shortening in Chlamydomonas. III. Structures attached to the tips of flagellar microtubules and their relationship to the directionality of flagellar microtubule assembly. J Cell Biol 74:747-759.
10. Dunn SD. 1986. Effects of the modification of transfer buffer composition and the renaturation of proteins in gels on the recognition of proteins on western blots by monoclonal antibodies. Anal Biochem 157:144-153.
11. Fairbanks GT, Steck, T, Wallach, DFH. 1971. Electrophoretic analysis of the major peptides of the human erythrocyte. Biochemistry 10:2606-2617.
12. Foisner R. 1997. Dynamic organisation of intermediate filaments and associated proteins during the cell cycle. BioEssays 19:297-305.
13. Itoh H, Tashima Y. 1990. The stress (heat shock) proteins. Int J Biochem 23:1185-1191.
14. Johnson KA, Rosenbaum JL. 1992. Polarity of flagellar assembly in Chlamydomonas. J Cell Biol 119:1605-1611.
15. Johnson KA, Rosenbaum JL. 1993. Flagellar regeneration in Chlamydomonas: a model system for studying organelle assembly. Trends Cell Biol 3:156-161.
16. Kozminski KG, Johnson KA, Forscher P, Rosenbaum JL. 1993. A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Nat Acad Sci USA 90:5519-5523.
17. Kubota H, Hynes G, Willson K. 1995. The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Eur J Biochem 230:3-16.
18. Laemmli UK. 1970. Cleavage of the structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
19. Li Q, Suprenant KA. 1994. Molecular characterixation of the 77-kDa echinoderm microtubule-associated protein. Homology to the beta-transducin family. J Biol Chem 269:31777-31784.
20. Liang P, MacRae TH. 1997. Molecular chaperones and the cytoskeleton. J Cell Sci 110:1431-1440.
21. Linck RW, Langevin GL. 1982. Structure and chemical composition of insoluble filamentous components of sperm flagellar microtubules. J Cell Sci 58:1-22.
22. Linck RW, Stephens RE, Tamm SL. 1991. Evidence for tektins in the cilia of the ctenophore Mnemiopsis leidyi. In: Baccetti, B, editor. Comparative spermatology 20 years later. New York: Raven Press Ltd. p 392-395.
23. Morris, RL, Scholey, JM. 1997. Heterotrimeric kinesin-II is requried for the assembly of motile 9+2 axonemes on sea urchin embryos. J Cell Biol 138:1009-1022.
24. Nelson EM. 1975. Regulation of tubulin during ciliary regeneration in non-growing Tetrahymena. Exp Cell Res 94:152-158.
25. O'Farrell PH. 1975. High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021.
26. Piperno G, Mead K. 1997. Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella. Proc Natl Acad Sci USA 94:4457-4462.
27. Portman RW, Dentler WL. 1987. Development of microtubule capping structure in ciliated epithelial cells. J Cell Sci 87:85-94.
28. Roobol A, Holmes FE, Hayes NVL, Baines AJ, Carden MJ. 1995. Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in suhunit composition within single cells. J Cell Sci 108:1477-1488.
29. Rosenbaum JL, Child FM. 1967. Flagellar regeneration of protozoan flagellates. J Cell Biol 34:345-364.
30. Sconzo G, Amore G, Capra G, Guidice G, Cascino D, Ghersi G. 1997. Identification and characterization of a constitutive HSP75 in sea urchin embryos. Biochem Biophys Res Comm 234:24-29.
31. Soares H, Penque D, Mouta C, Rodriques-Pousada C. 1994. A Tetrahymena orthologue of the mouse chaperonin subunit CCTγ and its coexpression with tubulin during cilia recovery. J Biol Chem 269:29299-29307.
32. Song L, Dentler WL. 1998. Turnover of flagellar proteins in Chlamydomonas. Mol Biol Cell 61:398a.
33. Stephens RE. 1970. Thermal fractionation of outer doublet microtubules into A- and B-subfiber components: A- and B-tubulin. J Mol Biol 47:353-363.
34. Stephens RE. 1991. Tubulin in sea urchin embryonic cilia: characterization of the membrane-periaxonemal matrix. J Cell Sci 100:521-531.
35. Stephens RE. 1992. Tubulin in sea urchin embryonic cilia: post-translational modifications during regeneration. J Cell Sci 101:837-845.
36. Stephens RE. 1994. Tubulin and tektin in sea urchin embryonic cilia: pathways of protein incorporation during turnover and regeneration. J Cell Sci 107:683-692.
37. Stephens RE. 1995a. Ciliogenesis in sea urchin embryos: a subroutine in the program of development. BioEssays 17:331-340.
38. Stephens RE. 1995b. Isolation of molluscan gill cilia, sperm flagella, and axonemes. Meth Cell Biol 47:37-42.
39. Stephens RE. 1996. Selective incorporation of architectural proteins into terminally differentiated molluscan gill cilia. J Exp Zool 274:300-309.
40. Stephens RE. 1997. Synthesis and turnover of embryonic sea urchin ciliary proteins during selective inhibition of tubulin synthesis and assembly. Mol Biol Cell 8:2187-2198.
41. Stephens RE. 1999. Turnover of tubulin in ciliary outer doublet microtubules. Cell Struct Funct (in press).
42. Stephens RE, Lemieux NA. 1998. Tektins as structural determinants in basal bodies. Cell Motil Cytoskeleton 40:379-392.
43. Stephens RE, Oleszko S, Linck RW. 1989. Retention of ciliary ninefold structure after removal of microtubules. J Cell Sci 92:391-402.
44. Suprenant KA, Marsh JC. 1987. Temperature and pH govern the self assembly of microtubules from unfertilized sea-urchin eggs. J Cell Sci 87:71-84.
45. Williams NE, Nelsen EM. 1997. HSP70 and HSP90 homologs are associated with tubulin in hetero-oligomeric complexes, cilia and the cortex of Tetrahymena. J Cell Sci 110:1665-1672.
46. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. 1992. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature 358:245-248.