Vitamin A megadoses during early infancy on serum retinol concentration and acute side effects and residual effects on 6 month follow-up

Nutrition Research

Volumn 17, Issue 4, 1997, Pages 649-659

  Mahalanabis, Dilip ^a   Rahman, Mohammed M ^a   Wahed, Mohammed A ^a   Islam, Mohammed A ^a   Habte, Demissie ^a  

^a INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

Author keywords

bulged fontanelle; vitamin A deficiency; Vitamin A megadoses; vitamin A toxicity; young infants

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS VACCINE; ORAL POLIOMYELITIS VACCINE; RETINOL; RETINOL BINDING PROTEIN; RETINOL PALMITATE;

ANTERIOR FONTANEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNODIFFUSION; INFANT; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINOL DEFICIENCY; SAFETY; VITAMIN BLOOD LEVEL;

EID: 0031054927     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(97)00035-3     Document Type: Article

References (14)

1. Olson JA, Gunning DB, Tilton RA. Liver concentrations of vitamin A and carotenoids, as a function of age and other parameters, of American children who died of various causes. Am J Clin Nutr 1984;39:903-10.
2. Zachman RD. Retinol (vitamin A ) and the neonate: special problems of the human premature infant. Am J Clin Nutr 1989;50:413-24.
3. Shenai JP, Rush MG, Stahlman MT, Chytil F. Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. J Pediatr 1990;116:607-14.
4. Stephensen C, Alvarez J, Hardmeier R, Kohatsu et al. Vitamin A is excreted at high levels in the urine of patients with pneumonia and sepsis. FASEB J 1993;7:A511.
5. Sommer A, Tarwotjo I, Djunaedi E, et al. Impact of vitamin A supplementation on childhood mortality: a randomised controlled community trial. Lancet 1986;1:1169-73.
6. Beaton GH, Martorell R, L'Abbe KA, et al. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. SCN News 1993;(9):17-23.
7. Olson JA. Recommended dietary intakes (RDI) of vitamin A in humans. Am J Clin Nutr 1987;45:704-16.
8. de Francisco A, Chakraborty J, Chowdhury HR, et al. Acute toxicity of vitamin A given with vaccines in infancy. (Short report). Lancet 1993;342:526-7.
9. Gray RH. The integration of demographic and epidemiological approaches to studies of health in developing countries. In: Ruzicka L, Wuasch G, Kane P, eds. Differential mortality: methodological issues and biosocial factors. New York: Clarendon press, 1989.
10. Anonymous. Missed opportunities for immunization in hospitals. Reports from the Expanded Programme on Immunization, Bangladesh. Dhaka: EPI-Bangladesh, 1988.
11. Catignani GL, Bieri JG. Simultaneous determination of retinol and α-tocopherol in serum or plasma by liquid chromatography. Clin Chem 1983;29:708-12.
12. Hathcock JN, Hattan DG, Jenkins MY, McDonald JT, Sundaresan PR, Wilkening VL. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.
13. Gross TP, Milstien JB, Kuritsky JN, Bulging fontanelle after immunization with diphtheria-tetanus-pertussis and diphtheria-tetanus vaccine. J Pediatr 1989;114:423-5.
14. UNICEF. State of the world's children 1993. p. 70.