Simultaneous vitamin A administration at routine immunization contact enhances antibody response to diphtheria vaccine in infants younger than six months

Journal of Nutrition

Volumn 129, Issue 12, 1999, Pages 2192-2195

  Rahman, M M ^a   Mahalanabis, D ^a,b   Hossain, S ^a   Wahed, M A ^a   Alvarez, J O ^c   Siber, G R ^d   Thompson, Claudette ^d   Santosham, M ^e   Fuchs, G J ^a  

^a ICDDR B Centre for Health and Population Research   (Bangladesh)

^b Society for Applied Research   (India)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d Massachusettes Pub Hlth B   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Antibody; Diphtheria; Immunization; Infants; Pertussis; Tetanus; Vitamin A

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS VACCINE; IMMUNOGLOBULIN G ANTIBODY; PLACEBO; RETINOL;

ANTIBODY RESPONSE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIPHTHERIA; DOUBLE BLIND PROCEDURE; DRUG POTENTIATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; MALE; ORAL DRUG ADMINISTRATION; PERTUSSIS; RANDOMIZED CONTROLLED TRIAL; TETANUS; VACCINATION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

EID: 0032726745     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.12.2192     Document Type: Article

References (39)

1. Arthur, P., Kirkwood, B., Ross, D., Morris, S., Gyapong, J., Tomkins, A. & Addy, H. (1992) Impact of vitamin A supplementation on childhood morbidity in Northern Ghana. Lancet 339: 361-362.
2. Barclay, A. J., Foster, A. & Sommer, A. (1987) Vitamin A supplements and mortality related to measles: a randomized clinical trial. Br. Med. J. 294; 294-296.
3. Barreto, M. L., Santos, L. M., Assis, A. M., Araugo, M. P., Farenzena, G. G., Santos, P. A. & Fiaccone, R. L. (1994) Impact of vitamin A supplementation on diarrhoea and acute lower respiratory infections in preschool children in Northeast Brazil. Lancet 344: 228-231.
4. Blomhoff, H. K., Smeland, E. B., Erikstein, B., Rasmussen, A. M., Skrede, B., Skyonsberg, C. & Blomhoff, R. (1992) Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells. J. Biol. Chem. 267: 23988-23992.
5. Brown, K. H., Rajan, M. M., Chakraborty, J. & Aziz, K.M.A. (1980) Failure of a large dose of vitamin A to enhance the antibody response to tetanus toxoid in children. Am. J. Clin. Nutr. 33: 212-217.
6. Carman, J. A., Smith, S. M. & Hayes, C. E. (1989) Characterization of a helper T lymphocyte defect in vitamin A deficient mice. J. Immunol. 142: 388-393.
7. Catignani, G. L. & Bieri, J. G. (1983) Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography. Clin. Chem. 29: 708-712.
8. Chandra, R. K. & Au, B. (1981) Single nutrient deficiency and cell-mediated immune responses. III. Vitamin A. Nutr. Res. 1: 181-185.
9. Dennert, G. (1984) Retinoids and the immune system: immune stimulation by vitamin A. In: The Retinoids (Sporn, M. B., ed.), pp. 373-390. Academic Press, Orlando, FL.
10. Englund, J. A., Glezen, W. P., Thompson, C., Anwaruddin, R., Turner, C. S., Siber, G. R. (1997) Haemophilus influenzae type b-specific antibody in infants after maternal immunization. Pediatr. Infect. Dis. J. 16: 112-130.
11. Ghana VAST Study Team (1993) Vitamin A supplementation in northern Ghana: effects on clinic attendance, hospital admissions, and child mortality. Lancet 342: 7-12.
12. Glaziou, P. I. & Mackerras, D.E.M. (1993) Vitamin A supplementation and infectious disease: a metanalysis. Br. Med. J. 306: 366-370.
13. Hussey, G. H. & Klein, M. B. (1990) A randomized controlled trial of vitamin A in children with severe measles. N. Engl. J. Med. 323: 160-164.
14. Islam, M. A., Thilsted, D. H. & Mahalanabis, D. (1992) Evaluation of preventive health services for hospitalised children under a child health programme. J. Diarrhoeal Dis. Res. 10: 205-212.
15. Israel, H., Odziemiec, C. & Ballow, M. (1991) The effects of retinoic acid on immunoglobulin synthesis by human cord blood monouclear cells. Clin. Immunol. Immunopathol. 59: 417-425.
16. Mahalanabis, D., Rahman, M. M., Wahed, M. A., Islam, M. A. & Habte, D. (1997) Vitamin A megadose during early infancy on serum retinol concentration and acute side effects and residual effects on 6 month follow-up. Nutr. Res. 17: 649-659.
17. Mark, D. A., Baliga, B. S. & Suskind, R. M. (1983) All-trans retinoic acid reverses immune-related hematological changes in the vitamin A deficient rat. Nutr. Rep. Int. 28: 1245-1252.
18. Nauss, K. M. (1986) Influence of vitamin A status on the immune system. In: Vitamin A Deficiency and Its Control (Bauernfeint, C., ed.), pp. 207-243. Academic Press, Orlando, FL.
19. Nauss, K. M., Mark, D. A. & Suskind, R. M. (1979) The effect of vitamin A deficiency on the in vitro cellular immune response in rats. J. Nutr. 109: 1815-1823.
20. Nauss, K. M., Phua, C. C., Ambrogi, L. & Newberne, P. M. (1985) Immunological changes during progressive states of vitamin A deficiency in the rat. J. Nutr. 115:909-918.
21. Olson, J. (1994) Vitamin A, retinoids, and carotenoid. In: Modern Nutrition in Health and Disease (Shils, M. E., Olson, S. A. & Shike, M., eds.), 8th ed., vol. 1, pp. 287-307. Lea & Febiger, Philadelphia, PA.
22. Pasatiempo, A.M.G., Bowman, T. A., Taylor, C. E. & Ross, A. C. (1989) Vitamin A depletion and repletion:effects on antibody response to the capsular polysaccharide of Streptococcus pneumoniae, type III (SSS-III). Am. J. Clin. Nutr. 49: 501-510.
23. Rahman, M. M., Alvarez, J. O., Mahalanabis, D., Wahed, M. A., Islam, M. A., Unicomb, L., Habte, D. & Fuchs, G. J. (1998) Effect of vitamin A administration on response to oral polio vaccination. Nutr. Res 18: 1125-1133.
24. Rahman, M. M., Mahalanabis, D., Alvarez, J. O., Wahed, M. A., Islam, M. A., & Habte, D. (1997) Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 month. Am. J. Clin. Nutr. 65: 144-148.
25. Rahman, M. M., Mahalanabis, D., Alvarez, J. O., Wahed, M. A., Islam, M. A., Habte, D. & Khaled, M. A. (1996) Acute respiratory infections prevent improvement of vitamin A status in young infants supplemented with vitamin A. J. Nutr. 126: 628-633.
26. Robertson, S. E. (1993) Poliomyelitis, Immunological Basis for Immunization, pp. 1-24. World Health Organization, Geneva, Switzerland.
27. Ross, A. C. (1992) Vitamin A status: relationship to immunity and the antibody response. Proc. Soc. Exp. Biol. Med. 200: 303-320.
28. Semba, R. D. (1994) Vitamin A, immunity, and infection. Clin. Infect. Dis. 19: 489-499.
29. Semba, R. D., Muhilal, Scott, A. L., Natadisastra, G., Wirasasmita, S., Mele, L., Ridwan, E., West, K. P., Jr. & Sommer, A. (1992) Depressed immune response to tetanus in children with vitamin A deficiency. J. Nutr. 122: 101-107.
30. Siber, G. R., Thakrar, N., Yancey, B. A., Herzog, L., Tood, C., Cohen, N., Sekura, R. D. & Lowe, C. U. (1991) Safety and immunogenicity of hydrogen peroxide-inactivated pertussis toxoid in 18-month-old children. Vaccine 9: 735-740.
31. Smith, S. M. & Hayes, C. E. (1987) Contrasting impairment of IgM and IgG responses of vitamin A-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 84: 5878-5882.
32. Smith, S. M., Levy, N. S. & Hayes, C. E. (1987) Impaired immunity in vitamin A-deficient mice. J. Nutr. 117: 857-865.
33. Sommer, A., Katz, J. & Tarwotjo, I. (1984) Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am. J. Clin. Nutr. 40: 1090-1095.
34. Sommer, A., Tarwotjo, I., Hussaini, G. & Susanto, D. (1983) Increased mortality in children with mild vitamin A deficiency. Lancet 2: 585-588.
35. Wang, W. & Ballow M. (1993) The effects of retinoic acid on in vitro immunoglobulin synthesis by cord blood and adult peripheral blood mononuclear cells. Cell Immunol. 148: 291-300.
36. Wang, W., Napoli, J. L. & Ballow, M. (1993) The effects of retinol on in vitro immunoglobulin synthesis by cord blood and adult peripheral blood mononuclear cells. Clin. Exp. Immunol. 92: 164-168.
37. WHO/UNICEF/USAID/Helen Keller International/IVACG. (1982) Report of a meeting. Control of Vitamin A Deficiency and Xerophthalmia. Technical Report Series, no. 672. World Health Organization, Geneva, Switzerland.
38. World Health Organization (1989) Expanded program on immunization: progress and evaluation report. WHO (A42/10),Geneva, Switzerland.
39. Zollinger, W. D. & Boslego, J. W. (1981) A general approach to standardization of the solid-phase radioimmunoassay for quantitation of class-specific antibodies. J. Immunol. Methods 46: 129-140.