Computationally derived structural models of the β-amyloid found in Alzheimer's disease plaques and the interaction with possible aggregation inhibitors

Biopolymers

Volumn 50, Issue 7, 1999, Pages 733-741

  George, A R ^a,b   Howlett, D R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NONE   (United Kingdom)

Author keywords

amyloid aggregation; Aggregation inhibitor; Alzheimer's disease; Amyloid precursor protein; Donna Harkay predictions; Fibrillogenesis; Monte Carlo simulations

Indexed keywords

AGGLOMERATION; COMPUTER SIMULATION; DISEASES; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; MONTE CARLO METHODS; POLYPEPTIDES;

ALZHEIMER'S DISEASES; AMYLOID; DONNA-HARKAY PREDICTIONS;

PROTEINS;

4' IODOESORUBICIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; MODEL; PREDICTION; PROTEIN SECONDARY STRUCTURE; SIMULATION; SYSTEM ANALYSIS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; COMPUTATIONAL BIOLOGY; DOXORUBICIN; HUMANS; MODELS, MOLECULAR; MONTE CARLO METHOD; MUTATION; PROTEIN CONFORMATION; SENILE PLAQUES;

EID: 0032729982     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(199912)50:7<733::AID-BIP6>3.0.CO;2-7     Document Type: Article

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