Strategies for screening for hereditary non-polyposis colorectal cancer

Journal of Medical Genetics

Volumn 36, Issue 11, 1999, Pages 819-822

  Loukola, Anu ^a   De la Chapelle, Albert ^b   Aaltonen, Lauri A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Colon cancer; HNPCC; MSI; Screening

Indexed keywords

ARTICLE; BASE MISPAIRING; CANCER SCREENING; CLINICAL FEATURE; COLORECTAL CANCER; DNA REPAIR; FAMILIAL CANCER; FAMILY HISTORY; GENE MUTATION; GERM LINE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MICROSATELLITE INSTABILITY; PEDIGREE; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RELATIVE;

ADULT; AGED; BASE PAIR MISMATCH; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; GENETIC SCREENING; GERM-LINE MUTATION; HUMANS; MIDDLE AGED; MODELS, THEORETICAL;

EID: 0032728684     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1996. CA Cancer J Clin 1996;46:5-27.
2. Phillips RKS, Spigelman AD, Thompson JPS, eds. Familial adenomatous polyposis and other polyposis syndromes. London: Edward Arnold, 1994.
3. Mecklin JP, Järvinen HJ, Hakkiluoto A, et al. Frequency of hereditary nonpolyposis colorectal cancer. A prospective multicenter study in Finland. Dis Colon Rectum 1995,38:588-93.
4. Lynch HT, Smyrk TC. Identifying hereditary nonpolyposis colorectal cancer N Engl J Med 1998;338:1537-8.
5. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998;338:1481-7.
6. Järvinen H, Mecklin JP, Sistonen P. Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer Gastroenterology 1995;108:1405-11.
7. Dunlop MG, Farrington SM, Carothers AD, et al. Cancer risk associated with germline DNA mismatch repair gene mutations. Hum Mol Genet 1997;6:105-10.
8. Vasen HF, van Ballegooijen M, Buskens E, et al. A cost-effectiveness analysis of colorectal screening of hereditary nonpolyposis colorectal carcinoma gene carriers. Cancer 1998;2:1632-7.
9. Aarnio M, Sankila R, Pukkala E, et al. Cancer risk in mutation carriers of DNA mismatch repair genes. Int J Cancer 1999;81:214-18.
10. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;18:159-70.
11. Wijnen JT, Vasen HFA, Khan PM, et al. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. N Engl J Med 1998;339:511-18.
12. Douglas FS, O'Dair LC, Robinson M, Evans DGR, Lynch SA. The accuracy of diagnosis as reported in families with cancer: a retrospective study. J Med Genet 1999;36:309-12.
13. Aaltonen LA, Peltomäki P, Mecklin JP, et al. Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994;-54:1645-8.