Accurate intracellular localization of HLA-DM requires correct spacing of a cytoplasmic YTPL targeting motif relative to the transmembrane domain

European Journal of Immunology

Volumn 29, Issue 12, 1999, Pages 3936-3944

  Potter, Paul K ^a   Copier, John ^a   Sacks, Steven H ^a   Calafat, Jero ^b   Janssen, Hans ^b   Neefjes, Jacques J ^b   Kelly, Adrian P ^a,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Antigen presentation; HLA DM; MHC

Indexed keywords

CYTOPLASM PROTEIN; HLA D ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; SIGNAL PEPTIDE; TYROSINE;

ANTIGEN PRESENTATION; ARTICLE; CELL SURFACE; ENDOSOME; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; PRIORITY JOURNAL; PROTEIN TARGETING;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CYTOPLASM; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; TRANSFECTION;

EID: 0032732568     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199912)29:12<3936::AID-IMMU3936>3.0.CO;2-K     Document Type: Article

References (24)

1. Neefjes, J., CIIV, MIIC and other compartments for MHC class II loading. Eur. J. Immunol. 1999. 29: 1421-1425.
2. Sanderson, F., Kleijmeer, M. J., Kelly, A., Verwoerd, D., Tulp, A., Neefjes, J., Geuze, H. J. and Trowsdale, J., Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 1994. 266: 1566-1569.
3. Fernandez-Borja, M., Verwoerd, D., Sanderson, F., Aerts, H., Trowsdale, J., Tulp, A. and Neefjes, J., HLA-DM and MHC class II molecules co-distribute with peptidase-containing lysosomal subcompartments. Int. Immunol. 1996. 8: 625-640.
4. Copier, J., Kleijmeer, M. J., Ponnambalam, S., Oorschot, V., Potter, P., Trowsdale, J. T. and Kelly, A., Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB. J. Immunol. 1996. 157: 1017-1027.
5. Marks, M. S., Roche, P. A., Donselaar, E., Woodruff, L., Peters, P. J. and Bonifacino, J. S., A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments. J. Cell Biol. 1995. 131: 351-369.
6. Lindstedt, R., Liljedahl, M., Peleraux, A., Peterson, P. A. and Karlsson, L., The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity 1995. 3: 561-572.
7. Collawan, J. F., Stangel, M., Kuhn, K. A., Esekogwu, V., Jing, S., Trowbridge, I. S. and Tainer, J. L., Transferrin receptor internalisation sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell 1990. 63: 1061-1072.
8. Bos, K., Wraight, C. and Stanley, K., TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain. EMBO J. 1993. 12: 2219-2228.
9. Kornfeld, S., Structure and function of the mannose-6-phosphate/insulin-like growth factor II receptors. Annu. Rev. Biochem. 1992. 61: 307-330.
10. Rohrer, J., Schweizer, A., Russell, D. and Kornfeld, S., The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. J. Cell Biol. 1996. 132: 565-576.
11. Marks, M. S., Woodruff, L., Ohno, H. and Bonifacino, J. S., Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components. J. Cell Biol. 1996. 135: 341-354.
12. Shin, J., Dunbrack, R. L., Lee, S. and Strominger, J. L., Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. J. Biol. Chem. 1991. 266: 10658-10665.
13. Trowbridge, I. S., Collawan, J. F. and Hopkins, C. H., Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol. 1993. 9: 129-161.
14. Sandoval, I. V. and Bakke, O., Targeting of membrane proteins to endosomes and lysosomes. Trends Cell Biol. 1994. 4: 292-297.
15. Hunziker, W. and Geuze, H. J., Intracellular trafficking of lysosomal membrane proteins. BioEssays 1996. 18: 379-389.
16. Hartner, C. and Mellman, I., Transport of the lysosomal membrane glycoprotein Igp120 (Igp-A) to lysosomes does not require appearance on the plasma membrane. J. Cell Biol. 1992. 117: 311-325.
17. Mathews, P. M., Martinie, J. B. and Fambrough, D. M., The pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes. J. Cell Biol. 1992. 118: 1027-1040.
18. Braun, M., Waheed, A. and von Figura, K., Lysosomal acid phosphatase is transported to lysosomes via the cell surface. EMBO J. 1989. 8: 3633-3640.
19. Mayor, S., Presley, J. F. and Maxfield, F. R., Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. J. Cell Biol. 1993. 121: 1257-1269.
20. Gruenberg, J. and Maxfield, F. R., Membrane transport in the endocytic pathway. Curr. Opin. Cell Biol. 1995. 7: 552-563.
21. Ponnambalam, V., Rabouille, C., Luzio, J. P., Nilsson, T. and Warren, G., The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi network. J. Cell Biol. 1994. 125: 253-268.
22. Copier, J. P., Potter, P., Sacks, S. H. and Kelly, A. P., Multiple signals regulate the intracellular trafficking of HLA-DM in B-lymphoblastoid cell. Immunology 1998. 93: 505-510.
23. Chambers, J. D., Simon, S I., Berger, E. M., Sklar, L. A. and Arfors, K.-E., Endocytosis of B2 integrins by stimulated human neutrophils analyzed by flow cytometry. J. Leukoc. Biol. 1993. 53: 462-469.
24. Calafat, J., Janssen, H., Stahle-Backdahl, M., Zuurbier A. E. M., Knol, E. F. and Egesten, A., Human monocytes and neutrophils store transforming growth factor-alpha in a subpopulation of cytoplasmic granules. Blood 1997. 90: 1255-1266.