Diazepam - Its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss

Pharmacological Research

Volumn 35, Issue 1, 1997, Pages 27-32

  Becker, Axel ^a   Tiedge, Anja ^a   Grecksch, Gisel A ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cell loss; Diazepam; Epilepsy; Kindling; Learning; Pentylenetetrazol; Rat; Shuttle box

Indexed keywords

DIAZEPAM; PENTETRAZOLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CELL LOSS; COGNITIVE DEFECT; HIPPOCAMPUS; KINDLING; LEARNING DISORDER; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

EID: 0030945496     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1996.0116     Document Type: Article

References (43)

1. 1. Dodrill CB. Correlates of generalized tonic-clonic seizures with intellectual, neuropsychological, emotional, and social function in patients with epilepsy. Epilepsia 1986; 27: 399-411.
2. 2. Halgren E, Stapleton J, Domalski P, Swartz BE, Delgato-Escueta AV, Walsh GO, Mandelkern M, Blahd M, Ropach J. Memory dysfunctions in epilepsy patients as a dearrangement of normal psychology. In: Smith D, Treitman T, Trimble M, eds. Advances in neurology, Vol 55. New York: Raven Press, 1991: 385-410.
3. 3. Lesser RP, Lüders H, Wylli E, Dinner DS and, Morris III HH. Mental deterioration in epilepsy. Epilepsia 1986; 27 (Suppl. 2): S105-S23.
4. 4. Levin R, Banks S and, Berg B. Psychosocial dimensions of epilepsy: a review of the literature. Epilepsia 1986; 27: 399-411.
5. 5. Thiebot MH. Some evidence for amnestic-like effects of benzodiazepines in animals. Neurosci Biobehav Rev 1985; 9: 95-100.
6. 6. Thompson J. Memory functions in patients with epilepsy. In: Smith D, Treitman D, Trimble M, eds. Advances in neurology, Vol. 55. New York: Raven Press, 1991: 369-84.
7. 7. Hunger J and, Klein J. Psychological tests by epileptic patients. Arch Psychiatrie Nervenkrank 1983; 233/234: 307-325.
8. 8. Scott DF, Moffatt A, Matthews A and, Ettlinger G. The effect of epileptic discharges on learning and memory in patients. Epilepsia 1967; 8: 188-94.
9. 9. Cavazos JE and, Sutula TP. Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis. Brain Res 1990; 527: 1-6.
10. 10. Cavazos JE, Das I and, Sutula TP. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures. J Neurosci 1994; 14: 3106-21.
11. 11. Golarai GG, Cavazos JE and, Sutula PT. Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization. Brain Res 1992; 593: 257-64.
12. 12. Pohle W, Becker A, Grecksch G, Juhre A and, Willenberg A. Piracetam prevents pentylenetetrazol-kindling induced neuronal loss and related learning deficits. Seizure; (in press).
13. 13. Becker A, Grecksch G and, Matthies H. The influence of diazepam on learning processes impaired by pentylenetetrazol. Naunyn-Schmiedeberg's Arch Pharmacol 1994; 349: 492-6.
14. 14. Becker A, Grecksch G, Rüthrich HL, Pohle W, Marx B and, Matthies H. Kindling and its consequences on learning in rats. Behav Neural Biol 1992; 57: 37-43.
15. 3H]D-aspartate release in the hippocampus of rats after pentylenetetrazol kindling and long-term potentiation. Neurosci 1994; 60: 337-42.
16. 16. Clark M, Massenburg GS, Weiss SRB and, Post RM. Analysis of hippocampal GABA(A) receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine. Mol Brain Res 1994; 26: 309-19.
17. 17. Clarke PRF, Eccersley PS, Frisby JP and, Thornton JA. The amnestic effect of diazepam (valium). Brit J Anaest 1970; 42: 690-7.
18. 18. File SE and, Mabbutt PS. Performance in learning tasks after a period of chlordiazepoxide administration in the rat. Pharmacopsycho-ecologia 1989; 2: 43-8.
19. 19. File SE, Mabbutt PS and, Toth EA. Comparison of the effects of diazepam and scopolamine in two positively reinforced learning tasks. Pharmacol Biochem Behav 1990; 37: 587-92.
20. 20. Ghoneim MM and, Mewaldt SP. Benzodiazepines and human memory: a review. Anaesthesiol 1990; 72: 926-38.
21. 21. Hodges H and, Green S. Effect of chlordiazepoxid on cued radial maze performance in rats. Psychopharmacol 1986; 88: 460-6.
22. 22. Lister RG. The amnestic effect of benzodiazepines in man. Neurosci Biobehav Rev 1995; 9: 87-94.
23. 23. Jensen RA, Martinez JL, Vasquez BJ and, McGaugh JL. Benzodiazepines alter acquisition and retention of an inhibitory avoidance response in mice. Psychopharmacol 1979; 64: 125-26.
24. 24. Tohayama K, Nabeshima T, Ichihara K and, Kameyama T. Involvement of GABAergic systems in benzodiazepine-induced impairments in passive avoidance learning in mice. Psychopharmacol 1991; 105: 22-6.
25. 25. Bignami G. Behavioral pharmacology and toxicology. Ann Rev Pharmacol Toxicol 1976; 16: 329-66.
26. 26. Sansone M, Vetulani J and, Hano J. Effects of chloraiazepoxide on acquisition of avoidance behaviour in mice receiving chronically antidepressant drugs. Pharmacol Res Commun 1981; 13: 265-74.
27. 27. Dantzer R. Behavioural effects of benzodiazepines: a review. Biobehav Rev 1977; 1: 71-86.
28. 28. Fernandez-Teruel A, Escorihuela RM, Nunez JF, Zapata A, Boix F, Salazar W and, Tobena A. The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation. Brain Res Bull 1991; 26: 173-6.
29. 29. Fernandez-Teruel A, Escorihuela RM, Tobena A and, Driscoll P. Stressful situations and putative endogenous ligands for benzodiazepine receptors: the importance of controlling the specific characteristics of the aversive situation and differential emotionality in experimental animals. Experientia 1991; 47: 1051-6.
30. 30. Driscoll P, Ferre P, Fernandez-Teruel A, de Stein M, Wolfman C, Medina J, Tobena A and, Escorihuela RM. Effects of prenatal diazepam on two-way avoidance behavior, swimming navigation and brain levels of benzodiazepine-like molecules in male Roman high-and low-avoidance rats. Psychopharmacol 1995; 122: 51-7.
31. 31. Ghoneim MM, Mewaldt SP, Berie JL and, Hinrichs JV. Memory and performance effects of single and 3-week administration of diazepam. Psychopharmacol 1981; 73: 147-51.
32. 32. Tata PR, Rollings J, Collins M, Pickering A and, Jacobsen RR. Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychol Med 1994; 24: 203-13.
33. 33. Ben-Attia M, N'Gouemo P, Belaidi M, Rondouni G and, Chicheprotiche R. Kindling and electrode effects on benzodiazepine receptors density of olfactory bulk and hippocampus after olfactory bulb kindling. Neurosci Lett 1992; 143: 74-8.
34. 34. Farelli RJ and, McNamara JO. Effects of age on kindling and kindled seizure-induced increase of benzodiazepine receptor binding. Brain Res 1986; 362: 17-22.
35. 35. Shin C, Pedersen HB and, McNamara JO. Gamma-aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study. J Neurosci 1985; 5: 2696-701.
36. 36. Slovitter RS. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 1987; 235: 73-6.
37. 3H]flunitrazepam binding in kindled rat hippocampus. Neurosci 1995; 68: 399-406.
38. 38. Nobrega JN, Kish SJ and, McIntyre-Burnham W. Autoradiographic analysis of benzodiazepine binding in entorhinal-kindled rat brains. Brain Res 1989; 498: 315-22.
39. 39. Rocha L, Ackermann RF, Chugani HT and, Engel JJr. Chronic pretreatment with naloxone modifies benzodiazepine receptor binding in amygdaloid kindled rats. Epilepsy Res 1994; 17: 135-43.
40. 40. O'Rourke DM, Saykin AJ, Gilhool JJ, Harley R, O'Connor MJ and, Sperling MR. Unilateral hemispheric memory and hippocampal neuronal density intemporal lobe epilepsy. Neurosurgery 1993; 32: 574-81.
41. 41. Sass KJ, Spencer DD, Kim JH, Westerveld M, Novelly RA and, Lencz T. Verbal memory impairment correlates with hippocampal pyramidal cell density. Neurology 1990; 40: 1694-7.
42. 42. Slovitter RS. Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 1987; 235: 73-6.
43. 43. Fern R, Ramson BR, Stys PK and, Waxman SG. Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepin and diazepam. J Pharmacol Exp Therap 1993; 266: 1549-55.