Physiology of protease-activated receptors (PARs): Involvement of PARs in digestive functions

Folia Pharmacologica Japonica

Volumn 114, Issue SUPPL. 1, 1999, Pages 173-179

  Kawabata, Atsufumi ^a   Kuroda, Ryotaro ^a   Hollenberg, Morley D ^b  

^a KINKI UNIVERSITY   (Japan)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Digestive function; Protease activated receptor (PAR); Thrombin; Trypsin

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEINASE; THROMBIN; THROMBIN RECEPTOR; TRYPSIN; TRYPTASE;

AMINO TERMINAL SEQUENCE; ARTICLE; DIGESTIVE FUNCTION; DUODENUM MOTILITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGAND BINDING; PANCREAS JUICE; PROTEIN EXPRESSION; SALIVATION; THROMBOCYTE ACTIVATION;

EID: 0032730870     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.114.supplement_173     Document Type: Article

References (21)

1. Hollenberg MD: Protease-activated receptors: PAR4 and counting: how long is the course? Trends Pharmacol Sci 20, 271-273 (1999).
2. Vu T-KH, Hung DT, Wheaton VI and Coughlin SR: Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanisms of receptor activation. Cell 64, 1057-1068 (1991).
3. Nystedt S, Emilsson K, Wahlestedt C and Sundelin J: Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 91, 9208-9212 (1994).
4. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T and Coughlin SR: Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 386, 502-506 (1997).
5. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese Jr RV, Tam C and Coughlin SR: A dual thrombin receptor system for platelet activation. Nature 394, 690-694 (1998)
6. Xu W-F, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW and Goster DC: Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 95, 6642-6646 (1998).
7. Dery O, Corvera CU, Stenhoff M and Bunnett NW: Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am J Physiol 274, C1429-C1452 (1998).
8. Al-Ani B, Saifeddine M, Kawabata A and Hollenberg MD: Proteinase activated receptor 2: role of extracellular loop 2 for ligand-mediated activation. Br J Pharmacol (in press)
9. Zheng X-L, Renaux B and Hollenberg MD: Parallel contractile signal transduction pathways activated by receptors for thrombin and epidermal growth factor-urogastrone in guinea pig gastric smooth muscle: blockade by inhibitors of mitogen-activated protein kinase-kinase and phosphatidyl inositol 3'-kinase. J Pharmacol Exp Ther 285, 325-334 (1998).
10. Kawabata A, Kuroda R, Nishikawa H and Kawai K: Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation. Br J Pharmacol (in press).
11. 1-targeted ligands. J Pharmacol Exp Ther 288, 358-370(1999).
12. Hollenberg MD, Saifeddine M, Al-Ani B and Kawabata A: Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity and receptor selectivity of receptor-activating peptides. Can J Physiol Pharmacol 75, 832-841(1997).
13. 2-derived peptide ligands. J Pharmacol Exp Ther (in press).
14. Kawabata A, Kuroda R, Minami T, Kataoka K and Taneda M: Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw. Br J Pharmacol 125, 419-422 (1998).
15. Kawabata A, Kuroda R., Nishikawa H, Asai T, Kataoka K and Taneda M: Enhancement of vascular permeability by specific activation of protease-activated receptor-1 in rat hindpaw: a protective role of endogenous and exogenous nitric oxide. Br J Pharmacol 126, 1856-1862 (1999).
16. Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Nelken NA, Coughlin SR, Payan DG and Bunnett NW: Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 314, 1009-1016 (1996).
17. Nguyen TD, Moody NW, Steinhoff M, Okolo C, Koh D-S and Bunnett NW: Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 103, 261-269 (1999).
18. Saifeddine M, Al-Ani B, Cheng C-H, Wang L and Hollenberg MD: Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 118, 521-530 (1996).
19. Corvera CU, Dery O, McConalogue K, Bohm SK, Khitin LM, Caughey G-H, Payan DG and Bunnett NW: Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 100, 1383-1393 (1997)
20. Corvera CU, Dery O, McConalogue K, Gamp P, Thoma M, Al-Ani B, Caughey GH, Hollenberg MD and Bunnett NW: Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2. J Physiol 517, 741-56 (1999).
21. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD: A protective role for protease-activated receptors in the airways. Nature 398, 156-160 (1999).