Physiologically based toxicokinetic modeling of inhaled ethyl tertiary- butyl ether in humans

Toxicological Sciences

Volumn 51, Issue 2, 1999, Pages 184-194

  Nihlén, Annsofi ^a   Johanson, Gunnar ^a,b  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Biological monitoring; Ethyl tertiary butyl ether (ETBE); Gasoline; Inhalation exposure; Methyl tertiary butyl ether (MTBE); Oxygenates; Physiologically based toxicokinetic (PBTK) model; Risk assessment; Tertiary butyl alcohol (TBA); Toxicokinetics

Indexed keywords

BIOLOGICAL MARKER; ETHER DERIVATIVE; GASOLINE; TERT BUTYL ALCOHOL;

ARTICLE; BIOLOGICAL MONITORING; BODY COMPOSITION; CALCULATION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; MODEL; ORGAN BLOOD FLOW; ORGAN SIZE; PARTITION COEFFICIENT; PHYSICAL ACTIVITY; PREDICTION; SIMULATION; SYSTEM ANALYSIS; TOXICOKINETICS; URINARY EXCRETION;

BIOLOGICAL MARKERS; BODY FLUID COMPARTMENTS; ETHYL ETHERS; GASOLINE; HUMANS; INDIVIDUALITY; INHALATION EXPOSURE; LUNG; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; TERT-BUTYL ALCOHOL;

EID: 0032727969     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/51.2.184     Document Type: Article

References (28)

1. Andersen, M. E., Clewell, H. J., 3rd, and Frederick, C. B. (1995). Applying simulation modeling to problems in toxicology and risk assessment - a short perspective. Toxicol. Appl. Pharmacol. 133, 181-187.
2. Åstrand, P.-O., and Rodahl, K. (1986). Textbook of Work Physiology: Physiological Bases of Exercise. McGraw-Hill, Singapore.
3. Baker, G. L. (1969). Human adipose tissue composition and age. Am. J. Clin. Nutr. 22, 829-835.
4. 13C nuclear magnetic resonance and gas chromatography/mass spectrometry. Chem. Res. Toxicol. 11, 651-658.
5. Borghoff, S. J., Murphy, J. E., and Medinsky, M. A. (1996). Development of a physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats. Fundam. Appl. Toxicol. 30, 264-275.
6. Clewell, H. J., 3rd, and Andersen, M. E. (1996). Use of physiologically based pharmacokinetic modeling to investigate individual versus population risk. Toxicology 111, 315-329.
7. Droz, P. O. (1992). Quantification of biological variability. Ann. Occup. Hyg. 36, 295-306.
8. Fiserova-Bergerova, V. (1983). Modeling of inhalation exposure to vapors: Uptake, distribution, and elimination. In Gases and Their Solubility: a Review of Fundamentals. (V. Fiserova-Bergerova, Ed.), Vol. 1, pp. 3-28. CRC Press, Boca Raton, Florida.
9. Hakkola, M., Honkasalo, M. L., and Pulkkinen, P. (1996). Neuropsychological symptoms among tanker drivers exposed to gasoline. Occup. Med. 46, 125-130.
10. HEI (1996). "The potential health effects of oxygenates added to gasoline: A review of the current literature. A special report of the institute's oxygenates evaluation committee." Health Effects Institute, Cambridge, MD.
11. Johanson, G. (1997). Toxicokinetics: Modeling disposition. In Comprehensive Toxicology. (I. Sipes, A. Gandolfi, and C. McQueen, Eds.), Vol. 1, pp. 167-188. Amsterdam Elsevier, Amsterdam, The Netherlands.
12. Johanson, G., and Näslund, P. H. (1988). Spreadsheet programming - a new approach in physiologically based modeling of solvent toxicokinetics. Toxicol. Lett. 41, 115-127.
13. Järnberg, J., and Johanson, G. (1999). Physiologically based modeling of 1,2,4-trimethylbenzene inhalation toxicokinetics. Toxicol. Appl. Pharmacol. 155, 203-214.
14. Järnberg, J., Ståhlbom, B., Johanson, G., and Löf, A. (1997). Urinary excretion of dimethylhippuric acids in humans after exposure to trimethylbenzenes. Int. Arch. Occup. Environ. Health 69, 491-497.
15. Löf, A., and Johanson, G. (1998). Toxicokinetics of organic solvents: a review of modifying factors. Crit. Rev. Toxicol. 28, 571-650.
16. Nihlén, A., Löf, A., and Johanson, G. (1995). Liquid/air partition coefficients of methyl- and ethyl t-butyl ethers, t-amyl methyl ether, and t-butyl alcohol. J. Expos. Anal. Environ. Epidemiol. 5, 573-582.
17. Nihlén, A., Löf, A., and Johanson, G. (1998). Controlled ethyl tertiary-butyl ether (ETBE) exposure of male volunteers: I. Toxicokinetics. Toxicol. Sci. 46, 1-10.
18. 13C-labeled methyl t-butyl ether: Toxicokinetics and characterization of urinary metabolites in humans. Chem. Res. Toxicol., in press.
19. Ong, C.-N., and Lee, B.-L. (1994). Determination of benzene and its metabolites: Application in biological monitoring of environmental and occupational exposure to benzene. J. Chromatogr. B Biomed. Appl. 660, 1-22.
20. Pekari, K., Riihimäki, V., Vainiotalo, S., Teräväinen, E., and Aitio, A. (1996). Experimental exposure to methyl-tert-butyl ether (MTBE) and methyl-tert-amyl ether (MTAE). Proceedings from the International Symposium on Biological Monitoring in Occupational and Environmental Health, Hanasaari Cultural Centre, Espoo, Finland.
21. Pelekis, M., Poulin, P., and Krishnan, K. (1995). An approach for incorporating tissue composition data into physiologically based pharmacokinetic models. Toxicol. Ind. Health. 11, 511-522.
22. Petreas, M. X., Woodlee, J., Becker, C. E., and Rappaport, S. M. (1995). Retention of styrene following controlled exposure to constant and fluctuating air concentrations. Int. Arch. Occup. Environ. Health 67, 27-34.
23. 8-toluene toxicokinetics assessed by semiempirical physiologically based model. Toxicol. Appl. Pharmacol. 139, 49-61.
24. Rao, H. V., and Ginsberg, G. L. (1997). A physiologically based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination. Risk Anal. 17, 583-598.
25. Savolainen, H., Pfäffli, P., and Elovaara, E. (1985). Biochemical effects of methyl tertiary-butyl ether in extended vapour exposure of rats. Arch. Toxicol. 57, 285-288.
26. Te Koppele, J. M. (1992). 2-Methylpropanol-2. In Ethel Browning's Toxicology and Metabolism of Industrial Solvents (R. Thurman and F. Kauffman, Eds.), Vol. 3., pp. 65-76. Elsevier Science Publishers B. V., Amsterdam, The Netherlands.
27. U.S. EPA (1993). Assessment of Potential Health Risks of Gasoline Oxygenated with Methyl tertiary Butyl Ether (MTBE). EPA/600/R-93/206, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC.
28. White, R. D., Daughtrey, W. C., and Wells, M. S. (1995). Health effects of inhaled tertiary amyl methyl ether and ethyl tertiary butyl ether. Toxicol. Lett. 82/83, 719-724.