Population frequency, mutation linkage and analytical methodology for the Arg1 6Gly, Gln27Glu and Thr164Ile polymorphisms in the β2-adrenergic receptor among Turks

British Journal of Clinical Pharmacology

Volumn 48, Issue 5, 1999, Pages 761-764

  Aynacioglu, A S ^a,b,d   Cascorbi, I ^a   Gungor K ^c   Ozkur M ^b   Bekir, N ^c   Roots, I ^a   Brockmoller J ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Department of Pharmacology ^*  (Turkey)

^c Medical Faculty   (Turkey)

^d GAZIANTEP UNIVERSITY   (Turkey)

Author keywords

2 adrenergic receptor; Molecular epidemiology; Polymorphism; Turkish population

Indexed keywords

ARGININE; BETA 2 ADRENERGIC RECEPTOR; GLUTAMINE; GLYCINE;

ADULT; ARTICLE; CAUCASIAN; CODON; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; METHODOLOGY; NORMAL HUMAN; POLYMERASE CHAIN REACTION; POPULATION; POPULATION GENETICS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TURKEY (REPUBLIC);

ADOLESCENT; ADULT; ALLELES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, ADRENERGIC, BETA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TURKEY;

EID: 0032735078     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00082.x     Document Type: Article

References (11)

1. 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 1987; 84: 46-50.
2. 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993; 8: 334-339.
3. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994; 33: 9414-9419.
4. 2-adrenergic receptor and asthma. Am J Respir Crit Care Med 1997; 156: S156-S162.
5. 2-adrenergic receptor gene restriction fragment length polymorphism and bronchial asthma. Thorax 1995; 50: 353-359.
6. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995; 345: 1213-1214.
7. 2-adrenoceptor in nocturnal and nonnocturnal asthma. J Clin Invest 1995; 95: 1635-1641.
8. 2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100: 3184-3188.
9. 2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. J Allergy Clin Immunol 1997; 100: 261-265.
10. 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997; 350: 995-999.
11. 11 Aynacioglu AS, Sachse C, Bozkurt A, et al. Low frequency of defective alleles of cytochrome P450 enzymes 2C19 and 2D6 in a Turkish population. Clin Pharmacol Ther 1999; 66: 185-192.