Nitrone spin trapping compound N-tert-butyl-α-phenylnitrone prevents seizures induced by anticholinesterases

Brain Research

Volumn 850, Issue 1-2, 1999, Pages 63-72

  Zivin, Marko ^a,b   Milatovic, Dejan ^b   Dettbarn, Wolf D ^b  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diisopropylphosphorofluoridate; Kainic acid; N tert Butyl phenylnitrone; Physostigmine salicylate; Pilocarpine hydrochloride; Rat; Seizures

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DYFLOS; KAINIC ACID; MESSENGER RNA; N TERT BUTYL ALPHA PHENYLNITRONE; PHYSOSTIGMINE; PILOCARPINE; PROTEIN C FOS;

ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; ENZYME ASSAY; GENE INDUCTION; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; IN VITRO STUDY; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SPIN TRAPPING; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETYLCHOLINESTERASE; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BRAIN; CHOLINESTERASE INHIBITORS; EXCITATORY AMINO ACID AGONISTS; GENES, FOS; GENES, JUN; IN SITU HYBRIDIZATION; ISOFLUROPHATE; KAINIC ACID; MALE; MUSCARINIC AGONISTS; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; PHYSOSTIGMINE; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEIZURES; SPIN LABELS; SPIN TRAPPING;

EID: 0032731529     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)02101-0     Document Type: Article

References (57)

1. Altschul S.F., Gish W., Miller W., Myers E.W., Lipman D.J. Basic local alignment search tool. J. Mol. Biol. 215:1990;403-410.
2. Andersen K.A., Diaz P.T., Wright V.P., Clanton T.L. N-tert-butyl-alpha-phenylnitrone: a free radical trap with unanticipated effects on diaphragm function. J. Appl. Physiol. 80:1996;862-868.
3. Anderson D.E., Yuan X.J., Tseng C.M., Rubin L.J., Rosen G.M., Tod M.L. Nitrone spin traps block calcium channels and induce pulmonary artery relaxation independent of free radicals. Biochem. Biophys. Res. Commun. 193:1993;878-885.
4. Ben-Ari Y., Repressa A., Tremblay E., Nitecka L. Selective and non-selective seizure-related brain damage produced by kainic acid. Adv. Exp. Med. Biol. 203:1986;647-657.
5. Berger M.L., Tremblay E., Nitecka L., Ben-Ari Y. Maturation of kainic acid seizure-brain damage syndrome in the rat: III. Postnatal development of kainic acid binding sites in the limbic system. Neuroscience. 13:1984;1095-1104.
6. Birkle D.L. Regional and temporal variations in the accumulation of unesterified fatty acids and diacylglycerols in the rat brain during kainic acid induced limbic seizures. Brain Res. 613:1993;115-122.
7. Bondy S.C., Lee D.K. Oxidative stress induced by glutamate receptor agonists. Brain Res. 610:1993;229-233.
8. Bose R., Schnell C.L., Pinsky C., Zitko V. Effects of excitotoxins on free radical indices in mouse brain. Toxicol. Lett. 60:1992;211-219.
9. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
10. Braitman D.J., Sparenborg S. MK-801 protects against seizures induced by the cholinesterase inhibitor soman. Brain Res. Bull. 23:1989;145-148.
11. Carney J.M., Floyd R.A. Protection against oxidative damage to CNS by alpha-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: a novel series of nonlipid free radical scavengers. J. Mol. Neurosci. 3:1991;47-57.
12. Carpentier P., Foquin-Tarricone A., Bodjarian N., Rondouin G., Lerner-Natoli M., Kamenka J.M., Blanchet G., Denoyer M., Lallement G. Anticonvulsant and antilethal effects of the phencyclidine derivative TCP in soman poisoning. Neurotoxicology. 15:1994;837-851.
13. Caulfield M.P., Higgins G.A. Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type. Neuropharmacology. 22:1983;347-351.
14. Chan P.H., Fishman R.A., Longar S., Chen S., Yu A. Cellular and molecular effects of polyunsaturated fatty acids in brain ischemia and injury. Prog. Brain. Res. 63:1985;227-235.
15. Chen G., Bray T.M., Janzen E.G., McCay P.B. Excretion, metabolism and tissue distribution of a spin trapping agent a-phenyl-n-tert-butyl-nitrone (PBN) in rats. Free Radic. Res. Commun. 9:1991;317-323.
16. Cheng H.-Y., Liu T., Feuerstein G., Barone F.C. Distribution of spin-traping compounds in rat blood and brain: in vivo microdialysis determination. Free Radic. Biol. Med. 14:1993;243-250.
17. Choi D.W. Methods for antagonizing glutamate neurotoxicity. Cerebrovasc. Brain. Metab. Rev. 2:1990;105-147.
18. Clifford D.B., Olney J.W., Maniotis A., Collins R.C., Zorumski C.F. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures. Neuroscience. 23:1987;953-968.
19. Dragunow M., Beilharz E., Sirimanne E., Lawlor P., Williams C., Bravo R., Gluckman P. Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain. Brain Res. Mol. Brain Res. 25:1994;19-33.
20. Ellman G.L., Courtney K.D., Andres L., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
21. Floyd R.A., Carney J.M. Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann. Neurol. 32:1992;S22-7. Suppl.
22. Fujikawa D.G. Neuroprotective effect of ketamine administered after status epilepticus onset. Epilepsia. 36:1995;186-195.
23. Joseph J.A., Denisova N., Villalobos-Molina R., Erat S., Strain J. Oxidative stress and age-related neuronal deficits. Mol. Chem. Neuropathol. 28:1996;35-40.
24. Koelle G.G., Friedenwald J.S. A histochemical method for localizing acetylcholinesterase activity. Proc. Soc. Exp. Biol. Med. 70:1949;617-622.
25. Kondo T., Sharp F.R., Honkaniemi J., Mikawa S., Epstein C.J., Chan P.H. DNA fragmentation and prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutaze. J. Cereb. Blood Flow Metab. 17:1997;241-256.
26. Lee M.G., Chou J.Y., Lee K.H., Choi B.J., Kim S.K., Kim C.Y. MK-801 augments pilocarpine-induced electrographic seizure but protects against brain damage in rats. Prog. Neuropsychopharmacol. Biol. Psychiatry. 21:1997;331-344.
27. McDonough J.H. Jr., Shih T.M. Pharmacological modulation of soman-induced seizures. Neurosci. Biobehav. Rev. 17:1993;203-215.
28. McLean M.J., Gupta R.C., Dettbarn W-D., Wamil A.W. Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat. Toxicol. Appl. Pharmacol. 112:1992;95-103.
29. Milatovic D., Dettbarn W-D. Reversible inhibition of cholinesterase by spin trapping agents. The Toxicologist. 48:1999;A878.
30. Miner L.L., Marks M.J., Collins A.C. Genetic analysis of nicotine-induced seizures and hippocampal nicotinic receptors in the mouse. J. Pharmacol. Exp. Ther. 239:1986;853-860.
31. Miner L.L., Collins A.C. Strain comparison of nicotine-induced seizure sensitivity and nicotinic receptors. Pharmacol. Biochem. Behav. 33:1989;469-475.
32. Morrisett R.A., Jope R.S., Snead O.C. Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid. Exp. Neurol. 98:1987;594-605.
33. Motte J., Fernandes M.J.S., Baram T.Z., Nehlig A. Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. Brain. Res. 793:1998;61-72.
34. Nitecka L., Tremblay E., Charton G., Bouillot J.P., Berger M.L., Ben-Ari Y. Maturation of kainic acid seizure-brain damage syndrome in the rat: II. Histopathological sequelae. Neuroscience. 13:1984;1073-1094.
35. Olney J.W., Collins R.C., Sloviter R.S. Excitotoxic mechanisms of epileptic brain damage. Adv. Neurol. 44:1986;857-877.
36. Ormandy G.C., Jope R.S., Snead O.C. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats. Exp. Neurol. 106:1989;172-180.
37. Pozas E., Ballabriga J., Planas A.M., Ferrer I. Kainic acid-induced excitotoxicity is associated with a complex c-Fos and c-Jun response which does not preclude either cell death or survival. J. Neurobiol. 33:1997;232-246.
38. Sack C.A., Socci D.J., Crandall B.M., Arendash G.W. Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats. Neurosci. Lett. 205:1996;181-184.
39. Savolainen K.M., Nelson S.R., Samson F.E., Pazdernik T.L. Soman-induced convulsions affect the inositol lipid signaling system: potentiation by lithium; attenuation by atropine and diazepam. Toxicol. Appl. Pharmacol. 96:1988;305-314.
40. Savolainen K.M., Loikkanen J., Naarala J. Amplification of glutamate-induced oxidative stress. Toxicol. Lett. 82-83:1995;399-405.
41. Schulz J.B., Henshaw D.R., Siwek D., Jenkins B.G., Ferrante R.J., Cipolloni P.B., Kowall N.W., Rosen B.R., Beal M.F. Involvement of free radicals in excitotoxicity in vivo. J. Neurochem. 64:1995;2239-2247.
42. Scremin O.U., Li M.G., Scremin A.M., Jenden D.J. Cholinesterase inhibition improves blood flow in the ischemic cerebral cortex. Brain Res. Bull. 42:1997;59-70.
43. Scremin O.U., Shih T.M., Li M.G., Jenden D.J. Mapping of cerebral metabolic activation in three models of cholinergic convulsions. Brain Res. Bull. 45:1998;167-174.
44. Shih T.M., Koviak T.A., Capacio B.R. Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neurosci. Biobehav. Rev. 15:1991;349-362.
45. Sirinathsinghji D.J.S., Morris B.J., Wisden W., Northrop A., Hunt S.P., Dunnett S.B. Gene expression in striatal grafts: I. Cellular localization of neurotransmitter mRNA's. Neuroscience. 34:1999;675-686.
46. Smolders I., Khan G.M., Manil J., Ebinger G., Michotte Y. NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. Br. J. Pharmacol. 121:1997;1171-1179.
47. Socci D.J., Crandall B.M., Arendash G.W. Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res. 693:1995;88-94.
48. Sperk G., Lassmann H., Baran H., Seitelberger F., Hornykiewicz O. Kainic acid-induced seizures: dose-relationship of behavioural, neurochemical and histopathological changes. Brain Res. 338:1985;289-295.
49. Stadtman E.R., Starke-Reed P.E., Oliver C.N., Carney J.M., Floyd R.A. Protein modification in aging. EXS. 62:1992;64-72.
50. Stitzel J.A., Blanchette J.M., Collins A.C. Sensitivity to the seizure-inducing effects of nicotine is associated with strain-specific variants of the alpha 5 and alpha 7 nicotinic receptor subunit genes. J. Pharmacol. Exp. Ther. 284:1998;1104-1111.
51. Sun A.Y., Cheng Y., Bu Q., Oldfield F. The biochemical mechanisms of the excitotoxicity of kainic acid, free radical formation. Mol. Chem. Neuropathol. 17:1992;51-63.
52. Tanaka K., Ogawa N., Mizukawa K., Asanuma M., Kondo Y., Nishibayashi S., Mori A. Acetylcholinesterase inhibitor ENA-713 protects against ischemia- induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia. Neurochem. Res. 19:1994;117-122.
53. Turski L., Ikonomidou C., Turski W.A., Bortolotto Z.A., Cavalheiro E.A. Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse. 3:1989;154-171.
54. Wecker L., Kiauta T., Dettbarn W-D. Relationship between acetylcholinesterase inhibition and the development of a myopathy. J. Pharmacol. Exp. Ther. 206:1978;97-104.
55. Williams M.B., Jope R.S. Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine. Brain Res. Mol. Brain Res. 25:1994;80-89.
56. Yamamoto T., Ohno M., Kitajima I., Yatsugi S., Ueki S. Ameliorative effects of the centrally active cholinesterase inhibitor, NIK-247, on impairment of working memory in rats. Physiol. Behav. 53:1993;5-10.
57. Young D., Dragunow M. Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus. NeuroReport. 5:1993;81-83.