Expression of interleukin-4 and interferon-γ in the small bowel of patients with dermatitis herpetiformis and isolated gluten-sensitive enteropathy

Digestive Diseases and Sciences

Volumn 44, Issue 10, 1999, Pages 2124-2132

  Smith, Alastair D ^a   Bagheri, Bita ^a   Streilein, Robert D ^a   Hall III, Russell P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dermatitis herpetiformis; Gluten sensitive enteropathy; Interferon ; Interleukin 4

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATITIS HERPETIFORMIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INTESTINE BIOPSY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOPSY; CELIAC DISEASE; DERMATITIS HERPETIFORMIS; DUODENUM; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INTERFERON TYPE II; INTERLEUKIN-4; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032731776     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026699108147     Document Type: Article

References (42)

1. Hall RP: Dermatitis herpetiformis. J Invest Dermatol 99:873-881, 1992
2. Katz SI: Immunopathologic findings. In SI Katz (moderator). Dermatitis Herpetiforimis: The Skin and the Gut. Ann Intern Med 93:857-874, 1980
3. Brow JR, Parker F, Weinstein WM, Rubin CE: The small intestinal mucosa in dermatitis herpetiformis. 1: Severity and distribution of the small intestinal lesion and associated mill-absorption. Gastroenterology 60:355-361, 1971
4. Gawkrodger DJ, McDonald C, O'Mahony S, Ferguson A: Small intestinal function and dietary status in dermatitis herpetiformis. Gut 32:377-382, 1991
5. Fraser NG, Murray D, Alexander JO'D: Structure and function of the small intestine in dermatitis herpetiformis. Br J Dermatol 79:509-518, 1967
6. Fry L, Keir P, McMinn RMH, Cowan JD, Hoffbrand AV: Small-intestinal structure and function and haematological changes in dermatitis herpetiformis. Lancet 2:729-734, 1967
7. Shuster S, Watson AJ, Marks J: Coeliac syndrome in dermatitis herpetiformis. Lancet 1:1101-1106, 1968
8. Marks R, Whittle MW: Results of treatment of dermatitis herpetiformis with a gluten-free diet after one year. BMJ 2:772-775, 1968
9. Fry L, Seah PP, Riches DJ, Hoffbrand AV: Clearance of the skin lesions in dermatitis herpetiformis after gluten withdrawal. Lancet 1:288-291, 1973
10. Heading RC, Paterson WD, McClelland DBL, Barnetson RSt.C, Murray MSM: Clinical response of dermatitis herpetiformis skin lesions to a gluten-free diet. Br J Dermatol 94:509-514, 1976
11. Harrington CI, Read NW. Dermatitis herpetiformis: Effect of gluten-free diet on skin IgA and jejunal structure and function. BMJ 1:872-875, 1977
12. Reunala T: Gluten-free diet in dermatitis herpetiformis. II: Morphological and immunological findings in the skin and small intestine of 12 patients and matched controls. Br J Dermatol 98:69-78, 1978
13. Fry L, Leonard JN, Swain F, Tucker WFG, Raffenden G, Ring N, McMinn RMH: Long term follow-up of dermatitis herpetiformis with and without dietary gluten withdrawal. Br J Dermatol 107:631-640, 1982
14. Leonard JN, Haffenden G, Tucker WFG, Unsworth J, Swain F, McMinn RMH, Holborrow EJ, Fry L: Gluten challenge in dermatitis herpetiformis. N Engl J Med 308:816-819, 1983
15. Spurkland A, Ingvarsson G, Falk ES, Knutsen I, Sollid LM, Thorsby E: Dermatitis herpetiformis and coeliac disease are both primarily associated with the HLA-DQ (α-1-*-0501, β-1-*-02) or the HLA-DQ (α-1-*-03, β-1-*-0302) heterodimers. Tissue Antigens 49:29-34, 1997
16. Marsh MN: Gluten, major histocompatibility complex, and the small intestine. Gastroenterology 102:330-354, 1992
17. Seah PP, Fry L, Stewart JS, Chapman BL, Hoffbrand AV, Holborrow EJ: Immunoglobulins in the skin in dermatitis herpetiformis and coeliac disease. Lancet 1:611-614, 1972
18. Karlsson IJ, Dahl MGC, Marks JM: Absence of cutaneous IgA in coeliac disease without dermatitis herpetiformis. Br J Dermatol 99:621-625, 1978
19. Halstensen TS, Brandtzaeg P: Activated T lymphocytes in the celiac lesion: Non-proliferative activation (CD25) of CD4 -α/β cells in the lamina propria but proliferation (Ki-67) of α/β and γ/δ cells in the epithelium. Eur J Immunol 23:505-510, 1993
20. Lundin KEA, Scott H, Hansen T, Paulsen G, Halstensen TS, Fausa O, Thorsby E, Sollid LM: Gliadin-specific, HLA-DQ (α1*0501, β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178:187-196, 1993
21. Kontakou M, Sturgess RP, Przemioslo RT, Limb GA, Nelufer JM, Ciclitira PJ: Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation. Gut 35:1037-1041, 1994
22. Breese EJ, Kumar P, Farthing MJG, McDonald TT: Interleukin-2 and interferon-γ producing cells in the lamina propria in celiac disease. Dig Dis Sci 39:2243, 1994 (letter)
23. Przemioslo RT, Kontakou M, Nobili V, Ciclitira PJ: Raised pro-inflammatory cytokines interleukin-6 and tumour necrosis factor-α in coeliac disease mucosa detected by immunohistochemistry. Gut 35:1398-1403, 1994
24. Kontakou M, Przemioslo RT, Sturgess RP, Limb AC, Ciclitira PJ: Expression of tumour necrosis factor-α, interleukin-6, and interleukin-2 mRNA in the jejunum of patients with coeliac disease. Scand J Gastroenterol 30:456-463, 1995
25. Przemioslo RT, Lundin KEA, Sollid LM, Nelufer JM, Ciclitira PJ: Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon γ antibody. Gut 36:874-879, 1995
26. Kontakou M, Przemioslo RT, Sturgess RP, Limb GA, Ellis HJ, Day P, Ciclitira PJ: Cytokine mRNA expression in the mucosa of treated coeliac patients after wheat peptide challenge. Gut 37:52-57, 1995
27. Nilsen EM, Lundin KEA, Krajci P, Scott H, Sollid LM, Brandtzaeg P: Gluten specific, HLA-DQ restricted T cell clones from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon γ. Gut 37:766-776, 1995
28. Beckett CG, Dell'Olio D, Kontakou M, Przemioslo RT, Rosen-Bronsen S, Ciclitira PJ: Analysis of interleukin-4 and interleukin-10 and their association with the lymphocytic infiltrate in the small intestine of patients with coeliac disease. Gut 39:818-823, 1996
29. Troncone R, Gianfrani C, Mazzarella G, Greco L, Guardiola J, Auricchhio S, De Berardinis P: Majority of gliadin-specific T-cell clones from celiac small intestinal mucosa produce interferon-γ and interleukin-4. Dig Dis Sci 43:156-161, 1998
30. Nilsen EM, Jahnsen FL, Lundin KEA, Johansen F-E, Fausa O, Sollid LM, Jahnsen J, Scott H, Brandtzaeg P: Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 115:551-563, 1998
31. Walker-Smith J, Guandalini S, Schmitz J, Schmerling D, Visakorpi J: Revised criteria for the diagnosis of coeliac disease. Arch Dis Child 65:909-911, 1990
32. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidinum thiocyanate-phenol-chloroform extraction. Annal Biochem 162:156-159, 1987
33. Pirmez C, Yamamura M, Uyemura K, Paes-Oliveira M, Conceicao-Silva F, Modlin RL: Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 91:1390-1395, 1993
34. Khoury SJ, Hancock WH, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176:1355-1364, 1992
35. Modlin RL, Hofman FM, Horwitz DA, Husmann LA, Gillis S, Taylor CR, Rea TH: In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin-2 and its receptors. J Immunol 132:3085-3090, 1984
36. Cooper CL, Mueller C, Sinchaisri T-A, Pirmez C, Chan J, Kaplan G, Young SM, Weissman IL, Bloom BR, Rea TH: Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in-situ hybridisation. J Exp Med 169:1561-1581, 1989
37. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modlin RL: Defining protective responses to pathogens: Cytokine profiles in leprosy lesions. Science 254:277-279, 1991
38. Ebtekar M, Khansari N: Differential antigenic stimulation influences cytokine production patterns in T cells and CD4 + subpopulations. Scand J Immunol 43:391-397, 1996
39. Lundin KEA, Sollid LM, Anthonsen D, Noren O, Molberg O, Thorsby E, Sjostrom H: Heterogeneous reactivity patterns of HLA-DQ - restricted small intestinal T-cell clones from patients with celiac disease. Gastroenterology 112:752-759, 1997
40. Shidrawi RG, Parnell NDJ, Ciclitira PJ, Travers P, Evan G, Rosen-Bronsen S: Binding of gluten-derived peptides to the HLA-DQ2 (α1*0501, β1*0201) molecule assessed in a cellular assay. Clin Exp Immunol 111:158-165, 1998
41. Arrend W, Dayer J: Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum 33:305-315, 1990
42. Al-Dawoud A, Nakshabendi I, Foulis A, Mowat AMCI: Immunohistochemical analysis of mucosal gamma-interferon production in coeliac disease. Gut 33:1482-1486, 1992