Effects of nicardipine, an antagonist of L-type voltage-dependent calcium channels, on kindling development, kindling-induced learning deficits and hippocampal potentiation phenomena

Neuropharmacology

Volumn 38, Issue 12, 1999, Pages 1841-1850

  Hassan, Hadir ^a   Grecksch, Gisela ^a   Rüthrich, Heinz ^a   Krug, Manfred ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Epilepsy; Kindling induced potentiation; Learning; Nicardipine; PTZ kindling; Voltage dependent calcium channels

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; NICARDIPINE; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DENTATE GYRUS; DRUG ANTAGONISM; ELECTRIC POTENTIAL; EVOKED RESPONSE; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; KINDLING; LEARNING; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; NONHUMAN; PERFORANT NERVE TRACT; PRIORITY JOURNAL; PROVOCATION TEST; RAT; SEIZURE;

ANIMALS; AVOIDANCE LEARNING; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CONVULSANTS; DENTATE GYRUS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; KINDLING, NEUROLOGIC; MALE; NICARDIPINE; PENTYLENETETRAZOLE; RATS; RATS, WISTAR; SEIZURES;

EID: 0032729862     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00067-2     Document Type: Article

References (51)

1. Aldencamp A.P., Alpherts W.C.J., Dekker M.J.A., Overweg J. Neurophysiological aspects. Epilepsia. 31(Suppl. 4):1990;2-8.
2. Barnes C.A., McNaugton B.L. An age comparison of the rats of aquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav. Neurosci. 99, 6:1985;1040-1048.
3. Becker A., Grecksch G. Flunarizine - its effect on pentylenetetrazol-kindled seizures and on related cognitive disturbances. Pharmacol. Biochem. Behav. 52 (4):1995;765-769.
4. Becker A., Grecksch G., Matthies H. The influence of diazepam on learning processes impaired by pentylenetetrazol kindling. Naunyn-Schmiedeberg's Arch. Pharmacol. 349:1994;492-496.
5. Becker A., Grecksch G., Rüthrich H.L., Pohle W., Marx B., Matthies H. Kindling and its consequences on learning in rats. Behav. Neurol. Biol. 57:1992;37-42.
6. Becker A., Grecksch G. Kindling - Anwendung als experimentelles Modell zur Untersuchung kognitiver Dysfunktionen bei Epileptikern. Scheffner D. Epilepsie 1991. 1992;385-389 Einhorn-Presse Verlag, Reinbek.
7. Becker A., Tiedge A., Grecksch G. Diazepam - its effect on development of pentylenetetrazol-kindling, related learning impairments, and neuronal cell loss. Pharmacol. Res. 35(1):1996;27-32.
8. Berger T.W. Long-term potentiation of hippocampal synaptic transmission affects rate of behavioral learning. Science. 224:1984;627-630.
9. Binnie C.D., Channon S., Marston D. Learning disabilities in epilepsia: neurophysiological aspects. Epilepsia. 31 (Suppl. 4):1990;2-8.
10. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
11. Choi D.W., Koh J.-Y., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8:1988;185-196.
12. Collingridge G.L., Bliss T.V.P. NMDA receptors - their role in long-term potentiatiation. Trends Neurosci. 10 (7):1987;288-293.
13. De Longe M., Racine R.J. The development and decay of kindling induced increases in paired-pulse depression in the dentate gyrus. Brain Res. 412:1987;318-328.
14. Dodrill C.B. Correlates of generalized tonic-clonic seizures with intellectuell, neuropsychological, emotional, and social functions in patients with epilepsy. Epilepsia. 27 (Suppl.):1986;105-123.
15. Doerner D., Pacheco M.F., Fowler J.-C., Partridge L.D. The role of calcium in pentylenetetrazol-induced bursting. Comp. Biochem. Physiol. C. 73:1982;9-12.
16. Fisher M., Grotta J. New uses for calcium channel blockers. Therapeutic implications. Drugs. 46(6):1993;961-975.
17. Gasior M., Kaminski R., Brudniak T., Kleinrok Z., Czuczwar S.J. Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. J. Neural Transm. Gen. Sect. 103:1996;819-831.
18. Gilbert M.E., Mack C.M. The NMDA antagonist, MK 801, suppresses long-term potentiation, kindling and kindling-induced potentiation in the perforant path of the unanaesthetized rat. Brain Res. 519:1990;89-96.
19. Giorgino O., Orlandi M., Lecca D.M., Corda M.G. MK 801 prevents chemical kindling induced by pentylenetetrazol in rats. Eur. J. Pharmacol. 193:1991;363-365.
20. Goddard G.V. Development of epileptic seizure through brain stimulation at low intensity. Nature. 214:1967;1020-1021.
21. Herzer, W., 1988. Klinisch-psychologische Untersuchungen zur Psychopathologie bei Epileptikern. Diss. B. W.-Pieck-Universität Rostock.
22. Köhr G., De Koninck Y., Mody I. Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats. J. Neurosci. 13:1993;3612-3627.
23. Köhr G., Mody I. Kindling increases N-methyl-D-aspartate potency at single N-methyl-D-aspartate channels in dentate granule cells. Neurosci. 62:1994;975-981.
24. Krug M., Koch M., Grecksch G., Schulzeck K. Pentylenetetrazol-kindling changes the ability to induce potentiation phenomena in hippocampal CA1 region. Physiol. Behav. 62 (4):1997;721-727.
25. Mason C.R., Cooper R.M. A permanent change in convulsive threshold in normal and brain damaged rats with repeated small doses of pentylenetetrazol. Epilepsia. 13:1972;663-674.
26. McEachern J.C., Shaw C.A. An alternative to the LTP orthodoxy: a plasticity-pathology continuum model. Brain Res. Rev. 22:1996;51-92.
27. McNamara J.O., Bonhaus D.W., Shin C., Crain B.C., Gellmann R.L., Giacchino J.L. The kindling model of epilepsy: a critical review. Crit. Rev. Clin. Neurobiol. 1:1978;341-391.
28. McNaughton B.L., Barnes C.A., Rao G., Baldwin J., Rasmussen M. Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information. J. Neurosci. 6:1986;563-571.
29. McNaughton B.L., Morris R.G.M. Hippocampal synaptic enhancement and information storage within a distributed memory system. Trends Neurosci. 10:1987;408-415.
30. Morrell F., de Toledo-Morrell L. Wada J.A. Kindling as a Model of Neuronal Plasticity, Kindling 3, 1986;17-34 Raven Press, New York.
31. Morris R.G.M. Synaptic plasticity and learning: Selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D aspartate receptor antagonist AP5. J. Neurosci. 9:1989;3040-3057.
32. Morris R.G.M., Anderson E., Lynch G.S., Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate antagonist, AP5. Nature. 319:1986;774-776.
33. Morriset R.A., Chow C., Nadler J.V., McNamara J.O. Biochemical evidence for enhanced sensitivity to N-methyl-D-aspartate in the hippocampal formation of kindled rats. Brain Res. 496:1989;25-28.
34. Moser E.I., Krobert K.A., Moser M.B., Morris R.G.M. Saturation of LTP does impair spatial learning. Eur. J. Neurosci. 10 (Suppl. 10) 56.44:1998;S147.
35. O'Neill S.K., Bolger G.T. Anticonvulsant activity of MK-801 and nimodipine alone and in combination against pentylenetetrazole and strychnine. Pharmacol. Biochem. Behav. 32:1988;595-600.
36. Pedersen M., Dam M. Memory disturbances in epileptic patients. Acta Neurol. Scand. 74 (Suppl. 109):1986;11-14.
37. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroenceph. Clin. Neurophysiol. 32:1972;281-294.
38. Richard M.O. Pharmacokinetics of calcium antagonists. Therapie. 48:1993;651-657.
39. Rüthrich H., Grecksch G., Becker A., Krug M. Potentiation effects in the dendate gyrus of pentylenetetrazol-kindled rats. Physiol. Behav. 60(2):1996;455-462.
40. Rüthrich H., Matthies H., Ott T. Long-term changes in synaptic excitability of hippocampal cell populations as a result of training. Ajmone Marsan C., Matthies H. Neuronal Plasticity and Memory Formation, IBRO Monograph Series 9. 1982;589-594 Raven Press, New York.
41. Sato K., Morimoto K., Okamoto M. Anticonvulsant action of a non-competitive antagonist of NMDA-receptors (MK 801) in the kindling model of epilepsy. Brain Res. 463:1988;12-20.
42. Schröder H., Becker A., Lössner B. Glutamate binding to membranes is increased in pentylenetetrazol-kindled rats. Journal of Neurochemistry. 1993;1007-1011 Raven Press, New York.
43. D-aspartate release in the hippocampus of rat after pentylenetetrazol kindling and long-term potentiation. Neuroscience. 60 (2):1994;337-342.
44. Skinner J.E. Neuroscience: A Laboratory Manual. 1971;Saunders, Philadelphia.
45. Stringer J.L., Lothman E.W. Use of maximal dentate activation to study the effect of drugs on kindling and kindled responses. Epilepsy Res. 6:1990;180-186.
46. Teyler T.J., Cavus I., Coussens C., Discenna P., Grover L., Lee Y.P., Little Z. Multideterminant role of calcium in hippocampal synaptic plasticity. Hippocampus. 4 (6):1994;623-634.
47. Voigt P., Morgenstern E. Pentylenetetrazol kindling impairs memory in mice. Biomed. Biochem. Acta. 14:1986;115-120.
48. Wasterlain C.G., Jonec V. Chemical kindling by muscarinergic amygdaloid stimulation in the rat. Brain Res. Rev. 7:1984;15-28.
49. Wasterlain C.G., Morin A.M., Fujkawa D.G., Bronstein J.M. Chemical kindling. Bolwing T.G., Trimble M.R. The Clinical Relevance of Kindling. 1989;35-73 John Wiley, New York.
50. Watkins, J.C., Collingridge, G.L. (Hrsg.), 1989. The NMDA Receptor. IRL Press, Oxford University Press, Oxford.
51. Zornow M.H., Prough P.S. Neuroprotective properties of calcium-channel blockers. New-Horiz. 4(1):1996;107-114.